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Original Article

Inhibitory effects of several drugs to intestinal secretory stimulation of heat-labile enterotoxin produced by enterotoxigenic E. coli.

Kyung Rae Moon, Sang Kee Park, Young Wook Chun, Kap Seung Kim, Young Bong Park, Young Cheon Na, Jeong Hyung Park, Hyun Kook Lee, Nam Ung Yang

Clin Exp Pediatr. 1991;34(9):1231-1239. Published online September 30, 1991

For exploitation of new antidiarrheal agents to heat-labile enterotoxin (LT) produced by enterotox- igenic E. coli, we have tested several drugs by rabbit ileal loop assay and obtained some significant results. L-glutathione (20 mg), P-chloromercuriphenyl sulfonic acid (20 mg) and water heating extract of Prunus mume (20 mg) reduced LT-mediated intestinal fluid secretion in rabbit ileal loop assay by 92%, 87%, 92% respectively. Maleate,...

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