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Cyclosporin A Treatment of Minimal Change Nephrotic Syndrome and Focal Segmental Glomerulosclerosis

Journal of the Korean Pediatric Society 1993;36(12):1740-1746.
Published online December 15, 1993.
Cyclosporin A Treatment of Minimal Change Nephrotic Syndrome and Focal Segmental Glomerulosclerosis
Ik Jun Lee
Department of Pediatrics, Catholic University Medical College, Seoul, Korea
소아의 미세변화 신증후군 및 국소분절성 사구체경화증에 있어서 Cyclosporin A의 치료
이익준
가톨릭대학교 의과대학 소아과학교실
Abstract
In this study I assesed the efficacy and tolerance of cyclosporin A (CyA) in the treatment of steroid-dependent MCNS (minimal change nephrotic cyndrome) and steroid resistant FSGS (focal segmental glomerulosclerosis). The results showed, that 1) CyA was effective in sustaining a remission in steroid-dependent MCNS without prednisone treatment, and therefore, could be an alternative therapeutic choice. 2) After discontinuation of CyA, relapses reccurred as frequently as before, and the children remained steroid responsive. 3) In steroid resistant FSGS the CyA treatment was followed by a partial remission (normalization of serum albumin) in 2 out of 7 patients, and proteinuria was diminished in most cases. However, no complete remission with loss of proteinuria was observed. 4) CyA treatment was well tolerated, especially signs of definitive nephrotoxicity were not observed. It was remarkable, that the well being of all patients improved markedly under CyA treatment and that a normal growth was achieved.
Key Words: Steroid-dependent minimal change nephrotic syndrome (MCNS), Steroid-resistant focal segmental glomerulosclerosis (FSGS), Steroid-resistant focal segmental glomerulosclerosis (FSGS), Cyclosporin A


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