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Case Report
A Case of Congenital Solitary Liver Abscess
Sang Hee Kim, So Young Kim, You Jeong Kim, Hyun Hee Kim, Won Bae Lee, Kyung Tai Whang
Clin Exp Pediatr. 2002;45(11):1426-1429.   Published online November 15, 2002
Congenital solitary liver abscess in newborns is an extremely rare and serious disease. Only one case was reported in the literature. Most a liver abscesses have a postnatal origin. We encountered a premature infant who had a low. Apgar score and an elevated right diaphragm at birth. Pyogenic solitary liver abscess was diagnosed by ultrasound and computed tomography. Staphylococcus aureus...
Original Article
Serum Fatty Acid and Carnitine Levels in Obese Children with Fatty Livers
Jin Bum Lee, Jae Won Lee, Young Mi Hong
Clin Exp Pediatr. 2002;45(9):1083-1089.   Published online September 15, 2002
Purpose : The prevalence of obese children has recently increased. Obesity is known to be associated with complications such as hypertension, fatty liver, hyperlipidemia, and insulin resistance. L-carnitine is an essential cofactor for the transport of long chain fatty acids into mitochondria for β-oxidation. The purpose of this study is to measure serum free fatty acid and carnitine levels, and...
Megakaryocyte Colony Formation of Fetal Liver Cells
Byung O Kwon, Hye Young Ju, Chun Soo Kim, Dong Seok Jeon, Jong In Kim, Heung Sik Kim
Clin Exp Pediatr. 2002;45(2):247-255.   Published online February 15, 2002
Purpose : This study was undertaken to obtain basic data about the megakaryocyte colony formation of fetal liver cells by using immunocytochemical staining and ex vivo culture with growth factors. Methods : The mononuclear cells were isolated from fetal liver and bone marrow with idiopathic thrombocytopenic purpura(ITP) and pancytopenia. These mononuclear cells were cultured in MegaCultTM-C(Stem Cell Tech, Canada) media in...
Risk Factors for Fatty Liver in Obese Children
Ki Won Park, Jong Eun Lee, Kyung Ha Ryu, Kyung Hyo Kim, Young Mi Hong, Gyung Hee Kim, Keun Lee, Jeong Hyun Yoo
Clin Exp Pediatr. 2001;44(6):669-676.   Published online June 15, 2001
Purpose : The incidence of obese patients has increased recently in Korea. Obesity is associated with hypertension, hyperlipidemia, insulin resistance, and fatty liver. Since recent investigators have revealed that not only fat accumulation but also fibrosis and nonspecific hepatitis can be found in the livers of obese children, fatty liver is currently considered as an important complication. The purpose of...
Effect of Liver Transplantation in Children with Fulminant Hepatitis
Young Mee Seo, Bo Hwa Choi, Kyung Mo Kim, Kwang Min Park, Young Joo Lee, Sung Gyu Lee
Clin Exp Pediatr. 2000;43(4):535-542.   Published online April 15, 2000
Purpose : Liver transplantation(LT) is regarded as an important management option for fulminant hepatitis(FH), which is associated with considerable mortality under conservative management. The aim of this study was to evaluate the outcome of children with FH according to management. Methods : We reviewed medical records of patients presented with FH from January 1994 until April 1999. The children were...
Case Report
A Case of Ornithine Transcarbamylase Deficiency Successfully Treated with Protein Restriction and Living Related Liver Transplantation
Bong Seong Kim, Kyung Mo Kim, Han-Wook Yoo, Sung Gyu Lee
Clin Exp Pediatr. 1999;42(6):868-873.   Published online June 15, 1999
Ornithine transcarbamylase deficiency(OTCD), the most common inborn error of the urea cycle, is inherited in X-linked manner. In affected hemizygote males, OTCD manifests hyperammonemic coma that often leads to death during the newborn period. Our patient was at high risk for inborn error of urea cycle metabolism, since his two elder brothers died a few days after birth due to...
