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Original Article
The effect of Lantus on glycemic control in children and adolescents with type 1 diabetes mellitus
Young Jun Rhie, Hyun Wook Chae, Ho Seong Kim, Duk Hee Kim
Clin Exp Pediatr. 2007;50(6):565-569.   Published online June 15, 2007
Purpose : With a duration of action of approximately 24 hours and peakless levels, Lantus is a more physiologic basal insulin analogue compared with NPH. The aim of this study was to compare the glycemic control of Lantus plus Humalog with that of premixed insulin in children and adolescents with type 1 diabetes mellitus. Methods : The subjects consisted of...
Serum Ferritin as a Risk Factor in Type 2 Diabetes Mellitus
Jung Hyun Kim, Ho Seong Kim, Duk Hee Kim
Clin Exp Pediatr. 2005;48(11):1239-1243.   Published online November 15, 2005
Purpose : Iron accumulation interferes with hepatic insulin extraction and affects insulin synthesis and secretion. The purpose of this study is to investigate the correlation between serum ferritin and type 2 diabetes mellitus. Methods : We compared the serum ferritin level among 18 patients in an impaired glucose tolerance (IGT) group, 36 in a type 1 diabetes group, eight in...
Prevalence of the Nonalcoholic Fatty Liver Disease in Obese Children
Sung Woog Hwang, Duk Hee Kim, Ho Seong Kim
Clin Exp Pediatr. 2005;48(1):13-20.   Published online January 15, 2005
Purpose : Obesity is, along with metabolic syndrome, closely related with nonalcoholic fatty liver disease. This study tried to evaluate the prevalence of nonalcoholic liver disease in obese children and verify the factors associated with the disease. Methods : Two hundred and seventy nine children who showed a body mass index of 95 percentile over the baseline in health examinations...
Evaluation of Health Status and Growth and Developmental Outcome of Intrauterine Growth-Retarded Infants
Il Tae Hwang, Eun Ae Park, Ho Seong Kim, Gyoung Hee Kim
Clin Exp Pediatr. 2001;44(6):635-641.   Published online June 15, 2001
Purpose : Although many children born with intrauterine growth retardation demonstrate significant catch-up growth in early childhood, substantial weight and height deficits remain in others. In addition, children with IUGR may demonstrate developmental deficits. The aims of this study are to evaluate the health status, growth and deveolpmental outcome of intrauterine growth retarded infants. Methods : Sixty five intrauterine growth retarded...
Comparison Between 24-hour Integrated Growth Hormone Concentrations and Pharmacological Provocation Tests in Children with Short Statue
Mi Jung Park, Duk Hi Kim, Ho Seong Kim
Clin Exp Pediatr. 1995;38(6):835-842.   Published online June 15, 1995
Purpose : The ability to respond to pharmacologial provovation tests may not necessary reflect actuaol secretory patterns of growth hormone. Therefore, the aim of this study in to evaluate the 24-h IC-GH and compare this with their resposnses to standard pharmacological provocation tests for growth hormone comcentrations and to evaluate peak frequency and peak amplitude during 24-h IC-GH in children...
Incidence and Complications of Obesity in Pubescent School Children
Boo Hyun Han, Duk Hi Kim, Yoo Kyung Park, Jong Ho Lee, Ho Seong Kim
Clin Exp Pediatr. 1995;38(4):520-528.   Published online April 15, 1995
Purpose : In recent years, obesity in children has become one of the major nutritional problems, and the trend is that number of obese children is increasing. The purpose of this research is to examine the incidence of obesity in pubescent school children in Seoul and Cheju, and to analyze body fat component, complications and eating habits of those obese...
Body Composition of Children and Adolescents with Insulin-dependetn Diabetes Mellitus
Hye Young Kang, Mi Jung Park, Duk Hi Kim, You Kyung Park, Jong Ho Lee, Ho Seong Kim
Clin Exp Pediatr. 1994;37(12):1709-1716.   Published online December 15, 1994
Bodycomposition measurement is useful in the diagnosis of pathoogy, assessment of disease process and response to treatment in many endoclonologic and metabolic diseases. The Techniques used currently are mostly indirect, often expensive, difficult and time-consuming. A new method for estimation of body composition, infrared interactance, is rapid, safe, noninvasive, and may be useful in research ad clinical studies. Body composition was...
