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Original Article

Neonatology (Perinatology)

The protective effect of CXC chemokine receptor 2 antagonist on experimental bronchopulmonary dysplasia induced by postnatal systemic inflammation

Seung Hyun Lee, Chang Won Choi

Clin Exp Pediatr. 2021;64(1):37-43. Published online July 15, 2020

Web of Science 3 Crossref 3

Question: Can CXC chemokine receptor 2 (CXCR2) antagonist preserve alveolarization by attenuating the inflammation induced by systemic lipopolysaccharide (LPS) administration in a rat model of bronchopulmonary dysplasia (BPD)?
Finding: CXCR2 antagonist significantly decreased neutrophil counts in bronchoalveolar lavage fluid and peripheral blood induced by systemic LPS administration and restored alveolarization in newborn rats.
Meaning: CXCR2 antagonist protected the lungs from the inflammation in a rat model of BPD.

DOI: https://doi.org/10.3345/cep.2020.00381

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