Clinical and Experimental Pediatrics

Original Article

Developmental and Behavioral Medicine

Neonatal risk factors associated with attention-deficit/hyperactivity disorder: an umbrella review

Ensiyeh Jenabi, Erfan Ayubi, Sajjad Farashi, Saeid Bashirian, Fereshteh Mehri

Clin Exp Pediatr. 2023;66(10):441-446. Published online July 14, 2023

Question: The risk factors for attention deficit hyperactivity disorder (ADHD), such as breastfeeding, congenital heart disease, and low birth weight, in neonates are not well understood.
Finding: This umbrella review obtained significant effect sizes for ADHD for congenital heart disease (odds ratio [OR], 3.04), low birth weight (OR, 2.25), never breastfed (OR, 1.55), and Apgar score (OR, 1.30).
Meaning: Congenital heart disease, low birth weight, lack of breastfeeding, and Apgar scores were significant factors for ADHD.

DOI: https://doi.org/10.3345/cep.2022.01396

Neurobehavior

Association between previous abortion history and risk of autism spectrum disorders among offspring: a meta-analysis

Ensiyeh Jenabi, Erfan Ayubi, Saeid Bashirian, Mahdieh Seyedi, Mohammad Rezaei

Clin Exp Pediatr. 2023;66(2):70-75. Published online August 17, 2022

Web of Science 2 Crossref 2

Question: This study aimed to determine whether there is an association between previous abortion history and the risk of autism spectrum disorders (ASDs) among children.
Finding: We found that the risk of ASD associated with previous abortion history had an odds ratio of 1.64 (95% confidence interval, 1.28–2.0; I²=61.7%).
Meaning: These findings suggest a positive and significant association between history of previous abortion and risk of ASD in children.

DOI: https://doi.org/10.3345/cep.2022.00108

Developmental and Behavioral Medicine

Is meconium exposure associated with autism spectrum disorders in children?

Ensiyeh Jenabi, Erfan Ayubi, Salman Khazaei, Saeid Bashirian, Mojtaba Khazaei

Clin Exp Pediatr. 2021;64(7):341-346. Published online October 4, 2020

• Meconium exposure is weakly associated with an increased risk of autism spectrum disorder (ASD) development in children.
• More evidence based on large prospective cohort studies is required to conclude whether meconium exposure is associated with an increased risk of ASD.

DOI: https://doi.org/10.3345/cep.2020.01053

Review Article

General Pediatrics

Association between maternal smoking during pregnancy and risk of bone fractures in offspring: a systematic review and meta-analysis

Erfan Ayubi, Saeid Safiri, Kamyar Mansori

Clin Exp Pediatr. 2021;64(3):96-102. Published online February 5, 2020

Web of Science 8 Crossref 10

Question: What is the effect of maternal smoking during pregnancy (MSDP) on the risk of bone fractures in the offspring?
Finding: After the adjustment for misclassification, MSDP may be associated with a 27% increased risk of bone fracture in the offspring (pooled odds ratio, 1.27; 95% confidence interval, 1.00–1.62; I²=0%; P=0.537)
Meaning: Preventive measures and health education programs should be designed and implemented to encourage women to stop smoking, especially during.

DOI: https://doi.org/10.3345/cep.2019.01466

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