Clinical and Experimental Pediatrics

Original Article

Short term outcomes of topiramate monotherapy as a first-line treatment in newly diagnosed West syndrome

Gyu Min Lee, Kyung Suk Lee, Eun Hye Lee, Sajun Chung

Clin Exp Pediatr. 2011;54(9):380-384. Published online September 30, 2011

Purpose

To investigate the efficacy of topiramate monotherapy in West syndrome prospectively.

Methods

The study population included 28 patients (15 male and 13 female children aged 2 to 18 months) diagnosed with West syndrome. After a 2-week baseline period for documentation of the frequency of spasms, topiramate was initiated at 2 mg/kg/day. The dose was increased by 2 mg/kg every week to a...

DOI: https://doi.org/10.3345/kjp.2011.54.9.380

Sang-Nam Bae, Bong-Seok Choi, Sang-Ook Nam, Hee-Ju Park

Clin Exp Pediatr. 2001;44(11):1269-1277. Published online November 15, 2001

Purpose : This study was undertaken to investigate factors related to weight changes in children treated with vigabatrin(VGB). Methods : We have analyzed mean weight standard deviation scores(SDS) retrospectively and interviewed 35 childhood epileptic patients attending Pusan National University Hospital on VGB monotherapy followed over 36 months. Putative risk factors including sex, age, duration of VGB administration, mean weight SDS...

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Side Effects of Antiepileptic Drug in Children

Ick-Jin Song, Sang-Ook Nam

Clin Exp Pediatr. 1999;42(11):1559-1566. Published online November 15, 1999

Purpose : The purpose of this study is to estimate the side effects of antiepileptic drug(AED) in children. Methods : Subjects were 267 children who had received AED for at least 1 month during January 1995 to July 1998. We reviewed their sex, age at start of seizure onset, age at medication, class and number of AED, developmental delay, type and...

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The Side Effects of Antiepileptic drugs in Epileptic Children Treated withMonotherapy

Kon-Hee Lee, Hae-Sun Yoon

Clin Exp Pediatr. 1993;36(3):320-327. Published online March 15, 1993

The goal of therapy of epileptic children is to control of seizures with minimal side effects of antiepileptic drug(AED). The relationship between side effects, serum levels and doses of AED were examined prospectively in 72 epileptic children who received monotherapy with phenobarbital, phenytoin, valproate, or carbamazepine for 6 to 26 months. Our results were as follows: 1) Side effects were observed in...

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