• Search
  • Advanced Search

Search

  • HOME
  • Search
Original Article
Aseptic Meningitis Secondary to High-Dose Intravenous Immunoglobulin Therapy in Kawasaki Disease
Ae Ra Cho, Jee Yoon Park, Kyung Hyo Kim, Young Mi Hong
Clin Exp Pediatr. 2004;47(5):561-566.   Published online May 15, 2004
Purpose : Kawasaki disease is a multisystemic inflammatory vasculitis and associated with neurologic features such as aseptic meningitis. High-dose intravenous immunoglobulin(IVIG) is used to treat Kawasaki disease and generally considered to be safe, but rare cases of aseptic meningitis with unknown etiology have been reported. The aseptic meningitis associated with Kawasaki disease was compared with meningitis as the adverse reaction...
Prediction of Intravenous Immunoglobulin Non-responders in Patients with Kawasaki Disease
Gi Bum Lee, Ji-Won Lee, Kyung-Yil Lee
Clin Exp Pediatr. 2004;47(1):90-94.   Published online January 15, 2004
Purpose : We evaluated the effects of intravenous immunoglobulin(IVIG) on the levels of laboratory indices examined serially according to the responsiveness to IVIG therapy in children with Kawasaki disease(KD). Methods : Children with KD(n=63) who had been treated with IVIG at a dosage of 2.0 g/kg were classified into two groups : the IVIG-resistant(consistent fever over 48 hours after initiation...
Case Report
Arthritis in the Subacute Stage of Kawasaki Disease after Responding to Intravenous Immunoglobulin Treatment
Kyung-Yil Lee, Jin-Hee Oh, Dea-Kyun Koh
Clin Exp Pediatr. 2003;46(11):1124-1127.   Published online November 15, 2003
We evaluated the clinical and laboratory characteristics of five children with Kawasaki disease who had showed arthritis after responding to intravenous immunoglobulin(IVIG) treatment. Age distribution was between 13 months and six years of age(mean 3.2?.6 years). There were two males and three females. Arthritis occurred when acute symptoms were subsiding, with the average onset on day 5.8?.8 after final IVIG...
A Case of Henoch-Schonlein Purpura Nephritis Complicating Encephalopathy Accompanied by Hypertension and Cerebral Vasculitis
Hee Ra Choi, Eo Jin Kim, Myoung Bum Choi, Jae Young Lim, Chan Hoo Park, Hyang Ok Woo, Hee Sang Youn
Clin Exp Pediatr. 2003;46(10):1040-1043.   Published online October 15, 2003
Henoch-Shonlein purpura(HSP) is a systemic small-vessel vasculitis that primarily affects the skin, gastrointestinal tract, joints, and kidneys. The nervous system may be involved, less commonly than other organs. When the central nervous system(CNS) was involved, headache, changes in mental status, seizures, and focal neurologic deficits have been reported. Hypertension, uremic encephalopathy, metabolic abnomalities, electrolyte abnormalities, or cerebral vasculitis were suggested...
Original Article
Safety and Efficacy of Early Treatment with Intravenous Immunoglobulin in Patients with Kawasaki Disease
Hyun Jin Kim, Hae Won Yom, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2003;46(10):1019-1023.   Published online October 15, 2003
Purpose : To determine the differences in clinical characteristics, blood chemistry and coronary artery complications between patients with Kawasaki disease who received intravenous immunoglobulin (IVIG) within the fourth day of illness and after the fifth day of illness. Methods : A retrospective chart review was conducted of all children with Kawasaki disease who were admitted to Ewha Mokdong Hospital between January...
Alteration of Biochemical Profiles after High-Dose Intravenous Immunoglobulin Administration in Kawasaki Disease
Ji-Won Lee, Kyung-Yil Lee
Clin Exp Pediatr. 2003;46(8):817-820.   Published online August 15, 2003
Purpose : Intravenous immunoglobulin(IVIG) has been used as an immunomodulatory treatment for several immune-mediated diseases. The early effect of high-dose IVIG on biochemical profiles including lipids and proteins was evaluated in patients with Kawasaki disease(KD). Methods : Twelve children with KD(nine boys) were treated with IVIG of 2 g/kg over 12 hours. Serial sera were collected from the patients four times...
