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Original Article
Gastroenterology
Influence of proton pump inhibitor therapy on intestinal inflammation assessed by fecal calprotectin in pediatric patients
Su Yeong Kim, Na Mi Lee, Sin Weon Yun, Soo Ahn Chae, In Seok Lim, Eung Sang Choi, Dae Yong Yi
Clin Exp Pediatr. 2019;62(10):400-404.   Published online July 3, 2019
Background: An increase in the numbers of patients with gastrointestinal symptoms has recently been observed.
Purpose: To investigate the effects of proton pump inhibitor (PPI) therapy on intestinal inflammation in children and adolescents as confirmed by clinical manifestations and objectively assessed by fecal calprotectin (FC) level measurement. Methods: Consecutive children (aged 3–18 years) who presented with gastrointestinal symptoms and were treated with...
Clinical significance of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 and 2 in Kawasaki disease
Ki Wook Yun, Sin Weon Sin, Jung Ju Lee, Soo Ahn Chae, In Seok Lim, Eung Sang Choi, Byoung Hoon Yoo, Mi-Kyung Lee
Clin Exp Pediatr. 2010;53(4):510-518.   Published online April 15, 2010
Purpose : Kawasaki disease (KD) is a systemic vasculitis, a leading cause of pediatric acquired heart disease. Histopathological findings of coronary artery lesion (CAL) in KD indicate destruction of the coronary artery wall with diffuse vasculitis. Matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors (TIMPs) might play central roles in this process. Special attention to MMP-9 has recently been emerging....
Epidemiologic and clinical features in children with acute lower respiratory tract infection caused by human metapneumovirus in 2006-2007
Gwi Ok Park, Ji Hyun Kim, Jae Hee Lee, Jung Ju Lee, Sin Weon Yun, In Seok Lim, Dong Keun Lee, Eung Sang Choi, Byoung Hoon Yoo,, Mi Kyung Lee, Soo Ahn Chae
Clin Exp Pediatr. 2009;52(3):330-338.   Published online March 15, 2009
Purpose : The causes of acute lower respiratory tract infection (ALRTI) are mostly attributable to viral infection, including respiratory syncytial virus (RSV), parainfluenza virus (PIV), influenza virus A/B (IFV A/B), or adenovirus (ADV). Several Korean studies reported human metapneumovirus (hMPV) as a common pathogen of ALRTI. However, studies on seasonal distribution and clinical differences relative to other viruses are insufficient,...
Case Report
A case of herpes zoster in a 4-month-old infant
Ji Hyun Kim, Jung Ju Lee, Sin Weon Yun, Soo Ahn Chae, In Seok Lim, Dong Keun Lee, Eung Sang Choi, Byoung Hoon Yoo
Clin Exp Pediatr. 2008;51(12):1368-1371.   Published online December 15, 2008
Herpes zoster in infancy is very rare but can be developed following intrauterine or postnatal exposure to varicella zoster virus. We report a case of herpes zoster in a 4-month-old male infant. He had no prior history of primary varicella or varicella vaccination. His mother had no history of varicella infection and no contact history with varicella during pregnancy. He...
Original Article
Clinical significance of serum vascular endothelial growth factor in Kawasaki disease
Ho Seok Lee, Sin Weon Yun, Young Soo Jung, Soo Ahn Chae, In Seok Lim, Dong Keun Lee, Eung Sang Choi, Byung Hoon Yoo, Mi Kyung Lee
Clin Exp Pediatr. 2007;50(10):995-1004.   Published online October 15, 2007
Purpose : Kawasaki disease is a systemic vasculitis, leading cause of pediatric acquired heart disease. Vascular endothelial growth factor (VEGF) has functions as vascular permeability factor, plays an important role in coronary artery lesion (CAL). We studied the clinical significance of serum VEGF in Kawasaki disease. Methods : Kawasaki group was 49 patients, and control group was 15 patients. Diagnosis followed...
Effects of electromagnetic stimulation on neurogenesis and neuronal proliferation in rat hippocampal slice culture
Deok-Soo Kim, Eung Sang Choi, Soo Ahn Chae
Clin Exp Pediatr. 2006;49(5):558-564.   Published online May 15, 2006
Purpose : Transcranial electromagnetic stimulation(TMS) is a noninvasive method which stimulates the central nervous system through pulsed magnetic fields without direct effect on the neurons. Although the neurobiologic mechanisms of magnetic stimulation are unknown, the effects on the brain are variable according to the diverse stimulation protocols. This study aims to observe the effect of the magnetic stimulation with two...
Therapeutic Effect of Anti-Rotavirus Chicken Egg Yolk Immunoglobulin(IgY) on Diarrhea by Infection of Rotavirus
In Seok Lim, Ho Seok Lee, Wonyong Kim, Eung Sang Choi, Dong Hyuk Jung, Hoo Kil Jung, Sung Seob Yun, Ho Nam Chun
Clin Exp Pediatr. 2005;48(12):1354-1361.   Published online December 15, 2005
Purpose : Rotavirus is an enteric pathogen that affects millions of children globally each year. But no specific therapy is available for the management of rotavirus diarrhea. Due to the clear need to define improved modality for treatment of rotavirus diarrhea, we evaluated the efficacy of anti- rotavirus IgY in the treatment of infants and children with gastroenteritis. Methods : First,...
