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Immunologic Function in Early Phase of Various Glomerulonephritis.

Journal of the Korean Pediatric Society 1987;30(7):735-741.
Published online July 31, 1987.
Immunologic Function in Early Phase of Various Glomerulonephritis.
Soon Don Hong, Hyoung Soo Cho, Chang Il Ahn
Department of Pediatrics, Kyung Hee University, School of Medicine
각종 사구체신염의 발병초기에 있어서 면역학적 기능에 관한 연구
홍순돈, 조병수, 안창일
경희대학교 의과대학 소아과학교실
Abnormal lymphocyte function has been postulated to have a pathogenetic role in nephrotic syndrome. To assess immunologic parameters in the pathogenesis of various glomerulonephritis in early phase, in prdiatric department of Kyung Hee University Hospital from September 1985 to June 1986, serum immunoglobulin concentration and T cell subsets were measured in 32 children and compared with normal control group (n=30). Further studies are needed to evaluate immunologic parameters in glomerulonephritis, but our study shows as follows: 1) The OKT4/OKT8 ratio increased in post streptococcal glomerulonephritis, minimal change nephrotic syndrome and IgA nephropathy compared to normal control group, but statiscally no significance. 2) Serum IgG level was significantly reduced in minimal change nephrotic syndrome, but the others immunoglobulin level were within normal limit.
Key Words: 0KT4, 0KT8, Immunoglobulin, Glomerulonephritis

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