Clinical and Experimental Pediatrics

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Original Article

Effects of Thioredoxin on Apoptosis-Inducing Neuronal Cell Injury

Hyunmi Kim, Gyoung Hee Kim, Yoon Song Lee

Clin Exp Pediatr. 1999;42(6):825-832. Published online June 15, 1999

Purpose : Thioredoxin is an endogenous antioxidant. It regulates the activities of transcriptional factors such as NF-kB(nuclear factor kappa B)and AP-1(activator protein-1) and it increases the synthesis of cytokines, preventing cellular proliferation and apoptosis. The aim of this study was to clarify the role of thioredoxin on apoptosis-inducing neuronal cell injury. We investigated the protective effects of thioredoxin against apoptosis-inducing...

Effects of Thioredoxin on Oxidative Neuronal Cell Injury

Hyunmi Kim, Gyoung Hee Kim, Yoon Song Lee

Clin Exp Pediatr. 1999;42(5):686-696. Published online May 15, 1999

Purpose : Thioredoxin is an endogenous antioxidant which directly scavenges reactive oxygen species(ROS) and regenerates oxidatively damaged protein by reducing potential at the redox active disulfide(-Cys-Gly-Pro-Cys-) site. Under oxidative stress, thiredoxin plays a protective and adaptative role by inducing expressions. The aim of this study was to clarify the role of thioredoxin on oxidative neuronal cell injury. We investigated the...

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