Laboratory Values in Patients with Kawasaki Disease after Intravenous Immunoglobulin : Comparison of Patients with Coronary Artery Lesions to those without Coronary Artery Lesions
Min-Young Park, Kyung-Yil Lee, Ji-Whan Han, Hyung-Shin Lee, Ja-Hyun Hong, Kyung-Tai Whang
Clin Exp Pediatr. 2003;46(2):162-166.   Published online February 15, 2003
Purpose : We evaluated the effects of intravenous immunoglobulin(IVIG) on level of laboratory parameters examined serially according to the existence of coronary artery lesions in children with Kawasaki disease. Methods : Children with Kawasaki disease(n=63), treated with IVIG at a dose of 2.0 g/kg, were classified as a group with coronary artery lesions(CALs＋ group, n=9) or a group without coronary...
Changes in Mean Platelet Volume and Platelet Distribution Width after Therapy in Childhood Idiopathic Thrombocytopenic Purpura
Jong Tai Kim, Kyung Won Lee, Soon Nam Kim, Moon Kyu Kim
Clin Exp Pediatr. 2002;45(4):505-511.   Published online April 15, 2002
Purpose : Mean platelet volume(MPV) and platelet distribution width(PDW) are useful parameters in evaluating disorders of platelets. In cases with idiopathic thrombocytopenic purpura(ITP), they change as platelet count increases. In this study, we compared the values of MPV and PDW in ITP patients at diagnosis with those of normal children. We also studied whether the early changes in MPV may...
Case Report
A Case of the Use of Intravenous Immunoglobulin of Treatment for HyperIgE Syndrome
Yoon Ji Choi, Dong IL Lee, Hong Bae Kim
Clin Exp Pediatr. 2001;44(11):1301-1304.   Published online November 15, 2001
Hyper-IgE syndrome is a rare congenital immune deficiency disease characterized by severe eczema, recurrent infection of the sinopulmonary tract, cold subcutaneous abscess and high serum IgE levels. It is an autosomal dominant disease with incomplete penetrance. We examined the case of a 12 month old infant with hyperIgE syndrome since neonate. The diagnosis of hyper IgE syndrome was made because...
A Case of Aseptic Meningitis Following Administration of Intravenous Immunoglobulin in A Patient with Idiopathic Thrombocytopenic Purpura
Su Jin Kim, Ji Eun Kim, Hei Won Hwang, Ji Sun Mok, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim
Clin Exp Pediatr. 2001;44(7):823-826.   Published online July 15, 2001
Intravenous immunoglobulin(IVIG) has been widely used to treat idiopathic thrombocytopenic purpura in childhood. Aseptic meningitis has been reported as a rare complication of IVIG therapy. This report is on an 11 year-old boy with ITP who suffered from aseptic meningitis following the administration of IVIG. He was given 1 g/kg of IVIG for 2 days, and on the fourth day...
A Case of Acute Renal Failure Following Intravenous Immunoglobulin Therapy in a Child
Sung-Wook Park, Kyung-Yil Lee, Kyung-Yil Lee, Kye-Nam Yoon, Sang-Won Cha, Dong-Jun Lee, Ji-Whan Han, Kyung-Tai Whang
Clin Exp Pediatr. 2000;43(5):720-724.   Published online May 15, 2000
Intravenous immunoglobulin(IVIG) therapy is associated with a number of complications, including rare acute renal failure(ARF). Although the cause of IVIG-associated ARF is unknown, it may be related to the stabilizing agent used in IVIG preparations. ARF following IVIG infusion has not been previously described in children. We report a 4-year-old girl with Kawasaki disease who suffered from ARF following IVIG...
Original Article
Immunologic Alterations of Peripheral Mononuclear Cells by Intravenous Immunoglobulin in the Acute Stage of Kawasaki disease
Ji-Whan Han, Kyung-Yil Lee, Kyong-Su Lee
Clin Exp Pediatr. 1998;41(6):813-824.   Published online June 15, 1998
Purpose : High dose intravenous immunoglobulin(IVIG) therapy is effective in reducing the incidence of coronary artery aneurysm in Kawasaki disease(KD) patients, however, the precise mechanisms by which IVIG reverses the immune activation is unknown. Methods : The sera and peripheral mononuclear cells(PBMCs) were obtained from 10 KD patients in the acute stage(24 hrs before) and 24 hrs after one dose of IVIG(2g/kg) treatment. We measured...
