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Original Article
Comparison of Tuberculin Skin Test Results and Adberse Reactions Following BCG Vaccination In Various Infant Groups of Different Ages
In Seung Park, Dong Ki Han, Ho Joon Lim, Sung Hee Oh, Hahng Lee
Clin Exp Pediatr. 1993;36(9):1300-1307.   Published online September 15, 1993
Most authorities including WHO recommended immununizing infants with BCG as early as possible in areas prevalent with tuberculosis, however the optimal time for immunization has not well been characterized. Therefore the investigation was undertaken by vaccinating various infant groups of different ages with BCG and subsequently evaluating for adverse effects and tuberculin reactions, in order to contribute to undestanding the...
Production and Characterization of Monoclonal Antibodies to Perchloric Acid Soluble Antigen of M. tuberculosis(TB-II)
Kyung Hyo Kim, Dong Soo Kim
Clin Exp Pediatr. 1993;36(8):1116-1123.   Published online August 15, 1993
Mycobacteria cause diseases which occur the world over and whoich carry a considerable burden in morbidity, mortality and social problems. A battery of monoclonal antibodies specific for mycobacterial antigens would provide a useful tool for rapid diagnosis of mycobacterial diseases. Fourtenn monoclonal antibodies to perchloric acid soluble antigne of M. tuberculosis were produced. Immunoglobulin isotypes of monoclonal antibodies were ten...
Production, Characterization, and Clinical Application of Perchloric Acid Soluble M. tuberculosis Antigen (TB-I)
Kyung Hyo Kim, John Linton, Yunsop Chong, Dong Soo Kim
Clin Exp Pediatr. 1993;36(8):1107-1115.   Published online August 15, 1993
The immune response to M. tuberculosis engages T-cell medicated reactions which determine the degree of resistance and also the clinical pattern of disease. Although antibodies produced by the infected host have yet no proven protection, they are appilicable for alternative diagnostic tests in tuberculosis. Preparation of purified antigens from Mycobacteria with specific antigenic determinants would improve serological diagnosis in tuberculosis. The...
Case Report
A Case of Endobronchial Tuberculosis Accompanied with Obstructive Emphysema
Myung Goo Min, Seong Chul Shin, Byeung Ju Jeong, Kyu Earn Kim, Ki Young Lee
Clin Exp Pediatr. 1992;35(8):1113-1117.   Published online August 15, 1992
We experienced a case of endobronchial tuberculosis accompanied with obstructive emphsema which appears just before total atelectasis, in a 4/12 year old male who was admitted to the department of pediatrics, Yonsei university College of Medicine. On chest X-ray, left side total emphysema was found and on bronchogram, punched out defect was noted at the site of the left main...
Original Article
Changes of PPD-Specific Immunoglobulin in Pulmonary Tuberculosis After Treatment.
Ja Young Kim, Mun Hwan Lee, Pyoung Han Hwang, Chan Uhng Joo, Jung Soo Kim
Clin Exp Pediatr. 1990;33(12):1647-1655.   Published online December 31, 1990
The definite diagnosis and precise assessment of response to therapy is still a problem in childhood tuberculosis because these patients rarely produce sputum and if obtained it may be negative. For this reason, diagnosis rely largely on the clinical and X-ray examination, which have a low specificity and high proportion of false positive results. Recently immunologic diagnosis of tuberculosis using enzyme-linked immunosorbent assay (ELISA) was...
A Case of Acute Interstitial Nephritis Associated with Yersinia Pseudotuberculosis Infection.
Keun Hee Chung, Yoo Mee Kim, Mee Won Kim, Soon Gi Kim, Moon Soo Park, Jin Keun Chang
Clin Exp Pediatr. 1990;33(8):1123-1128.   Published online August 31, 1990
Authors recently experienced a case of acute interstitial nephritis associated with Yersinia pseudotuberculosis infection in 10-8/12 year old boy, who was admitted to prolonged high fever. On 3rd hospital day, puffy face and oliguria were noted. BUN and serum creatinine rose to peak level, 94.1 mg/dl and 10.1 mg/dl, respectively on 7th hospital day. After then renal functions were normal- ized gradually without specific...
A case of Erythema Nodosum due to Yersinia Pseudotuberculosis.
