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- Review Article
- Neurology
- Recent update on reading disability (dyslexia) focused on neurobiology
- Sung Koo Kim
- Clin Exp Pediatr. 2021;64(10):497-503. Published online March 2, 2021
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·Neurobiological studies using functional brain imaging have uncovered the reading pathways, brain regions involved in reading, and neurobiological abnormalities of dyslexia.
·An accurate diagnosis and timely specialized intervention are important in children with dyslexia. When national infant development screening tests have been conducted as in Korea, if a language developmental delay and early predictors of dyslexia are detected, the progression to dyslexia should be carefully observed and early intervention provided.
- Original article
- Infection
- The global prevalence of Toxocara spp. in pediatrics: a systematic review and meta-analysis
- Behnam Abedi, Mehran Akbari, Sahar KhodaShenas, Alireza Tabibzadeh, Ali Abedi, Reza Ghasemikhah, Marzieh Soheili, Shnoo Bayazidi, Yousef Moradi
- Clin Exp Pediatr. 2021;64(11):575-581. Published online February 5, 2021
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Is the global prevalence of toxocariasis high among children? The prevalence of toxocariasis is high in pediatric patients. Asian children are more susceptible to the disease than other children. Its virulence varies among different socioeconomic classes in various countries. Hand washing after soil contact, routine pet deworming, and appropriate disposal of pet feces in households with Asian pediatrics are needed to prevent toxocariasis.
- Case Report
- An adverse event following 2009 H1N1 influenza vaccination: a case of acute disseminated encephalomyelitis
- Sang Teak Lee, Young June Choe, Won Jin Moon, Jin Woo Choi, Ran Lee
- Clin Exp Pediatr. 2011;54(10):422-424. Published online October 31, 2011
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Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system that typically follows an infection or vaccination and has a favorable long-term prognosis. We describe the first reported case of ADEM after vaccination against novel influenza A (H1N1). A previously healthy 34-month-old boy who developed ADEM presented with a seizure and left-sided weakness 5 days after...
- Original Article
- Hu.4-1BB-Fc fusion protein inhibits allergic inflammation and airway hyperresponsiveness in a murine model of asthma
- Byoung-Ju Kim, Ji-Won Kwon, Ju-Hee Seo, Won-Ah Choi, Young-Jun Kim, Mi-Jin Kang, Jinho Yu, Soo-Jong Hong
- Clin Exp Pediatr. 2011;54(9):373-379. Published online September 30, 2011
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Purpose 4-1BB (CD 137) is a costimulatory molecule expressed on activated T-cells. Repression by 4-1BB is thought to attenuate Th2-mediated allergic reactions. The aim of this study was to investigate the effect of 4-1BB on allergic airway inflammation in a murine asthma model.
Methods BALB/c mice were sensitized to and challenged with ovalbumin (OVA). Hu.4-1BB-Fc was administered 1 day before the first OVA...
- Case Report
- A case of thanatophoric dysplasia type I with an R248C mutation in the
FGFR3 gene - Eun Jung Noe, Han Wook Yoo, Kwang Nam Kim, So Yeon Lee
- Clin Exp Pediatr. 2010;53(12):1022-1025. Published online December 31, 2010
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Thanatophoric dysplasia (TD) is a short-limb neonatal dwarfism syndrome that is usually lethal in the perinatal period. It is characterized by shortening of the limbs, severely small thorax, large head with a prominent forehead, macrocephaly, curved femur, and flattened vertebral bodies. These malformations result from the mutation in fibroblast growth factor receptor 3 (FGFR-3) gene which is located on the...
