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Original Article
Pulmonology
Oligohydramnios affects pulmonary functional/structural abnormalities in school-aged children with bronchopulmonary dysplasia
Jeong Eun Shin, Soon Min Lee, Mi-Jung Lee, Jungho Han, Joohee Lim, Haerin Jang, Ho Seon Eun, Min Soo Park, Soo Yeon Kim, Myung Hyun Sohn, Ji Ye Jung, Kyung Won Kim
Clin Exp Pediatr. 2024;67(5):257-266.   Published online April 16, 2024
Question: Is bronchopulmonary dysplasia (BPD) associated with functional/structural abnormalities later in life?
Finding: School-aged children with severe BPD had abnormalities on pulmonary function tests and lung computed tomography despite no subjective respiratory symptoms; however, only prenatal oligohydramnios and prolonged ventilator use were associated with abnormal lung function.
Meaning: Long-term monitoring of preterm infants’ lung health is essential, especially for those with prenatal oligohydramnios or prolonged ventilator use.
Review Article
Endocrinology
Applications of genomic research in pediatric endocrine diseases
Ja Hye Kim, Jin-Ho Choi
Clin Exp Pediatr. 2023;66(12):520-530.   Published online June 14, 2023
· Recent advances in molecular genetics have improved our understanding of pediatric endocrine disorders and are now used in mainstream medical practice.
· Genome-wide association studies can increase our understanding of the biological mechanisms of disease and inform new therapeutic options.
· The identification of founder mutations leads to the efficient localization of the genes underlying Mendelian disorders.
· Next-generation sequencing technologies benefit clinical practice and research of pediatric endocrinology.
Original Article
Neurobehavior
Association between assisted reproductive technology and autism spectrum disorders in Iran: a case-control study
Ensiyeh Jenabi, Mahdieh Seyedi, Ronak Hamzehei, Saeid Bashirian, Mohammad Rezaei, Katayoon Razjouyan, Salman Khazaei
Clin Exp Pediatr. 2020;63(9):368-372.   Published online March 27, 2020
Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by impairments in social interaction and verbal and nonverbal communication.
Purpose: Determine the association between use of assisted reproduction technology (ART) and the risk of ASD among children. Methods: This case-control study included 300 participants (100 cases, 200 controls). The control group included women with a child aged 2–10 years without ASD,...
Case Report
Two cases of Smith-Magenis syndrome
Seong Kwan Jung, Kyu Hee Park, Hae Kyung Shin, So Hee Eun, Baik-Lin Eun, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Sook Young Bae
Clin Exp Pediatr. 2009;52(6):701-704.   Published online June 15, 2009
SmithMagenis syndrome (SMS) is a rare disorder with multiple congenital anomalies caused by a heterozygous interstitial deletion involving chromosome 17p11.2, where the retinoic acid-induced 1 (RAI1) gene is located, or by a mutation of RAI1. Approximately 90% of the patients with SMS have a detectable 17p11.2 microdeletion on fluorescence in-situ hybridization (FISH). SMS is characterized by mental retardation, distinctive behavioral...
Original Article
A clinical study of congenital chylothorax and octreotide therapy
Ung Geon Oh, Kyoung Eun Choi, Kyung Ah Kim, Sun Young Ko, Yeon Kyung Lee, Son Moon Shin
Clin Exp Pediatr. 2008;51(11):1172-1178.   Published online November 15, 2008
Purpose : Congenital chylothorax is an accumulation of lymphatic fluid within the pleural space. It is a common cause of unidentified hydrops fetalis. We examined the perinatal history, clinical manifestation, diagnosis, treatment, and outcome in 6 newborns diagnosed to have congenital chylothorax with hydrops fetalis. We also studied the effect of octreotide therapy for congenital chylothorax in relation to conservative...
