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Case Report
A Case of Vascular Leak Syndrome During Induction Chemotherapy of Acute Lymphoblastic Leukemia(T Cell Type)
Kye Wool Kang, Hwang Min Kim, Won Kyu Choi, Baek Keun Lim, Chang Hun Lee
Clin Exp Pediatr. 2001;44(9):1041-1046.   Published online September 15, 2001
Vascular leak syndrome(VLS) is characterized by endothelial damage, which causes extravasation of plasma proteins and fluid from capillaries into the extravascular space. It has been suggested that the increased vascular permeability is the result of an IL-2-induced suppression of endothelin- 1 secretion by endothelial cells, an IL-2-induced activation of the complement cascade or TNF-αrelease from IL-2-activated T-cells. A 13-year-old male patient visited our hospital...
Original Article
Extrachromosome 21 in Korean with Down Syndrome Using DNA Haplotyping
Jin-Sung Lee, Won Kyu Choi
Clin Exp Pediatr. 1997;40(7):917-924.   Published online July 15, 1997
Purpose : Down syndrome, the most common single cause of mental retardation, is usually due to meiotic nondisjunction leading to trisomy 21. In order to understand the mechanisms of meiotic nondisjunction including parental origin of an extrachromosome and the meiotic stage of nondisjunction, we have studied DNA polymorphisms at loci on the long arm of chromosome 21 in 36 families with free trisomy 21. Methods...
Case Report
A Treatment Case with PTCA in Osteal Stenosis of Takayasu's Arteritis
Tae Gyoun Park, Won Kyu Choi, Hae Yong Lee
Clin Exp Pediatr. 1997;40(5):726-729.   Published online May 15, 1997
PTCA was performed in llgears old Takayasu’s arteritis patient with left coronary artery osteal stenosis. A balloon angioplasty catheter was introduced by a 7-F guiding catheter with a 0.14 steerable guide wire. The balloonings were approximately 60 and 80 seconds at each duration. The procedure was performed repeat twice. The stenotic lesion was improved after PTCA. After 2years PTCA, left...
A CaseofNarcolepsy Diagnosed by MultipleSleep Latency Test
Kharp Sue Yoo, Won Kyu Choi, Jae Seung Yang, Jong Soo Kim
Clin Exp Pediatr. 1997;40(2):265-269.   Published online February 15, 1997
Narcolepsy is a serious, lifelong, disabling disorder characterized by a tetrad of symptoms including excessive daytime sleepiness, cataplexy, hypnagogic hallucination, and sleep paralysis. We experienced a 14 year old boy with a narcolepsy diagnosed by typical clinical symptoms above mentioned and multiple sleep latency test. A brief review of the related literatures was also made.
A Case of Common Bile Duct Stone Treatment with Endoscopic Sphincterotomy
Do Yoon Lee, Chang Sun Yoo, Won Kyu Choi, Jae Seung Yang, Jong Soo Kim, Dong Ki Lee
Clin Exp Pediatr. 1996;39(6):856-860.   Published online June 15, 1996
The cholelithiasis and common bile duct(CBD) stone are rare problems among children. Endoscopic retrograde cholangiopancretogram(ERCP) and endoscopic sphincterotomy are rarely commomly utilized in the treatment of children, primarily because there are fewerindications. ERCP is an established procedure for visualization of the biliary tract. Endoscopic sphincterotomy with stone extraction has been accepted as the treatment of choice for CBD stone removal in adults. However, the role...
A Case of Intestinal Tuberculosis with Tuberculous Mesenteric Lymphadenitis Simulating Neoplasm
Jin Young Choi, Won Kyu Choi, Hwang Min Kim, Joong Soo Kim
Clin Exp Pediatr. 1995;38(3):404-408.   Published online March 15, 1995
The incidence of abdominal tuberculosis is decreasing due to more effective chemotherapy and pasteurization of milk and tuberculosis may nt be given serious consideration, especially when the primary pulmonary site is healed or not roentgenographically apparent. The clinical features of these infection are relatively nonspecific and the combination of abdominal mass, weight loss, anorexia and fever frequently lead to an...
Original Article
A Study of Relation between Serum Aminotransferase Elevation and Clinical Symptoms from Human Rotavirus Gastroenteritis
Gee Sun Hong, Hwa Young Jeon, Won Kyu Choi, Mee Kyung Namgoong, Jong Soo Kim
Clin Exp Pediatr. 1995;38(1):54-60.   Published online January 15, 1995
This study was taken to measure the serum aminotransferase level and it's correlation with clinical symptoms from Human Rotavirus gastroenteritis. This report is based on analysis of 434 patients who were admitted to the Pediatric department at Wonju Christian Hospital because of watery diarrhea and vomiting during 2-year period from July, 1991 to June 1993. The stool specimen on admission...