Keun Hee Chung, Hong Jong Joo, Yoo Mi Kim, Soon Ki Kim, Moon Soo Park, Jin Keun Chang, Sung Woo Shin
Clin Exp Pediatr. 1990;33(4):528-533.   Published online April 30, 1990
Yersinia pseudotuberculosis infection is one of the common causes of erythema nodosum in Europe, but in Korea only 2 cases have been reported. Recently authors experienced a 6 year old boy who suffered from erythematous painful skin lesions on the shin and calf, and was diagnosed serologically as erythema nodosum due to Yersinia pseudotuberculosis infection. So we report here the clinical findings of this...
A case of Endobronchial Tuberculosis Accompanied by Embedded Lymph Node.
Kyoung Hoon Choi, Jeong A Hwang, Byeung Ju Jeong, Kyu Earn Kim, Ki Young Lee, Fan Chen Mong, Hee Dae Park
Clin Exp Pediatr. 1990;33(3):386-392.   Published online March 31, 1990
We experienced a case of endobronchial tuberculosis accompanied by an embedded lymph node in a 1 3/12-year old male who was admitted to the Department of Pediatrics, Yonsei University College of Medicine. On bronchogram, a punched out defect was noted at the site of the right main bronchus from where the right upper lobe bronchus and right intermediate bronchus branched. Although bronchoscopy was performed three...
An Outbreak of Yersinia pseudotuberculosis Infection.
Hong Jong Joo, Keun Hee Chung, Yoo Mee Kim, Soon Gi Kim, Moon Soo Park, Jin Keun Chang, Sung Woo Shin
Clin Exp Pediatr. 1990;33(3):341-350.   Published online March 31, 1990
We experienced one outbreak of Yersinia pseudtuberculosis infection that had not been reported in our country. In May, 1988, an outbreak of acute infection with symptoms suggestive of Yersinia pseudotuber- culosis infection occurred among a middle school students in No-Won-Gu, Seoul. Two hundreds and fifteen students went on a picnic at the Mt. Surak in No-Won-Gu on 13th May, 1988. Fifty of 95 students who...
The Abeominal Tuberculosis in Children.
Young Sik Kim, Jeong Hun Ha, Jeong Kee Seo
Clin Exp Pediatr. 1988;31(12):1594-1602.   Published online December 31, 1988
following results were obtained through the clinical review of 29 cases with the abdominal tuberculosis under the age of 15 years, who admitted to Seoul National University Hospital from January, 1977 to December, 1987. 1) Thirteen cases were patients with tuberculous peritonitis, 12 cases were patients with intestinal tuberculosis, and the remaining 4 cases were patients with both tuberculous peritonitis and intestinal tuberculosis. 2) The male to...
A Case of Intestinal Tuberculosis with Huge Retroperitoneal Tuberculous Lymphadenitis Simulating Neoplasm.
Yong Suk Kim, Dong Seok Choi, Keon Su Rhee, Young Hun Chung
Clin Exp Pediatr. 1988;31(10):1385-1389.   Published online October 31, 1988
Since the advent of effective antituberculous chomtherapy in the 1940s, the frequency and severity of intestinal tuberculosis have markedly decreased. But the incidence of tuberculous disease is still high in Korea. We have recently experienced a cases of intestinal tuberculosis with huge retroperitoneal tuberculous lymphadenitis simulating neoplasm in 2 year 3 month old female. The cases was reported with the brief review of literatures.
4 Cases of Non-Hematogenous Disseminated Pulmonary Tuberculosis.
Mi Ja Yoon, Myung Soo Chang, Bok Lyun Kim, Shin na Kim, Hae Soon Chang
Clin Exp Pediatr. 1988;31(9):1225-1231.   Published online September 30, 1988
Unlike hematogenous spread in miliary tuberculosis, disseminated pulmonary tuberculosis is considered to be spread by non-hematogenous transbronchial with characteristic chest X-ray appear- ance. This type of spread is unusal in childhood pulmonary tuberculosis. We are reporting 4 such cases from 1984 to 1986 with chest X-ray findings. In city hospital where most patients come from low-income families, we see significant number of children with various types...
Case Report
A Case of Cryptococcosis with Advanced Pulmonary Tuberculosis.