The Study of Transplacental Transfer of Immunoglobulin G in Premature Infants
Sung Soo Moon, Yoon Ki Kang, Soo Chul Cho, Jung Soo Kim
Clin Exp Pediatr. 1998;41(6):747-753.   Published online June 15, 1998
Purpose : Premature infants have low serum immunoglobulin G(IgG) levels because IgG is transplacentally acquired, primarily after 32-34 weeks of gestational age. We studied the transplacental transfer of serum IgG in preterm infants. Methods : The IgG levels in the sera were measured by radial immunodiffusion method(Behring nephelometer, Germany). Results : There was a significant difference between IgG concentration and gestational age; the IgG concentration increased...
Clinical Trial of 2g/kg/day of Intravenous Immunoglobulin Single Dose as Compared with 400mg/kg/day of Intravenous Immunoglobulin for 5days in Kawasaki Disease
Seok Hee Oh, Heung Tag Kim, Hae Jin Chech, Kyuchul Choeh
Clin Exp Pediatr. 1997;40(11):1582-1587.   Published online November 15, 1997
Purpose : Since the effect of intravenous immunoglobulin (IVIG) therapy in Kawasaki disease was reported in 1984, the combined therapy of IVIG & oral aspirin has been popular. In early period, the protocol of 400mg/kg/day for 3-5 days of IVIG had been used, but rescently, the protocol of 2g/kg/day single dose has been preferred. So authers performed a clinical study to compare th efficacies...
The Change of Anti-HBs Titer after Injection of HBIG and HBV in Newborn Delivered from HBsAg Carrier Mothers
Qoae Suk Roh, Jin Young Jung
Clin Exp Pediatr. 1997;40(8):1141-1148.   Published online August 15, 1997
Purpose : We studied prevention effects of vertical transmission of Hepatitis B with follow-up, through the change of Anti-HBs titers during 9 months after injection of Hepatitis B immunoglobulin(HBIG) and Hepatitis B vaccine(HBV) at birth in newborn delivered from Hepatitis antigen carrier mothers. Methods : This study was performed on newborn delivered from HBsAg carrier mothers at Hae Sung Hospital from Feb. 1995 to May...
Case Report
A Case of Nezelof's Syndrome
Hyeon Tae Kim, Nok Hong Kim, Eun Yeong Seol, Ki Hyun Chun, Kung Ho Lee, Mun Ki Cho, Kung Ran Choi
Clin Exp Pediatr. 1996;39(11):1620-1626.   Published online November 15, 1996
Nezelof's syndrome(combined immunodeficiency with immunoglobulin) is a hereditary primary immunodeficiency characterized by recurrent chronic pulmonary infections, oral and cutaneous candidiasis, failure to thrive, chronic diarrhea, skin infection, urinary tract infection, gram-negative sepsis, severe progressive varicella infection, lymphopenia, diminished lymphoid tissue, abnormal structure of the thymus, and presence of normal or increased levels of one or more of the major immunoglobulin classes, but with impaired antibody...
Original Article
Immunologic Abnormalitiesin Kawasaki Diseaseand the Effect ofIntravenousImmunoglobulin
Joon Sung Lee, Bin Cho, Sung Hoon Cho
Clin Exp Pediatr. 1996;39(5):691-702.   Published online May 15, 1996
Purpose : It has been suggested that immunologic abnormalities play a role in the pathogenesis of vascular injury in Kawasaki disease and the immunologic abnormalities could be regulated by high-dose intravenous immunoglobulin(IVIG). We investigated the peripheral blood lymphocyte subsets, the serum levels of interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) and the effect of high-dose IVIG(400 mg/kg/day for 5 days) on these factors during acute stage of...
