Clinical and Experimental Pediatrics

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Gastroenterology

Gut microbiota’s impact on obesity

Sujin Jeong

Clin Exp Pediatr. 2023;66(7):294-295. Published online June 14, 2023

Web of Science 1 Crossref 1

· An imbalance of the gut microbiota with a relative increase in Firmicutes versus Bacteroidetes is associated with the pathogenesis of obesity.
· Dysbiosis is associated with microbial genes associated with short-chain fatty acids (SCFA) production and increased colonic SCFA levels. SCFAs have also been shown to regulate appetite and satiety hormones, which can affect food intake and energy balance.
· A dietary high-fat intake is reportedly associated with increased plasma lipopolysaccharide. Altered Toll-like receptor-4 signaling leads to propagating the cascade of further inflammation and promoting insulin resistance.

DOI: https://doi.org/10.3345/cep.2023.00458

Review Article

Gastroenterology

Factors influencing development of the infant microbiota: from prenatal period to early infancy

Sujin Jeong

Clin Exp Pediatr. 2022;65(9):439-447. Published online December 23, 2021

Web of Science 29 Crossref 29

∙ Microbial colonization primarily occurs after birth but there may be some colonization in utero, although this remains highly controversial.
∙ Maternal factors during pregnancy affect the infant microbiota: diet, weight, gestational weight gain, and antibiotic usage.
∙ Microbes are passed from mother-to-infant during and after birth. Delivery mode, breastfeeding, early life antibiotic, and proton pump inhibitor treatment have the largest effects on microbial composition in early life.
∙ The early life gut microbiome plays an important role in the development of the immune system and metabolism.

DOI: https://doi.org/10.3345/cep.2021.00955

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Editorial Office: Korean Pediatric Society
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Clinical and Experimental Pediatrics is an open access journal. All articles are distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/)