Clinical manifestations patterns of allergic disease in Korean children under the age of 6 : multi-center study
Dong Il Kim, Hyeon Jong Yang, Young Mean Park, Yeong Ho Rha, Ji Tai Choung, Bok Yang Pyun
Clin Exp Pediatr. 2008;51(6):640-645.   Published online June 15, 2008
Purpose : It is widely known that allergic diseases progress through an allergic march. However, there have not been any recent reports in Korea on how the diseases progress. Methods : Parents who visited one of the Pediatric Allergy Clinics of four university hospitals in Seoul with a child under the age of 6 years during the period from May...
An epidemiologic study on the seropositive rate of hepatitis A virus among a selected group of children and adults in Busan
Young Ok Kwon, Im Jeong Choi, Jin Wha Jung, Ji Hyun Park
Clin Exp Pediatr. 2007;50(3):262-267.   Published online March 15, 2007
Purpose : The prevalence of hepatitis A virus (HAV) in a certain community reflects that community's living standards and hygienic conditions. And the pattern of HAV infection differs over time and geography. Recently, a shift in prevalence has been observed in cases from chilhood to adulthood. We studied the HAV antibody prevalence in the general population in Busan. Methods : From...
Surfactant Therapy for Neonatal Respiratory Distress Syndrome : Experience in Korea Over 15 Years
Chong-Woo Bae, Young-Min Kim
Clin Exp Pediatr. 2004;47(9):940-948.   Published online September 15, 2004
Purpose : Surfactant replacement therapy in neonates with respiratory distress syndrome(RDS) has been used in Korea since 1990. We undertook a collective study of trials from multi-hospitals to evaluate results of neonates with RDS who were treated with surfactant during the past 15 years in Korea(Period I, P-I, 1990-91; Period II, P-II, 1996; Period-III, P-III; 2002). Methods : There were 60...
Change of Cerebral Blood Flow during Tilt Tests in Children with Vasovagal Syncope
Su Jung Kim, Hye Won Yom, Young Mi Hong, Jung Hyen Yoo, Sook Hee Lee, Chong Hee Kim
Clin Exp Pediatr. 2003;46(10):983-988.   Published online October 15, 2003
Purpose : Syncope appears to be common. However, the mechanism of syncope is not clear. Increased vagal activity and withdrawal of sympathetic stimulation cause hypotension, bradycardia and finally loss of consciousness. The purpose of this study was to evaluate changes of cerebral blood flow velocity, blood pressure, and heart rate during tilt test in children with vasovagal syncope. Methods : Sixty...
Case Report
A Case of Rhizomelic Chondrodysplasia Punctata Type I
Dal Hyun Kim, Young Se Kwon, Yong Hoon Jun, Young Jin Hong, Byoung Kwan Son, Hye Ran Yoon
Clin Exp Pediatr. 2002;45(12):1585-1590.   Published online December 15, 2002
Rhizomelic chondrodysplasia punctata(RCDP) is a rare autosomal recessive disorder clinically characterized by symmetrical shortening of the proximal limbs, contractures of joints, a typical dysmorphic face, cataracts, and itchyosis. Patients with RCDP can be subdivided into three subgroups based on biochemical analysis and complementation studies. RCDP type I results from mutations in the PEX7 gene encoding the peroxisomal targeting signal type...
Two Cases of Gitelman's Syndrome Diagnosed by Renal Clearance Study
Tae Hwa Kim, Seung Jun Kim, Yu Kyung Seo, Jung-Yeon Shim, Hye Lim Jung, Moon Soo Park, Dong Hyuk Kum
Clin Exp Pediatr. 2002;45(3):413-417.   Published online March 15, 2002
Gitelman's syndrome is an autosomal recessive disorder characterized by hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria that has recently been reported to be linked to thiazide-sensitive Na-Cl cotransporter gene mutation. In this study, we performed renal clearance studies to differentiate Gitelman's from Bartter's syndrome and to confirm the diagnosis in two patients clinically diagnosed with Gitelman's syndrome. Each patient was hydrated...