Hi Ju Park, Yong Joon Kim, Sang Kun Jung, Chan Yung Kim
Clin Exp Pediatr. 1986;29(1):95-100.   Published online January 31, 1986
This is a case of cryptococcosis accompanied by pulmonary tuberculosis and malnutrition. The 11-year-old female patient was admitted to our hospital because of dyspnea, ascites and oliguria. Cervical lymph node biopsy and chest X-ray were checked, which were revealed tuberculous lesions. She was treated with amphotericin-B for 10 weeks, but didn*t complete remission at present.
Original Article
Clinical Review of Tuberculosis in Childhood.
Hyung Ja Park, Soon Wha Kim, Don Hee Ahn, Keun Chan Sohn
Clin Exp Pediatr. 1985;28(12):1196-1206.   Published online December 31, 1985
A clinical review was made on 202 cases of tuberculosis who had been admitted at Pediatric department, National Medical Center during the period of 5 years and 6 months from January, 1979 to June 1984. The following results were obtained： 1)Annual incidence seemed to be slightly increased during this period. 2)The highest age incidence was in the group of 1 to...
Case Report
Three Cases of Renal Tuberculosis in children.
Young Hwa Joung, Kyoung Soo Kim, Sung Won Kang, Kyu Hong Cho, Byung Churl Lee
Clin Exp Pediatr. 1985;28(9):916-921.   Published online September 30, 1985
Kidney tuberculosis is serious complication during childhood just as later life because the disease tends to invade and to destroy both kidney. We reported three cases of renal tuberculosis in 8-yr-old female, 10-yr-old female and 6- yr-old male child. Case 1 and 3 had complaints of continuous fever and poor appetite and case 2 had complaints of dysuria and urinary...
A case of congenital tuberculosis.
Mee Hye Kim, Hyuk Choul Kwon, Young Il Park, Sang Woo Kim
Clin Exp Pediatr. 1985;28(2):169-173.   Published online February 28, 1985
We experienced a case of congenital tuberculosis in a 10-month-old female patient who had disseminated tuberculosis. She was the 1st born of 30-year-old woman who was diagnosed as tuberculous pleurisy on the 12 th day after delivery. Congenital tuberculosis was suspected because of detection of AFB in gastric aspirates on the 60 days of life. But the treatment was discontinued after...
Original Article
Clinical and Epidemiological Studies on 113 cases of Miliary Tuberculosis in Korean Children.
H S Kim, H I Lee, S H Kim, T C Kwon, C M Kang
Clin Exp Pediatr. 1984;27(8):786-794.   Published online August 31, 1984
Clinical and epidemiological studies were conducted on 113 cases of miliary tuberculosis under the age of 15 years who were admitted to the Pediatric Department of Keimyung University Hospital for the past 15 years from January 1967 to December 1981. The results were as follows: There was no significant change in annual incidence. The majority of the patients(88%) were under...
Case Report
A Case of Renal Tuberculosis in a Child.
Min Young Cha, Se Yun Eun, Chong Guk Lee, Sang Il Lee, Sang Woo Kim
Clin Exp Pediatr. 1984;27(7):733-737.   Published online July 31, 1984
We reported a case of renal tuberculosis in a 10-yr-old male child. He had complaints of dysuria and urinary frequency which were not improved through anappropriate antibiotics medication for 6 months. The diagnosis was confirmed by Ziehl-Neelson staining of urinary sedimentwas, I.V.P. and cystoscopy. A brief review of literatures was presented.
Original Article
A Clinical Study on he Intestinal Tuberculosis in Children.
Young Ran Choi, Youn Ha Kang, Young Min Ahn, Kyo Sun Kim, Jung Kee Seo
Clin Exp Pediatr. 1983;26(11):1063-1069.   Published online November 30, 1983
The following results were obtained through the clinical review of 24 cases with the intes- tinal tuberculosis under the age of 15 years which were treated at Seoul National University hospital and Kangnam General Hospital Public Corporation during the period of 6 years from January, 1977 to December, 1982. 1) The peak incidence was noted in the group aged 12 〜 15 years. The ratio...
Statistical Analysis of 1,349 Cases of In-Patients with Various Tuberculosis in Korea.