Effect of Intravenous Immunoglobulin(IVIG) on Renal Function in Very Low Birth Weight Infants
Hwa Young Jang, Haeng Mi Kim
Clin Exp Pediatr. 1996;39(4):475-481.   Published online April 15, 1996
Purpose : This study was conducted to evaluate the effect of IVIG infusion on renal function in VLBW infants. IVIG has been proved quite safe in neonates given prophylactic and therapeutic doses. But nephrotoxicity is not recognized as adverse in IVIG therapy, only several previous adult cases have been noted. Methods : For a total of ten VLBW infants who had...
Effect of IVIG Treatment on Renal Function in Neonates
So Yeon Kim, Haeng Mi Kim
Clin Exp Pediatr. 1994;37(10):1414-1419.   Published online October 15, 1994
This study was conducted to evaluate the effect of intraveneous immunoglobulin(IVIG) infusion on renal function in neonates. IVIG has provided quite safe in neonates given therapeutic doses. But nephrotoxicity is not a recognized adverse events of IVIG therapy, only several previous adult cases having been described. A total twenty five neonates suspected sepsis was randomely assigned to IVIG(n=12) or control(n=13) group. Neonates...
A Study on Serum Immunoglobulins and Complements in Newborn Infants by Gestational Weeks
Ji Eun Lee, Kyung Hyo Kim, Kyung Hee Kim
Clin Exp Pediatr. 1993;36(11):1555-1561.   Published online November 15, 1993
The author investigated serum immunoglobulin (IgG, IgA, and IgM) and complements (C3) of cord blood in 74 cases of normal fulterm infants and 50 cases of premature infants. Serum immunolglobulin and complement levels were measured by the single radial immunodiffusion method. The following results were obtained ; 1) The mean serum IgG levels of cord blood in 74 cases of the normal...
Intravenous Immunoglobulin for Prophylaxis of Neoneatal Sepsis in the Premature Infants
K.H. Hur, S.H. Kim, H.S. Kim, M.J. Chey, K.H. Kim, H.S. Lee
Clin Exp Pediatr. 1993;36(11):1534-1541.   Published online November 15, 1993
Newborn premature babies have low levels of transplacentally acquired maternal immunoglobulin which is mostly transferred after 32∼34weeks gestation, therefore they may have IgG deficiencies that incerase their susceptibillity to bacterial infection. We preformed this study to determine whether intravenous immunoglobulin (IVIG) therapy improves mortality or infection occurrence rate. From 1 october 1991 to 31 july 1992, 73premature newborn iffants with gestational age≤34weeks...
Changes of IgG Subclasses in the Sera of the Children with Kawasaki Disease
Seog Beom Cho, Sun Kyu Park, Pyoung Han Hwang, Jung Soo Kim, Sa Hyoung Choi
Clin Exp Pediatr. 1993;36(9):1197-1202.   Published online September 15, 1993
Kawasaki disease is an acute vasculitis of infancy and early childhood characterized by high fever, rash, mucositis, lymphadenopathy and coronary artery damage. The failure to indentify a causative organism using convetional culture and serological techniques, and the lack of response to antibiotics indicate that the disorder is probably not due to any known bacterial or viral pathogens. During...
A study on the immune reaction to the milk protein antigens in the postpartum mother, newborn baby, and children.
Soo chul Cho, Ju Hyung Kim, Hong Ro Lee, Jong San Lee, Pyoung Han Hwang, Jung Soo Kim
Clin Exp Pediatr. 1991;34(11):1547-1558.   Published online November 30, 1991
There is continuing interest in the isotype response of human serum antibodies reactive with dietary proteins. This study was performed to clarify the humoral immune responses against cow’s milk proteins, 分-lactoglobulin and a-lactalbumin. Milk protein specific IgG, IgA, IgM, and IgG subclasses were measured using ELISA in the blood of various groups of age. The results were as follows: 1) Milk protein specific immunoglobulins were higher...
A case of hyperimmunoglobulin E syndrome.
Myeong Cheol Shinn, Sung Dong Choi, Byung Gyu Suh, Jin Han Kang, Joon Sung Lee
Clin Exp Pediatr. 1991;34(2):292-298.   Published online February 28, 1991
The hyperimmunoglobulin E syndrome is a primary immunodeficiency disorder characterized by serious recurrent bacterial infections of the skin and respiratory system in early life, and markedly elevated serum IgE level. These recurrent infections are generally subcutaneous abscesses caused by Staphylococcus aureus. Also, additional characteristrics of this syndrome include coarse facial appearance, chronic pruritic dermatitis and eosinophilia. The baisic immunologic defect mechanism in hyperimmunoglobulin E syndrome is...