Original Article
A Prospective Epidemiological Study on Birth Defects : A Community Based Pilot Study
Hyon Ju Kim, Yeon Kyeoung Kim, Dae Kyun Koh, Jong Hyun Kim, Bo Won Choi
Clin Exp Pediatr. 2000;43(6):738-745.   Published online June 15, 2000
Purpose : This prospective pilot study is a part of the Korean NIH’s effort to characterize congenital anomalies and genetic disorders in Korea and to establish a National Genetic Database. Methods : This population-based study was conducted at all hospitals that deliver in the province of Suwon; a total of 39 hospitals from May 1, 1997 to April 30, 1999 for...
A Study on the Clinical Significance of Periodic Lateralized Epileptiform Discharges and Relation to Brain Imaging Study in Children
Jong Hwa Lee, Eun Young Park, Nam Su Kim, In Joon Seol
Clin Exp Pediatr. 2000;43(3):380-385.   Published online March 15, 2000
Purpose : Periodic lateralized epileptiform discharges(PLEDs), initially described by Chatrian et al in 1964, are an EEG phenomenon characterized by lateralized or focal spike-and-wave complexes with moderate to high voltage which occur in a periodic or semiperiodic pattern. This study was performed to assess the clinical significance of PLEDs and its relation to an imaging study of the brain. Methods :...
A Nationwide Clinical Study of Acute Respiratory Distress Syndrome in Children
Soo Jung Choi, Do Suck Jeong, Jae Won Oh, Ha Baik Lee, Im Ju Kang, Kwang Woo Kim, Kyu Earn Kim, Ki Bok Kim, Young Ho Rah, Kang Seo Park, Byong Kwan Son, Ki Young Lee, Sang Il Lee, Ji Tai Choung, Young Mi Hong
Clin Exp Pediatr. 1999;42(1):23-31.   Published online January 15, 1999
Purpose : Acute respiratory distress syndrome(ARDS) is the final course of acute lung injury. It results from various etiological origins and pathophysiologic mechanisms, and has a mortality rate of approximately 60-70%. Although the confirmative incidence of ARDS in children is yet unknown, the increasing incidence of ARDS has been reported in Korea. In the present study, we report ARDS diagnosed...
Clinical Study on Insulin Dependent Diabetes mellitus
Seog Beom Cho, Kwang Rae Lee, Chang Beom Shin, Oh Kyung Lee, Chong Duk Kim, Oh Kyung Lee
Clin Exp Pediatr. 1995;38(6):827-834.   Published online June 15, 1995
Purpose : Insulin dependet diabetes mellitus(IDDM) is a rare disease in children, but it will progress rapidly and falls into a diabetic ketoacidosis or coma. Unfortunately, the characteristics and prevalence rate of children with IDDM are not well known in Korea. With a view to recognizing its importance, we studied clinical course of IDDM patients in Chonbuk province, Korea. Methods : From...
Immunohistochemical Studies on Neuroendocrine Markers in Malignant Neuronal Tumors (Neuroblastoma and Ganglioneuroblastoma) in Children
Woo Yeong Chung, Sun Kyung Lee
Clin Exp Pediatr. 1992;35(10):1377-1388.   Published online October 15, 1992
The authors studied 24 cases of malignant neuronal tumors, 14 neuroblastomas and 10 ganglioneuroblastomas, immunohistochemically, using antibodies to neuroendocrine markers including neuron specific enolase (NSE), somatostatin, chromogranin, β-endorphin, and adrenocorticotrophic hormone (ACTH). The tissue specimens were obtained by biopsy or autopsy at Pusan National University Hopital and Pusan Paik Hospital from 1980 to 1989. The positive reactivity of markers in...
A Clinicopathological Study on Renal Biopsies in Children
Hun Choi, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 1992;35(6):744-752.   Published online June 15, 1992
A clinical and histopathologic study was made oin 50 cases of renal biopies in children who admitted to chon buk national university hospital from December 1987 to July 1990. The result were as follows : 1) Among 50 cases, 35 cases were male and 15 cases female. The sex ratio of male to female was 2.3 : 1. The age distribution was...