The Clinical Significance of Soluble Intercellular Adhesion Molecule-1(sICAM-1) and Soluble Vascular Cell Adhesion Molecule-1(sVCAM-1) in Kawasaki Disease
Kang Won Rhee, Sin Weon Yun, Dong Keun Lee, Eung Sang Choi, Byung Hoon Yoo, Mi Kyung Lee
Clin Exp Pediatr. 2005;48(6):640-648.   Published online June 15, 2005
Purpose : Kawasaki disease(KD) is known as an acute multi-systemic vasculitis with various immunologic abnormalities. Adhesion of leukocyte to endothelial cells is a key event in the sequence of inflammatory response. This study was performed to investigate the clinical significance of serum soluble intercellular adhesion molecule-1(sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in acute and subacute stages of typical...
Case Report
A Case of Teratocarcinoma with Central Diabetes Insipidus
Jong Hoon Kim, In Seok Lim, Eung Sang Choi, Byoung Hoon Yoo
Clin Exp Pediatr. 2004;47(4):453-457.   Published online April 15, 2004
Central diabetes insipidus is a rare disorder that can result as a consequence of diverse etiologies, including malformations, autoimmune, infiltrative(e.g. neoplastic or histiocytosis) or traumatic processes, as well as mutations in the gene encoding arginine vasopressin. Idiopathic central diabetes insipidus is a diagnosis of exclusion, one that has been made less frequently through the decades. Idiopathic central diabetes insipidus in...
Original Article
Comparison of Acute Clinical Features and Coronary Involvement in Patients with Kawasaki Disease between Those Younger and Older than One Year of Age
So Young Kim, Seong Joon Lim, Sin Weon Yun, Dong Keun Lee, Eung Sang Choi
Clin Exp Pediatr. 2002;45(6):773-782.   Published online June 15, 2002
Purpose : To identify the necessity of more reasonable diagnostic criteria and the possibility of early prediction of coronary involvement in the higher risk group, we investigated and compared clinical and laboratory findings in the acute phase and coronary involvements in those younger (n=17) and older(n=53) than one year of age in Kawasaki disease(KD). Methods : Retrospective chart reviews were performed...
Factors Predictive of Response to Interferon-α Therapy in Children with Chronic Hepatitis B
Hong Kwon Kim, Bo Hwa Choi, Kyung Mo Kim, Kyung Hoon Kang, In Seok Lim, Eung Sang Choi
Clin Exp Pediatr. 2000;43(4):514-519.   Published online April 15, 2000
Purpose : The efficacy and safety of interferon-alpha(IFN-α) therapy in children with chronic hepatitis B(CHB) is similar to that of adults. However, little information is available about the predictive factors of response to this therapy in children. The aim of this study was to determine the predictive factors for responsiveness to IFN-α therapy in children with CHB. Methods : The basal...
Apoptosis, P53, bax and Bcl-2 Protein Expressions in Neonatal rat Hippocampus by Kainic Acid-induced Seizure
Shin Weon Yun, Soo Ahn Chae, Eung sang Choi, Byoung Hoon Yoo
Clin Exp Pediatr. 2000;43(1):85-96.   Published online January 15, 2000
Purpose : Apoptosis is a process of active cell death which has been suggested to be part of hippocampal cell loss caused by kainic acid(KA). Immature rats showed higher susceptibility and mortality to KA but did not develop recurrent seizure, long term behavioral or neuropathologic changes. We investigated whether this was due to age-dependent resistance, and elucidated the molecular mechanics which mediate P53-induced apoptosis,...
Clinical Significance of Serum ECP in Mycoplasma Pneumoniae Pneumonia
Young Ghil Rah, Dong Keun Lee, In Seok Lim, Eung Sang Choi, Soo Ahn Chae
Clin Exp Pediatr. 1999;42(5):672-678.   Published online May 15, 1999
Purpose : Allergic inflammation of the lower respiratory tract is a characteristic clinical feature in asthma patients, in which eosinophils play an important role. The activity of eosinophil may be determined by measuring the level of eosinophil cationic protein(ECP) in sputum or serum as a potential marker of the inflammatory severity. Methods : We measured the serum concentrations of ECP...
Prediction of Steroid Responsiveness in the Primary Nephrotic Syndrome Using Urinary β2-Microglobulin Level and N-Acetyl-β-D-Glucosaminidase Activity
Kwang In Lee, In Seok Lim, Eung Sang Choi
Clin Exp Pediatr. 1997;40(9):1285-1292.   Published online September 15, 1997
Purpose : Considering that renal biopsy is not routinely indicated in nephrotic syndrome in children and the risk of the procedure, we studied that it is possible to predict steroid responsiveness in nephrotic syndrome and the difference in responsivenss is related with the histopathologic type using urinary β2-microglobulin and N-Acetyl-β-D-Glucosaminidase activity as a safe and noninvasive method. Methods : We measured serum creatinine, albumin, cholesterol...