- A case of Hyper-IgE syndrome with a mutation of the STAT3 gene
- Ji-man Kang, Jungmun Suh, Jihyun Kim, Hee-Jin Kim, Yae-jean Kim, Hun Seok Lee, Young Kee Shin, Kangmo Ahn, Sang-Il Lee
- Clin Exp Pediatr. 2010;53(4):592-597. Published online April 15, 2010
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Hyperimmunoglobulin E syndrome (HIES) is a rare immunodeficiency disease which is characterized by high serum IgE levels, eczema, and recurrent infections. Herein we present the case of a patient with HIES associated with STAT3 gene (stat3) mutation. A 16 year-old girl was admitted to our hospital due to hemoptysis caused by pneumonia with bronchiectasis. She had a history of recurrent... -
- Original Article
- Respiratory syncytial virus infection cases in congenital heart disease patients
- Woo Sup Shim, Jae Yeong Lee, Jin Yong Song, Soo Jin Kim, Sung Hye Kim, So Ick Jang, Eun Yong Choi
- Clin Exp Pediatr. 2010;53(3):380-391. Published online March 15, 2010
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Purpose : Respiratory syncytial virus (RSV) is one of the main pathogens causing lower respiratory infections (LRI) in young children, usually of limited severity. However, in congenital heart disease (CHD) patients, one of the high-risk groups for RSV infection, RSV can cause serious illnesses and fatal results. To elucidate the effects of RSV infection in CHD patients, we observed RSV... -
- Review Article
- Pediatric dual-energy X-ray absorptiometry: interpretation and clinical and research application
- Jung Sub Lim
- Clin Exp Pediatr. 2010;53(3):286-293. Published online March 15, 2010
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Peak bone mass is established predominately during childhood and adolescence. It is an important determinant of future resistance to osteoporosis and fractures to gain bone mass during growth. The issue of low bone density in children and adolescents has recently attracted much attention and the use of pediatric dual-energy X-ray absorptiometry (DXA) is increasing. The process of interpretation of pediatric... -
- Original Article
- Serum methotrexate level is inversely related to the outcome of osteosarcoma patients
- Jun Ah Lee, Min Suk Kim, Jin Kyung Lee, Dong Ho Kim, Young Joon Hong, Won Seok Song, Wan Hyeong Cho, Soo-Yong Lee, Jung Sub Lim, Kyung Duk Park, Dae-Geun Jeon
- Clin Exp Pediatr. 2009;52(5):581-587. Published online May 15, 2009
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Purpose : To evaluate the correlation between serum methotrexate (MTX) peak levels and clinical outcome of osteosarcoma, as well as to determine the correlation of these levels with the histologic response and event-free survival (EFS). Methods : To maintain the homogeneity of the study population, we selected 52 patients with localized extremity osteosarcoma who had received two cycles of neoadjuvant... -
- Erratum
- A new strategy for transcatheter closure of patent ductus arteriosus with recent-generation devices
- Sang Yee Kim, Soo Hyun Lee, Nam Kyun Kim, Jae Young Choi, Jun Hee Sul
- Accepted January 1, 1970
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Purpose : The aim of this study was to assess the efficacy and safety of recent-generation patent ductus arteriosus (PDA) closure devices applied by a new selection strategy according to the characteristics of each PDA. Methods : From February 2003 to January 2006, 138 patients underwent transcatheter closure of PDA (study group). According to the size and morphology of each... -
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- Case Report
- A case of mosaic ring chromosome 13 syndrome
- Soo Young Kim, Soo Min O, Mi Jeong Kim, Eun Song Song, Young Ok Kim, Young Youn Choi, Young Jong Woo, Tai Ju Hwang
- Clin Exp Pediatr. 2009;52(2):242-246. Published online February 15, 2009
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The clinical features of ring chromosome 13 include mental and growth retardation, CNS anomalies, facial dysmorphism, cardiac defects, genital malformations, limb anomalies, skeletal deformities and anal malformations. Although many cases of ring chromosome 13 have been reported worldwide, only 6 cases have been reported in Korea, and the latter cases were not mosaic but pure ring chromosome 13. Here we... -
- Hand-Foot syndrome induced by sorafenib, a multitargeted tyrosine kinase inhibitor, in a patient with advanced renal cell carcinoma