An Epidemiological Study of Bronchial Asthma in Children Who Visited the Emergency Room.
Ju Kwan park, En Jung Kim, Bok Yang Pyun, Sang Jhoo Lee
Clin Exp Pediatr. 1989;32(2):215-222.   Published online February 28, 1989
Presently, an increasing incidence of Bronchial asthma in children is of concern to medical professionals. Worldwide data from surveys indicate a wide range for the prevalence of childhood asthma, it has been estimated that 5-10% of the young population. An epidemiological approach was used to test the prevalence of bronchial asthma out of all pediatric cases referred to the emergency room. 248 cases were selected...
A Epidemiologic Study of Malignant Tumors of Children in Chonnam Area.
Myong Hee Kook, Hys Ran Min, Tai Ju Hwang
Clin Exp Pediatr. 1988;31(1):78-85.   Published online January 31, 1988
A Total 655 cases of malignant tumors in childhood under 15 years of age who admitted to general hospitals in Chonnam area during the 10-year period from January 1976 to December 1985 were analysed. The frequency of malignant tumors among total pediatric inpatients was 2.64% (1.48〜4.52%) with tendency to increse year after year. In 1980, the number of population under 15 years of age...
A Comparative study of Sulbactam/Ampicillin vs Ampicillin/Amikacin in infections of the Pediatric Age Group.
Keun Soo Lee, Ha Baik Lee, Seon Ock Khang, Jung Hee Lee, Tai Yeal Choi, Choon Won Kim
Clin Exp Pediatr. 1986;29(1):1-17.   Published online January 31, 1986
Sulbactam has been shown to be an irreversible inhibitor of bacterial beta.lactamase. The spectrum of Ampicillin is extended hen it is used in combination with Sulbactam to cover Ampicillin resistant organisms. The safety and efficacy of Sulbactamj Ampicillin vs. Ampicillin/Amikacin are compared in the treatment of various disease in pediatric age group Patients are assigned randomly to receive either Sulbactam/...
Clinical Studies on 10 Cases of Rhabdomyosarcoma in Children.
Wan Soeb Kim, Myung Ho Cho, Young Suk Jang, Myung Ho Lee
Clin Exp Pediatr. 1985;28(11):1112-1117.   Published online November 30, 1985
Clinical records of 10 children under 15 years of age with rhabdomyosarcoma confirmed histopathologically were retrospectively during last 8 years from 1973 through 1981 at Presbyterian Medical Center in Jeon-ju. Age range was from 8 months to 12 years of age, and there was no difference in sexes.The most frequent primary site of rhabdomyosarcoma was head and neck area (5 cases...
Skeletal age of korean adolescence.
Chull Sohn, Tae Ju Hwang, Jae Sook Ma, Young Youn Choi
Clin Exp Pediatr. 1985;28(2):111-115.   Published online February 28, 1985
Mean, standard deviation, range and the 10〜 90 percentiles of skeletal maturity scores by the method of Tanner et al in Korean 13- to 17-year-old adolescence were tabled and figured.
A Clinical Study of Intussusception in Infancy and Childhood.
Geom Huyn Jang, Yong Hae Lee, Jun Taek Park, Chang Hee Choi
Clin Exp Pediatr. 1984;27(5):447-456.   Published online May 31, 1984
Intussusception is the condition of invagination of one part of intestinal loop into the continuous distal segment. During infancy and early childhood, intussusception is the most common cause of acquired intestinal obstruction, and it is required emergency treatment. The authors observed 163 cases of intussusception who admitted to Seoul Adventist Hospital from March 1977 to August 1983, and the following results...
Clinical Studies of Convulsive Diseases in Children.