Case Report
One Case of Maffucco's Syndrome with Testicular Teratoma
Seung Mo Park, Duk Hi Kim, Ho Seong Kim
Clin Exp Pediatr. 1994;37(8):1162-1168.   Published online August 15, 1994
Maffucci's syndrome is a very rare, congenital and non-hereditary mesodermal dysplasia manifested by multiple enchondromas and soft tissue hemangiomas. Since Maffucci had reported this syndrome in 1881, there have been more than 100 cases reported, and also there has been reported that Maffuddi's syndrome has various interstitial tumor. However there hasn't been any report about Maffucci's syndrome with testicular teratoma....
Original Article
Mechanism of Impaired Growth Hormone Response in Children with Simple Obesity
Moon Sung Park, Mi Jung Park, Ho Seong Kim, Duk Hi Kim
Clin Exp Pediatr. 1994;37(4):457-463.   Published online April 15, 1994
Obesity is associated with an impairment of the hormone secretion elicited by all stimuli known to date, but the basic mechanism of this alteration is unknown, To determine whether obesity is associated with a chronic state of tonic somatostatin, several tests with growth hormone stimuli such as GHRH (1㎍/kg), clonidine (150㎍/m2) and Resular insulin (0.1U/kg, subcutaneously), to obese subjects and...
The Effect of Testosterone on the Response of Grow Hormone Secretion in Cultured Rat Pituitary Cells
Ho Seong Kim, Duk Hi Kim, Deok Bae Park
Clin Exp Pediatr. 1993;36(11):1578-1582.   Published online November 15, 1993
The effects of testosterone on the pituitary growth hormone(GH) response directly and to hypothalamic growth hormone-releasing hormone(GHRH) were evaluated in vitro using a male pituitary cell monolayer culture system. Wistar male rats were gonadectomized at 22 days of age, and 21 days later their anterior pituitaries were removed and trypsinized for cell dispersion. Testosterone 0.01, 1.0, 10.0nM was added to...
Growth Pattern and Final Height in Congeital Adrenal Hyperplasia
Ho Seong Kim, Duk Hi Kim
Clin Exp Pediatr. 1993;36(10):1359-1365.   Published online October 15, 1993
Clinical characteristics and growth pattern were evaluated in 42 patients with classical congenital adrenal hyperplasia treated since diagnosis. And final height was evaluated in 16 patients who had reached final adult height with regard to clinical form, degree of hormonal control, and age of initial treatment. The results were as follows; 1) Among 42 patients with classical congenital adrenal hyperplasia, the male...
Case Report
Three Cases of Acute Suppurative Thyroiditis in children
Min Joong Kwon, Ho Seong Kim, Duk Hi Kim, Duk Hi Kim
Clin Exp Pediatr. 1993;36(9):1320-1324.   Published online September 15, 1993
Acute suppurative thyroiditis is uncommon in children. The relative rarity of thyroid infection is thought to reflect its complete fibrous encapsulation, generous vascular and lymphatic supply and high local iodine level. the bacterial involvement include the normal oropharyngeal microflora, and broad spectrum antibiotic therapy including anaerobic coverage should be utilized initially. We have experienced three cases of acute suppurative throiditis. All...
Pancreatic Islet-cell Adenoma
Ji Hong Kim, Ho Seong Kim, Duk Hi Kim, Hyun Yee Im, Chan Il Park
Clin Exp Pediatr. 1993;36(6):870-876.   Published online June 15, 1993
Pancreatic islet cell adenoma is a benign tumor of pancreatic β-cell and a rare cause of hyperinsulinemic hypoglycemia in chidren. The autors experienced a case of pancreatic islet cell adenoma(Insulinoam) in a 11 year and 8 month old male who had frequent loss of consciousness and seizuere. Enucleation was done after localiztion of tumor by selective celiac artery angiography and abdominal...
Original Article
Growth Outcome in Congenital Hypothyroidism
Mi Jung Park, Ho Seong Kim, Duk Hi Kim
Clin Exp Pediatr. 1993;36(5):713-720.   Published online May 15, 1993
Congenital hypothyroidism is one of the most common endocrine disease in childhood and it causes not only mental retardation but also growth retardation. There were many papers about evaluation of developmental outcome in congenital hypothyroidism, The aim of this study was to evaluate growth outcome in congenital hypothyroidism. We evaluated 65 patients with congenital hypothyroidism diagnosed at yonsei University College...