- Seung Hyun Lee, Sung Hun Noh, Sun Young Kim, Kyu Yun Jang, Pyoung Han Hwang
- Clin Exp Pediatr. 2009;52(1):119-123. Published online January 15, 2009
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Renal cell carcinoma (RCC) arising from epithelial cells of the renal tubules is a highly aggressive and malignant tumor in all ages; however, it rarely occurs in children. the standard treatment for RCC is radical nephrectomy with lymph node dissection when the tumor is localized and can be completely resected. Adjuvant chemotherapy, radiotherapy, and immunotherapy are used for pediatric patients... -
- Original Article
- Comparative study of typical and atypical benign epilepsy with centrotemporal spikes (Rolandic epilepsy)
- Junhyuk Song, Kyuha Lee, Sajun Chung
- Clin Exp Pediatr. 2008;51(10):1085-1089. Published online October 15, 2008
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Purpose : This study aims to examine and compare the features of rolandic epilepsy. Methods : Of 158 patients selected retrospectively, 116 had typical (group A) and 42 had atypical (group B) rolandic epilepsy, as defined by Worrall's criteria. Results : The age at onset of the seizures in group A was 8.6¡¾2.0 y and 6.2¡¾1.7 y in group B... -
- Review Article
- Once daily dosing of aminoglycoside in children
- Seon Hee Shin
- Clin Exp Pediatr. 2008;51(10):1038-1041. Published online October 15, 2008
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Aminoglycosides are frequently used antibiotics in children. The multiple daily dosing (MDD) in infants and children is twice or three times daily depending on age. Recent studies in adults have shown that once daily dosing (ODD) maximizes the bactericidal activity and might minimize the toxicity of antibiotics. So, I reviewed many studies about efficacy, toxicity and cost effectiveness of ODD... -
- Erratum
- \Improving women's and children's health in DPRK\" project funded by the Republic of Korea"
- Young-Jeon Shin
- Accepted January 1, 1970
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The economic recession of North Korea has been prolonged, the need for humanitarian assistance for the women and children of DPRK has been raised. In March 2006, South Korean government signed MOU with World Health Organization (WHO) to financially support "Improving Women's and Children's Health in DPRK (IWCH)" project. The assistance projects through UNICEF and the non-government organizations of South... -
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- Original Article
- The utility of ambulatory blood pressure monitoring in obese children
- Myung Jin Kim, Jin Young Song
- Clin Exp Pediatr. 2008;51(6):604-609. Published online June 15, 2008
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Purpose : Obesity in children and adolescence is highly correlated with adult obesity, which can provoke hypertension. Therefore, it is important to evaluate the blood pressure of obese children regularly. In this study, the results of ambulatory blood pressure monitoring (ABPM) in obese children and adolescents were evaluated. Methods : ABPM was conducted for selected patients who visited Handong University... -
- Case Report
- Cerebro-oculo-facio-skeletal syndrome : A case report
- So Hee Lee, Seong Jin Hong, Jung Hwa Lee, Soo Yun Oh, Sun Heum Kim, Duk Hwan Kho, Kyo Sun Kim
- Clin Exp Pediatr. 2008;51(4):435-438. Published online April 15, 2008
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The Cerebro-oculo-facio-skeletal (COFS) syndrome is a rare autosomal recessive disorder characterized by multiple abnormalities that involve the brain, face, eyes, and extremities. COFS syndrome is regarded as a degenerative disorder of the brain and spinal cord caused by a mutation of the DNA repair genes. We report on an 8-month-old girl with COFS syndrome who exhibited growth and developmental delay,... -
- Original Article
- Efficacy and safety of electrolytes-free polyethylene glycol (PEG) 4000 for disimpaction in children with chronic functional constipation
- Jeong Hee Lee, Ran Lee, Sun Hwan Bae
- Clin Exp Pediatr. 2008;51(4):391-395. Published online April 15, 2008
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Purpose : This study was performed evaluate optimal dose for disimpaction, efficacy and safety of PEG 4000 in children with chronic functional constipation. Methods : Eighty six children with chronic functional constipation were enrolled in this prospective study at Konkuk university hospital March, 2003 through August, 2006. Success in disimpaction with PEG 4000 was defined as meeting at least two out... -