Changes of PPD-Specific Immunoglobulin in Pulmonary Tuberculosis After Treatment.
Ja Young Kim, Mun Hwan Lee, Pyoung Han Hwang, Chan Uhng Joo, Jung Soo Kim
Clin Exp Pediatr. 1990;33(12):1647-1655.   Published online December 31, 1990
The definite diagnosis and precise assessment of response to therapy is still a problem in childhood tuberculosis because these patients rarely produce sputum and if obtained it may be negative. For this reason, diagnosis rely largely on the clinical and X-ray examination, which have a low specificity and high proportion of false positive results. Recently immunologic diagnosis of tuberculosis using enzyme-linked immunosorbent assay (ELISA) was...
Changes of beta-lactoglobulin Specific Immunoglobulins According to the Age and the Onset of Cow's Milk Feeding.
Jong San Lee, Soo Young Cho, Pyoung Han Hwang, Soo Cheol Cho, Jung Soo Kim
Clin Exp Pediatr. 1990;33(12):1639-1646.   Published online December 31, 1990
It is not yet possible to explain in detail the pathogenesis of the diverse types of food allergy encountered clinically. This generalization applies to milk allergy in spite of the large number of studies reporting the immune responses to cow’s milk proteins, both in healthy subjects and in milk sensitive patients. This study was performed to define the changes of circulating immunoglobulins against milk protein...
Immunologic Changes in Bronchial Asthma on Immunotherapy.
Joon Sung Lee, Kyung Tai Whang, Sung Hoon Cho
Clin Exp Pediatr. 1990;33(9):1255-1261.   Published online September 30, 1990
The best treatment of allergic disease is to avoid exposure to known allergen. Immunotherapy has been attempted in IgE-mediated allergic patients who didn’t show any responses to pharmacologic therapy or couldn’t avoid allergen. There have been many enthusiastic claims for symptomatic relief of allergic disease by various forms of hyposensitization, first introduced by Noon and Freeman (1911) in the treatment of hay fever. The mechanism of...
An Experience of High Dose Intravenous Immunoglobulin Therapy in Refractory Evans Syndrome.
Hee Sup Kim, Won Sup Shin, Sang Il Lee, Sang Woo Kim
Clin Exp Pediatr. 1990;33(5):701-707.   Published online May 31, 1990
Evans syndrome, a combination of autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura, relapses freguently and is refractory to conventional treatment such as corticosteroid, immunosuppressive agents, splenectomy and plasma exchange. Recently Oda et al applied high dose immunoglobulin (400/kg/day for 4 days repeated 2 weeks later) to 5 month-old infant with refractory Evans syndrome, and was successful in maintaining remission for five years and nine...
Specific Antibody Response in House Dust Mite Asthmatics on Immunotherapy.
Won Sup Shin, Bub Sung Kim, Sang Il Lee
Clin Exp Pediatr. 1989;32(9):1282-1287.   Published online September 30, 1989
The immunotherapy has become a useful and effective method to treat allergic respiratory diseases. It is a logical assumption that immunotherapy produces symptom relief as a result of immunologically specific response. This study was performed to delineate the IgE, IgG and IgG4 responses to immunotherapy, and their relationships. We selected the six asthmatic children on immunotherapy with Dermatophagoides pteronyssinus (Dp). A set of samples from each...
Serum IgE Levels in Bronchiolitis Patients.
Seong Hee Choi, Keun Lee
Clin Exp Pediatr. 1989;32(6):749-755.   Published online June 30, 1989
Bronchiolitis is a virus.caused lower respiratory disease resulting from inflammatory obstruction of the small airways. The condition may develop to asthma anddifferential diagnosis is not clearcut between two diseases during infancy. Measurement of the serum IgE concentration has been used as an aid in the differential diagnosis. The purpose of this study is to compare the serum IgE levels between control groups and bronchiolitis patients,...