Jin Woo Hahn, Jae Hoon Shin, Woo Gill Lee
Clin Exp Pediatr. 1983;26(8):778-785.   Published online August 31, 1983
We studied retrospectively the charts of 1,162 in-patients (that is 1,349 lesions) under 20 years of age who were hospitalized with various tuberculosis in Hanyang University Hospital from May 1972 to December 198L The results of the observation are as follows: 1. Annual distribution of 1,162 patients with tuberculosis revealed little fluctuation over the years. 2. The age and sex distribution of tuberculosis is as follows: The...
A Clinical Study of The Bone and Joint Tuberculosis in Childrens.
Byung Hwa Park, Jung Tae Kim, Byung Ryoung Lee, Tae Ju Hwang, Hyung Suk Byun, Chull Sohn
Clin Exp Pediatr. 1982;25(11):1141-1149.   Published online November 30, 1982
.The following results were obtained through the clinical review of 153 cases of bone and joint tuberculosis which were treated at Mokpo Children’s T.B. Hospital during the period of 10 years from Jaunary 1971 till December 1980. 1. The bone and joint tuberculosis was 10.3% of total tuberculous children during the above period. 2. The peak incidence was noted in the group aged 1 〜3 years and...
Clinical Study on Tuberculosis in Infancy and Early Childhood.
Kong Youb Han, Ki Hyun Yoon, Kyung Hae Park, Sung Hwan Kim, Chan Yung Kim
Clin Exp Pediatr. 1982;25(8):807-815.   Published online August 31, 1982
The following result were obtained through the clinical review of 78 cases with severe tuberculosis under the age of 5 years admitted at Department of Pediatrics, busan National University Hospital during the period of january, 1974 through December, 1980. 1) Incidence of severe tuberculosis in infancy and early chilhood is noticed as 49.3% in tuberculous menigitis, 16.0% in miliary tuberculosis...
Case Report
A Case of Disseminated Cryptococcosis with Skin Lesion and Miliary Shadows of the Lung.
Chan Ho Bang, Sang Keun Chi, In Ho Kim, Sang Woo Kim, Ill Hyang Ko
Clin Exp Pediatr. 1982;25(4):399-403.   Published online April 30, 1982
A Case of disseminated cryptococcosis in a 5-year old girl is reported. Although twenty four pediatric cases of cryptococcosis were reported in Korea for the past 15years, this case's clinical picture is interesting and make diagnostic difficulties from miliary tuberculosis. She was transferred from a local clinic under the impression of miliary tuberculosis with chest X-ray showing miliary shadows. Mantoux...
Original Article
A Clinical Review of Miliary Tuberculosis in Children.
You Nam Kim, Seung Joon Park, Heung Kyu Kim, Ki Bok Kim
Clin Exp Pediatr. 1982;25(4):363-372.   Published online April 30, 1982
A Clinical study was made of 88 pediatric patients with miliary tuberculosis, who were admitted to the Pediatric Department of Kwangju Christian Hospital during the period of January, 1971 through December, 1980. 1) The incidence of miliary tuberculosis in children was 0.6%(88 cases) of the total pediatric admission cases(13969), and 12.5% (88 cases) of the total pediatric tuberculous patiens(705). 2)...
Effects of Rifampin(RMP) on Liver Function in Tuberculous Children.
Hyun Ju Oh, Hyang Suk Yoon, Hyung Suk Bynn, Kyung Yong Huh, Chull Sohn
Clin Exp Pediatr. 1981;24(5):430-436.   Published online May 15, 1981
To evaluate the hepatotoxicity of RMP in tuberculous children during treatment, liver function tests were performed regularly in 40 children who visited or admitted in Chonnam University Medical School Hospital and Mok-po Children's Tuberculosis Hospital from January 1979 to August 1980. The subjects were divided into three groups according to the administered regimens which were INH+EMB or PAS, INH+RMP(10??15mg/kg) and...
Clinical Review of Tuberculosis in Childhood.
Hye Ran Lee, Woon Sik Kim, Don Hee Ahn, Keun Chan Sohn
Clin Exp Pediatr. 1981;24(4):319-328.   Published online April 15, 1981
A clinical review was made on 152 cases of tuberculosis who had been admitted at pediatric department, National Medical Center during the period of 10 years from January, 1969 to December, 1978. The following results were obtained. 1.There noted no difference of annual incidence throughout the study years. 2. The highest age incidence was in the group of 1 to 3 years...