- Glutathione S-transferase polymorphism of neonatal hyperbilirubinemia in Korean neonates
- Chang Seok Kang, Seung Su Hong, Ji Sook Kim, Eun Ryoung Kim
- Clin Exp Pediatr. 2008;51(3):262-266. Published online March 15, 2008
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Purpose : Glutathione S-transferase (GST) is a polymorphic supergene family of detoxification enzymes that are involved in the metabolism of numerous diseases. Several allelic variants of GSTs show impaired enzyme activity and are suspected to increase the susceptibility to diseases. Bilirubin is bound efficiently by GST members. The most commonly expressed gene in the liver is GSTM1, and GSTT1 is... -
- Case Report
- A case of delayed hemorrhage of a subcapsular liver hematoma in a neonate
- Soo Kyoung Moon, Tae Suk Lee, Hye Sun Yoon
- Clin Exp Pediatr. 2008;51(1):89-92. Published online January 15, 2008
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A subcapsular liver hematoma (SLH) is a relatively common lesion in fetuses and neonates. Although an SLH ruptures rarely, it may be life threatening. We report on a term neonate with a delayed rupture of an SLH that occurred on day 7 of life. The infant had been resuscitated with intubation, positive pressure ventilation, and chest compression at birth because... -
- Original Article
- The ages and stages questionnaire: screening for developmental delay in the setting of a pediatric outpatient clinic
- Eun Young Kim, In Kyung Sung
- Clin Exp Pediatr. 2007;50(11):1061-1066. Published online November 15, 2007
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Purpose : Early identification of developmental disabilities allows intervention at the earliest possible point to improve the developmental potential. The Ages and Stages Questionnaire (ASQ), a parent- completed questionnaire, can be used as a substitute for formal screening tests. The purpose of this study was to evaluate the validity of the Korean version of the ASQ (K-ASQ) as a screening... -
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- Clinical significance of serum vascular endothelial growth factor in Kawasaki disease
- Ho Seok Lee, Sin Weon Yun, Young Soo Jung, Soo Ahn Chae, In Seok Lim, Dong Keun Lee, Eung Sang Choi, Byung Hoon Yoo, Mi Kyung Lee
- Clin Exp Pediatr. 2007;50(10):995-1004. Published online October 15, 2007
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Purpose : Kawasaki disease is a systemic vasculitis, leading cause of pediatric acquired heart disease. Vascular endothelial growth factor (VEGF) has functions as vascular permeability factor, plays an important role in coronary artery lesion (CAL). We studied the clinical significance of serum VEGF in Kawasaki disease. Methods : Kawasaki group was 49 patients, and control group was 15 patients. Diagnosis followed... -
- Case Report
- A familial case report of paroxysmal kinesigenic dyskinesia in three brothers
- Oh Dae Kwon, Sung Jin Hwang, Jun Hwa Lee, Ji Eun Kim, Kyung Jib Kim, Eul Ju Seo
- Clin Exp Pediatr. 2007;50(7):694-697. Published online July 15, 2007
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Paroxysmal kinesigenic dyskinesia (PKD), previously referred to as movement-provoked seizures, is a rare neurological condition that is characterized by short duration dystonic or choreoathetotic movements precipitated by sudden movement, a change in position or hyperventilation. It can be difficult to distinguish this syndrome from seizures. We reported on three brothers in one family all of whom developed abnormal involuntary dystonic... -
- A case of childhood relapsing/remitting multiple sclerosis and interferon β-1b treatment in a Korean patient
- Hyun Seok Kim, Won Deok Lee, Jun Hwa Lee, Kyung Lae Cho
- Clin Exp Pediatr. 2007;50(6):580-584. Published online June 15, 2007
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Multiple sclerosis (MS) is a demyelinating disorder that affects discrete areas of the CNS, including the optic nerves, in a quite variable relapsing-remitting fashion over a prolonged period of time. Although MS is usually considered to be a disease that affects peoples in early to middle adulthood, children do develop multiple sclerosis. The frequency of MS onset before the age... -
