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Purpose : In order to elucidate the neurotoxic mechanism of oxygen radicals which
are pathological factor of ischemia, we evaluated the oxidant-induced neurotoxicity and
the neuroprotective effect of antioxidant on cultured cerebral neurons derived from
neonatal mouse.
Methods : Neurotoxic effect was investigated after cultured mouse neuronal cells were
exposed to oxygen radicals which were generated enzymatically by reaction of xanthine
oxidase(XO) and hypoxanthine(HX). And also... |