A case of malignant atrophic papulosis (Degos' disease).
Sung Ku Lee, In Seok Lim, Chul Ha Kim, Dong Keun Lee, Eung Sang Choi, Byoung Hoon Yoo, Gae Yong Song
Clin Exp Pediatr. 1991;34(12):1724-1729.   Published online December 31, 1991
Malignant atrophic papulosis (Degos’ disease) is characterized by porcelain-white skin lesions. It has unknown etiology and bad prognosis. Death usually occurs from multiple intestinal perforations weeks to years after onset. We experienced a case of Degos’ disease in a 12-year-old male patient who had porcelain white papules on face, trunk and extremities. Histopathologic studies showed broad epidermal necrobiosis with thrombotic arteriolar occlusion. A brief review of...
A Study of Serum Transaminase Level and It's Correlation with Dehydration in Children with HRV Gastroenteritis.
Tae Joon Park, Eung Sang Choi
Clin Exp Pediatr. 1990;33(12):1662-1669.   Published online December 31, 1990
The study was taken to study the serum transaminase level and it’s correlation with dehydration in Human Rotavirus gastroenteritis. 129 children, who admitted to the Department of Pediatrics in Chung-Ang University Hospital from January 1987 to December 1989 with chief complaints of fever, vomiting, and watery diarrhea were included in this studies. The stool specimen on admission was tested for Rotavirus Ag by ELISA method....
Case Report
A Case of Thanatophoric Dwarfism.
Hae Seong Lee, Wha Young Chung, Eung Sang Choi, Tae Sub Shim
Clin Exp Pediatr. 1983;26(9):922-927.   Published online September 30, 1983
Thanatophoric dwarfism is a lethal congenital chondrodystrophy characterized by diminished vertebral body height, a narrow thorax, and micromelia. This report presents the clinical, radiographic and autopsy findings of an experienced case of thanatophoric dwarfism detected prenatally by radiologic examination and discusses the differentiation of this disorder from other forms of congenital short limbed dwarfism.
Two Cases of Pulmonary Sequestrations.
Woong Heum Kim, Ji Suck Chang, Soon Woong Kang, Eung Sang Choi, Yong Su Yoon, Chong Gu Yoon, Kwang Wook Ko
Clin Exp Pediatr. 1982;25(10):1058-1062.   Published online October 31, 1982
We have experienced two cases of pulmonary sequestrations. The first case, 49/I2 year old girl, was admitted for ths evaluation of recurrent pneumonia of left lower lung. The diagnosis of pulmonary sequestration was made by aortography, which demonstrate tortuous aberrant artery suppling the left posterobasal segment from the intrathoracic descending aorta at Tlo 유卜 level, and the sequestration was successfully resected by lobectomy. The...
Aneurysm of the Main Pulmonary Artery-Report of a case and review of the literature.
Eue Cho Yang, Eung Sang Choi, Yong Soo Yoon, Chang Yee Hong, Joon Ryang Roh, Kyung Mo Yeon
Clin Exp Pediatr. 1982;25(2):162-167.   Published online February 28, 1982
Pulmonary artery aneurysms are extremely rate and are seldom diagnosed during life. In true aneurysms, dilatation tends to be confined to the main trunk of the artery and degenerative changes in the wall are found. In 1971, Williams et al reported the first successful excision and replacement of the main pulmonary artery, including the bifurcation, with a dacron graft. Since...
Original Article
Clinical Obseervation for Hematologic Disorders in Children.
Eung Sang Choi, Soon Ung Kang, Jeong Kee Seo, Hyo Seop Ahn, Chang Yoo Hong
Clin Exp Pediatr. 1981;24(3):235-244.   Published online March 15, 1981
Nine hundred and twenty-three cases of hematologic disorders in children who were admi-tted to department of pediatrics, SNUH, from 1955 to Oct. 1980 were analysed. The patients consisted of 624 males and 299 females. The results were as follows; 1.Mean annual percentage of hematologic patients among total admitted patients was 6.8%. 2.The peak age incidence of various hematologic disorders was...
Total Serum bilirubin concentration of Physiologic Jaundice of Healthy, full-term Infants.
Eung Sang Choi, Chang Hyo Lee, Chong Ku Yun
Clin Exp Pediatr. 1980;23(2):111-117.   Published online February 15, 1980
The bilirubin formed in utero by the fetus can cross the placena and be excreted by the maternal liver. After birth, however, the infant must excrete its own bilirubin and hepatic clearance is not sufficient to prevent its accumulation during first week of life This transition has been physiologic jaundice and defined as an elevation of serum bilirubin that does...
The Time of the First Stool and Urine by the Low Birth Weight, Premature Infant.
Chong Ku Yoon, Eung Sang Choi
Clin Exp Pediatr. 1979;22(11):947-955.   Published online November 15, 1979
The times of passage of the first stool and urine in the newborn infant are important because delayed micturition may indicate urinary tract pathology and failure to pass meconium may be an early sign of intestinal obsturuction. Times of first void and first stool in 180 consecutive low birth weight, premature infant born at Seoul National University Hospital during 44...