- Identification of a de novo mutation (H435Y) in the THRB gene in a Korean patient with resistance to thyroid hormone
- Jin Young Shin, Chang-Seok Ki, Jin Kyung Kim
- Clin Exp Pediatr. 2007;50(6):576-579. Published online June 15, 2007
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The syndrome of resistance to thyroid hormone (RTH) is characterized by reduced tissue sensitivity to thyroid hormone (TH). In the majority of subjects, RTH is caused by mutations in the thyroid hormone receptor beta (TRβ) gene, located on the chromosome locus 3p24.3. RTH is inherited in an autosomal dominant manner. The clinical presentation of RTH is variable, but common features... -
- Original Article
- Analysis of anthropometric data for premature infants of 26 to 35 weeks of gestation; comparison with the data of 1960's
- Ji A Aum, Hee Jin Jung, Jae Won Huh, Sang Hee Son
- Clin Exp Pediatr. 2007;50(6):543-548. Published online June 15, 2007
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Purpose : The anthropometric data of newborns published by Lubchenco et al in the 1960's have been most commonly used in Korea as a standard of newborn growth. We hypothesized that Lubchenco's data have limitations for Korean premature infants born in the 2000's. We analyzed and compared the data of birth weight, length, and head circumference. Methods : The medical records... -
- Case Report
- A case of idiopathic renal hypouricemia
- Moon Hee Han, Sang Uk Park, Deok-Soo Kim, Jae Won Shim, Jung Yeon Shim, Hye Lym Jung, Moon Soo Park
- Clin Exp Pediatr. 2007;50(5):489-492. Published online May 15, 2007
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Idiopathic renal hypouricemia is a disorder characterized by impaired urate handling in the renal tubules. This disease usually produces no symptoms, but hematuria, uric acid nephrolithiasis or acute renal failure may develop. A defect in the SLC22A12 gene, which encodes the human urate transporter, is the known major cause of this disorder. We describe a 10-month-old boy with idiopathic renal... -
- Original Article
- The relation between angiotensin converting enzyme (ACE) gene polymorphism and neonatal hyperbilirubinemia in Korea
- Mi Yeoun Kim, Jae Myoung Lee, Ji Sook Kim, Eun Ryoung Kim, Hee Jae Lee, Seo Hyun Yoon, Joo Ho Chung
- Clin Exp Pediatr. 2007;50(1):28-32. Published online January 15, 2007
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Purpose : Human angiotensin converting enzyme (ACE) gene shows an insertion/deletion polymorphism in 16 intron, and three genotypes are determined by whether a 287 bp fragment of the DNA is present or not; II, ID and DD genotype. DD genotype has been suggested as a risk factor of chronic nephrotic disease such as IgA nephropathy and diabetic nephropathy, various cardiovascular... -
- Case Report
- Acute hemorrhagic edema in an infant mimicking Henoch-Sch nlein purpura: a case study
- Hyang Mo Lee, Eun Young Kang, Han Uk Kim, Pyoung Han Hwang
- Clin Exp Pediatr. 2006;49(12):1354-1357. Published online December 15, 2006
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Acute hemorrhagic edema of infancy (AHEI) is an uncommon form of cutaneous leukocytoclastic vasculitis that occurs in infants and children younger than 2 years. AHEI is characterized clinically by marked peripheral edema and fever as well as large palpable purpuric and ecchymotic skin lesions in a target-like pattern, mainly on the face, ears and extremities, similar to the skin findings... -
- Original Article
- Adolescent obesity and the elevation of aminotransferase levels
- Su Yeon Kim, Ho Jun Lee, Tae Su Park, Soo Geun Kim, Hye Jung Shin
- Clin Exp Pediatr. 2006;49(10):1037-1041. Published online October 15, 2006
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Purpose : The prevalence of obesity and nonalcoholic steatohepatitis(NASH) was increased in adolescents. This study was performed to observe the prevalence of elevated aminotransferase levels in adolescents and to assess the correlations between aminotransferase levels and obesity related parameters(body mass index, waist circumference, hip circumference, waist to hip ratio and insulin level). Methods : We obtained weight, height, waist circumference and... -
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8.02023CiteScore94th percentilePowered by
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