Kyung Ho Kim, Young Kyoung Park, Ki Bok Kim
Clin Exp Pediatr. 1984;27(2):156-163.   Published online February 28, 1984
The authors reviewed 371 pediatric convulsive patients admitted to the Department of Pediatrics, Kwangju Christian Hospital during the 3-year-period from Oct. 1st, 1979 through Sep. 30th, 1982. There were 227 boys and 144 girls. The following observations are made: 1)The most common cause of convulsions in children was encephalitis (20.0%), followed by menigitis(18.3%), febrile convulsion(18.1%), and idiopathic epilepsy (12.4%). 2)Convulsions were...
Clinicao-Pathologic Study on Hyaline Membrane Disease.
Jung Woo Suk, Je G Chi
Clin Exp Pediatr. 1983;26(6):534-544.   Published online June 30, 1983
A total of 27 cases of hyaline membrane disease (idiopathic respiratory distress syndrome was studied clinically, and postmortem findings were reviewed on 14 cases that were available：for autopsy. These 27 cases were obtained during a period of 19 years from January, 1961 to December,1979, at National Medical Center, Seoul. Following results were obtained. 1. The overall incidence of hyaline membrane disease (HMD) among...
Clinical Studies of Purulent Meningitis in Infant and Children.
Sung Ho Chang, Young Gun Kim, Beak Keun Lim, Jong Soo Kim
Clin Exp Pediatr. 1983;26(4):304-314.   Published online April 30, 1983
A clinical study of bacterial meningitis in. 126 cases occurred in the age under 15 year admitted to the department of Pediatrics at Wonju Christsan Hospital, Yonsei University was made from Jan. 1, 1972 to Dec. 31, 1981. The results are as follows. 1) Among the 126 cases. 83 cases (65.9%) were male and 43 cases (34.1%) were female The sex...
Clinical Observation for Prematurity and Low Birth Weight Infant.
Kyung Nam Kim, Jong Wan Kim, Kyoo Hong Cho, Young Heon Kwak
Clin Exp Pediatr. 1982;25(12):1197-1202.   Published online December 31, 1982
Infants who are delivered prior to the term are subject to various disorders which complicate their neonatal course. Neonatal mortality rises progressively with increasing degrees of prematurity. We attempted to know the incidence of birth rate and mortality rate for prematurity and low birth weight infants who were delivered at Our Lady of Mercy Hospital, Catholic Medical College located in Bupyung Dong, Incheon during the...
Clinical Study of Juvenile Diabetes Mellitus.
Keun chull Choi, Seok ku Kim, Chul Lee, Myung ho Lee
Clin Exp Pediatr. 1982;25(5):489-497.   Published online May 31, 1982
We have observed 9 cases of juvenile diabetes mellitus who were admitted to Pediatrics Department of Presbyterian Medical Center in Jeon-ju, during period of 7 years and 2 months from Jan, 1974 to Mar, 1981. The following results were obtained. 1) Incidence of juvenile diabetes mellitus was 0.088% of all patients who were admitted to Pediatric Department ward during period...
Epidemilogical Study of Nares and Umbilicus of Normal Fullterm Newborns in the Nursery and Clinical Follow Up at 4 Weeks of Age.
Soon Wha Kim, Gyoung Hee Kim, Keun Lee
Clin Exp Pediatr. 1982;25(4):340-346.   Published online April 30, 1982
This study was undertaken to find out the bacteriological colonization of nares and umbilicus of 166 normal fullterm newborns in the nursery of Ewha Womans University Hospital during the period from July 1 to Aug 31. 1980 and its relation with follow up study at the age of 4 weeks. The results are as following: 1) The cultures of nares...
Importance of radiographic study of urinary tract infection in children.
Chang Ho Hong, Kyu Earn Kim, Pyung Kil Kim
Clin Exp Pediatr. 1982;25(4):334-339.   Published online April 30, 1982
In urinary tract infection of childhood, the intravenous pyelogram is helpful in identifying gross malformations of urinary tract and appraising gross renal function. The voiding cystourethrogram evaluates configuration and function of the lower urinary tract and is most useful for delineating the presence and severity of vesicoureteral reflux. The intravenous pyelogram is suggested for every male patients with one documented...