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L-asparaginase is known as an effective anticancer drug in the induction chemotherapy of acute
lymphocytic leukemia. The side effects or toxicities of L-asparaginase and prednisolone are hypersen-
sitivity reaction, hepatotoxicity, pancreatitis and transient diabetes mellitus, CNS toxicity, disorder
of coagulation system and mild cytotoxicity.
We experienced a case of transient diabetes mellitus and diabetic ketoacidosis induced by L-
asparaginase, prednisolone, vincristine and MTX administration in... |