Clinical Significance of Urinary Growth Hormone Measurement in patients with Growth Hormone Deficien
Ho Seong Kim, Duk Hi Kim, Min-Seok Cheon
Clin Exp Pediatr. 1993;36(4):478-484.   Published online April 15, 1993
Urinary growth hormone (GH) excretion was quantitated in 12-hr overniaght urine collections obtained from 13 children with complete growth hormone deficiency(CGHD), 6 children with partial growth hormone deficiency(PGHD), 5 children with short stature and normal GH provocation tests(NSC), and 5 normal control children (NC) to investigate whether the measurement of urinary GH can clearly separate the PGHD and CGHD groups...
Case Report
Three Cases of Post-transfusion Hepatitis C
Kyung Un No, Ho Seong Kim, Ji Won Choi, Dong Wook Kim, Cheol Ho Jang, Beom Su Park, Jeong Kee Seo, Gyeong Hoon Kang, Je Geun Chi
Clin Exp Pediatr. 1992;35(9):1255-1262.   Published online September 15, 1992
Hepatitis C virus has been known to be the main cause of post-transfusion non-A, non-B hepatitis. The authors experienced three cases of hepatitis C. All were associated with blood transfusions. They had no specific symptoms, and the levels of aminotransferases were markedly elevated and showed severe fluctuations in two cases. Anti-HCV tested two or three times were all positive, and...
A Case of Primary Hyperparathyroidism in Infancy
Mi Jung Park, Ho Seong Kim, Duk Hi Kim
Clin Exp Pediatr. 1992;35(7):1008-1013.   Published online July 15, 1992
Primary hyperparathyroidism is very rare and often fatal disease in childhood. We experienced a case in which a 4 months old male patient complaning of lethargy, hypotonia, respiratory difficulty showed typical laboratory and radiological findings compatible to primary hyperparathyroidism. He was successfully treated with total parathyroidectoimy with partial parathyroid autotrans-plantation. Thus the case of primary hyperparathyroidism in infancy is presented with...
Original Article
Quantification of Human Urinary Growth Hormone and Its Clinical Significance in the Diagnosis of Growth Hormone Deficiency
Seung Ryul Lee, Ho Seong Kim, Duk Hi Kim, Chang Mi Kim
Clin Exp Pediatr. 1992;35(5):595-601.   Published online May 15, 1992
Twelve-hour nocturnal urine was collecte in 5 patients diagnosed of having complete GH deficiency, 6 of having partial GH deficiency and 7 persons as normal control group. The GH levels in urine collections were evaluated, and the results are as follows. 1) The GH level of normal control group was 16.76¡¾1.91ng/12hr, 59.00¡¾6.92ng/gCr, 16.24¡¾2.52ng/m2, 0.58¡¾0.12ng/kg. 2) The GH level of complete GH deficiency...
The Effects of Testosterone on the Pituitary Growth Hormone Secretion
Ho Seong Kim, Duk Hi Kim, Kyung Za Ryu, Chang Mee Kim, Deok Bae Park
Clin Exp Pediatr. 1992;35(2):174-181.   Published online February 15, 1992
The effects of testosterone on growth hormone secretion and somatic growth have been reported in several previous studies. In order to investigate the role of testosterone in growth hormone secretion, we have studied the effect of testosterone on somatic growth, basal growth hormone concentration, and growth hormone response to growth hormone-releasing hormone (GHRH) in orchiectomized rats. In experiment 1, four groups...
Prolonged Fever in Korean Children: Review of 120 Cases.
Ho Seong Kim, Dong Goo Lee, Dong Soo Kim
Clin Exp Pediatr. 1990;33(11):1516-1525.   Published online November 30, 1990
The authors reviewed the 120 patients with prolonged fever whose temperature was over 38.5°C and of undetermined etiology, who were admitted in Y야isei Medical Center from March 1982 to March 1989. The results were as follows; 1) The children admitted with prolonged fever were 0.3% of total in-patients at the same time. 2) 20 cases were less than 1 year of age on admission and 39...
Lipoid Pneumonia.
Chang Gee Kang, Ho Seong Kim, Jung Tak Kim, Dong Soo Kim, Eun Kyung Han, Kwang Gil Lee, In Joon Choi
Clin Exp Pediatr. 1990;33(3):393-397.   Published online March 31, 1990
Lipoid pneumonia is a chronic, interstitial, proliferative inflammation resulting from aspiration of lipoid material; it occurs principally in debilitated infants. Animal oils, owing to their high fatty acid content, are the most damaging. There are no characteristic signs or symptoms; cough is most common and in severe cases there may be dyspnea. We have experenced one case of lipoid pneumonia cause by an aspiration of...