Case Report
Isolated Angiitis of the Central Nervous System
Seon Jin Ji, Jin Young Choi, Won Kyu Choi, Jae Seung Yang, Jong Soo Kim, Myung Soon Kim
Clin Exp Pediatr. 1994;37(9):1286-1291.   Published online September 15, 1994
Isolated angiitis of the central nervous system is a rare clinicopathologic entity characterized by vasculitis restricted to the vessels of the central nervous system without other apparent systemic vasculitis. It manifests headache, higher cortical dysfunction, focal neurologic dysfunction and cranial nerve palsies. We experienced a case of isolated angiitis of the central nervous system in 6 year-old girl who was admitted...
Original Article
Diagnostic Significance of Red Cell Indices in Non-anemic Iron Deficiency and Iron Deficiency Anemia: Reevaluation with ROC Curve
Hwang Min Kim, Won Kyu Choi, Jae Seung Yang, Jong Soo Kim
Clin Exp Pediatr. 1994;37(1):33-39.   Published online January 15, 1994
To validate the diagnostic significance of red cell indices in non-anemic iron deficiency and iron deficiency anemia, complete blood count, serum iron, total iron binding capacity, and serum ferritin were measured in 208 middle school girls between 13 and 15 years age. We used Reciever Operating Characteristic (ROC) curve to compare the diagnostic significances of various red cell indices (MCV,...
Case Report
An autopsy Case of Nonbacterial Thrombotic Endocarditis
Sun Hee Huh, Hae Yong Lee, Won Kyu Choi, Mee Kyung Namgoong, Jong Soo Kim, Mee Yon Cho
Clin Exp Pediatr. 1993;36(6):888-893.   Published online June 15, 1993
We experienced a case of nonbacterial thrombotic endocarditis in a 25-day-old male neonate, who was suffered from ASD, MR and congestive heart failure. He was died suddenly during recovery phase. The Post diagnosis was nonbacterial thrombotic endocarditis. We report with a brief review and its related literatures.
A Case of Percutaneous Transluminal Angioplasty in Takayasu Arteritis
Hyun Cheol Lee, Moon Sang Park, Won Kyu Choi, Mee Kyung Namgoong, Hae Yong Lee, Beak Keun Lim, Hyung Goo Cho
Clin Exp Pediatr. 1993;36(2):280-286.   Published online February 15, 1993
Takayasu arteritis is a chronic inflammatory arteriopathy of unknown etiology affecting large vessels, particulary the aorta and its main branches. We experienced a case of Takayasu arteritis type III in a 9 years old girl. The diagnosis was made by physical examinations and digital subtration aortography(DSA) which showed occulsion of left subclavian artery and left renal artery and stenosis of abdominal...
Original Article
A Study on the Diagnostic Value of Cerebrospinal Fluid Adenosine Deaminase Activity in Children with Tuberculous Meningitis
Won Kyu Choi, Mee Kyung Namgoong, Hae Yong Lee, Hwang Min Kim, Jae Seung Yang, Jong Soo Kim
Clin Exp Pediatr. 1992;35(1):88-97.   Published online January 15, 1992
Tuberculous meningitis is still relatively common infectious disease of central nervous system in korea. The prognosis of tuberculous meningitis is closely related to the state at which treatment if started. Adenosine deaminase (ADA) is an enzyme which irreversibly hydrolyzes adenosine into inosine and ammonia. Recent investigations have suggested that the measurement of ADA activities in cerebrospinal fluid is useful in the...
A case of transient diabetes mellitus and diabetic ketoacidosis induced by L-asparaginase and prednisolone administration in a patient with relapsed acute lymphocytic leukemia.
Won Kyu Choi, Mee Kyung Namgoong, Har Yong Lee, Hwang Min Kim, Jong Soo Kim
Clin Exp Pediatr. 1991;34(9):1316-1322.   Published online September 30, 1991
L-asparaginase is known as an effective anticancer drug in the induction chemotherapy of acute lymphocytic leukemia. The side effects or toxicities of L-asparaginase and prednisolone are hypersen- sitivity reaction, hepatotoxicity, pancreatitis and transient diabetes mellitus, CNS toxicity, disorder of coagulation system and mild cytotoxicity. We experienced a case of transient diabetes mellitus and diabetic ketoacidosis induced by L- asparaginase, prednisolone, vincristine and MTX administration in...