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Original Article

A case of transient diabetes mellitus and diabetic ketoacidosis induced by L-asparaginase and prednisolone administration in a patient with relapsed acute lymphocytic leukemia.

Won Kyu Choi, Mee Kyung Namgoong, Har Yong Lee, Hwang Min Kim, Jong Soo Kim

Clin Exp Pediatr. 1991;34(9):1316-1322. Published online September 30, 1991

L-asparaginase is known as an effective anticancer drug in the induction chemotherapy of acute lymphocytic leukemia. The side effects or toxicities of L-asparaginase and prednisolone are hypersen- sitivity reaction, hepatotoxicity, pancreatitis and transient diabetes mellitus, CNS toxicity, disorder of coagulation system and mild cytotoxicity. We experienced a case of transient diabetes mellitus and diabetic ketoacidosis induced by L- asparaginase, prednisolone, vincristine and MTX administration in...

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