| A Prospective Study of Intrafamilial Spread in Hepatitis B Viral Infection. |
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Ki Sub Chung, Jong Wie Choi |
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Department of Pediatrics, Yonsei University of Medicine, Seoul, Korea |
| 간염 B의 가족내 전파에 관한 연구 |
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정기섭, 최종위 |
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연세대학교 의과대학 소아과학교실 |
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| Abstract |
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The pediatric liver disease involves primarily viral infection of type A or type B. Presently
the hepatitis incidences are on the rising trend in Korea, especially the type B viral hepatitis.
It is estimated that approximately 4〜5% of the school children are HBsAg chronic
carriers which are posing threat to citizens health status. We examined 264 patients
admitted to Severance hospital at Yonsei medical college as acute viral hepatitis from Jan,
1980 to Feb, 1982 and discovered that 82 patients possesed Hepatitis B markers in. their serum.
The presence of hepatitis B markers and their mode of transmission among the families of
these hepatitis B markers positive patients were investigated.
The results are as follows.
1. Among 264 patients with acute viral hepatitis, 82 patients came down, with hepatitis B
viral infection. Compared with other age groups, the patients age between 7 and 10 years
old had highest incidence rate as 28%. The hepatitis B incidence ratio of male to female was
1.8:1.
2. Among 82 patients with hepatitis B viral infection, HBsAg was found in 59 patients
(72.0%), Anti-HBs in 21 patients(25.6%) and both HBsAg & Anti-HBs in. 2 patients(2.4%).
3) In. intrafamilial study, the positive incidence rate of HB markers among mothers and
fathers were 80.4% and 79.5% respectively, whose incidence rates were much higher than,
any other family members.
4. When both parents have HB markers, their children had much higher HB markers
positive rate of 72% comparing with 41.7% in children of both parents without HB markers.
5. In HB markers positive rate of mothers by age distribution of patients, mothers of
patients with younger age group had much higher positive rate than, those of patients with,
older age group. Especially, mothers of patients under 1 year old age had HB markers
positive rate of 88%. This reflected the important role of mothers in vertical transmission
or close contact with their children, in the development of hepatitis B viral infection.
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| Key Words:
Intrafamilial Spread in Hepatitis B Viral infection |
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