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Clinical chemotherapy refractoriness is characterized by resistance to multiple drugs. Multidrug
resistance(MDR) is caused by over-reactivity of a unidirectional drug efflux pump, transmembrane
glycoprotein(P-glycoprotein), which is encoded by the MDR1 gene. P-glycoprotein leads to increased
drug efflux and decreased intracellular drug concentration. Clinical trials that attempt to
reverse or modulate MDR have been done. Cyclosporin-A and verapamil are the most extensively
studied agents and several... |