Original Article
Living Related Donor Liver Transplantation in Children : Indication and Clinical Outcome
Kyung Mo Kim, Sung gyu Lee, Young Joo Lee, Kwang Min Park, Seong Chul Kim, Hoon Bae Chun, Eun Sil Yoo, Sang Hoon Han, Kyung Suk Ko, Mon Gyu Lee, Kyu Taek Choi, Jae Kon Ko, Hyung Nam Moon
Clin Exp Pediatr. 1998;41(5):622-632.   Published online May 15, 1998
The Efficacy of Routine Liver Function Test Follow Up in Epileptic Children
Dae Hun Pee, Hyung Joo Sohn, Young Kyoo Shin, Baik Lin Eun, Sang Hee Park, Soon Kyum Kim
Clin Exp Pediatr. 1997;40(5):660-671.   Published online May 15, 1997
Purpose : Routine liver function test follow up is done in epileptic children receiving antiepileptic drugs to prevent hepatotoxicity induced by these drugs. But rarely seen are the abnormalities of liver function test, and seldomly are these abnormalities accompanied by the clinical manifestation. This study is carried out to assess the efficacy of routine liver function test follow up in...
The Diagnostic Value of Liver Biopsy in Children with Fever of Unknown Origin and Hepatosplenomegaly
Sue Mee Park, Yeon Ho Choi, Jong Jae Kim, Hoan Jong Lee, Jeong Kee Seo
Clin Exp Pediatr. 1996;39(11):1544-1555.   Published online November 15, 1996
Purpose : Although many strides have been made in the radiological and laboratory diagnosis, the liver biopsy is still considered an important tool for the diagnosis of liver disease. We report our experience that histologic investigation of the liver was essential searching for the etiologic diagnosis in eight children with fever of unknowm origin and hepatosplenomegaly, who's diagnosis were not documented by other diagnostic...
Predictor of Fatty Liver in Obese Children
Hyunmi Kim, Young Mi Hong, Gyoung-Hee Kim, Jung Hyun Yu
Clin Exp Pediatr. 1996;39(6):803-810.   Published online June 15, 1996
Purpose : The childhood obesity is currently increasing. The childhood obesity is difficult to treat and the response of treatment is transitory because it is caused by the hyperplasia of fatcells. The complications of obesity are hyperlipidemia, hypertension, diabetes, artherosclerotic coronary arterial disease and fatty liver. Therefore the early diagnosis and prevention of obesity from childhood is very important. This study...
Case Report
A Case of Chronic Granulomatous Disease Associated with Pyogenic Liver Abscess
S.K. Lee, J.H. Kim, S.Y. Kim, E.T. Oh, H.J. Kang, K.S. Kim
Clin Exp Pediatr. 1996;39(4):585-590.   Published online April 15, 1996
We have experienced a case of chronic granulomatous disease associated with pyogenic liver abscess in 10 years old male Chronic granulomatous disease(CGD) is a hereditary disorder of neutrophil with defective killing and digesting of ingested catalase-positive bacteria or fungi in spite of normal phagocytosis. It was diagnosed by clinical finding and laboratory examination including NBT test. Pyogenic liver abscess in old...
Original Article
A Clinical Study on the Liver Cirrhosis in Children: Review of 40 Cases
Je Woo Kim, Ki Sup Chung, Chan Il Park
Clin Exp Pediatr. 1995;38(11):1506-1514.   Published online November 15, 1995
Purpose : Liver cirrhosis is relatively uncommon disease in childhood, but the overall prevalence rate and etiology of the liver cirrhosis in children were uncertain in Korea. This clinical study was undertaken to help pediatricians manage the patients properly by investigating the etiology, clinical findings and the outcome on 40 pediatric patients with liver cirrhosis. Methods : This study was conducted...
Prospective, Controlled Trial with Dipheny1-dimethy1-dicarboxylate in Children with Chronic Liver Diseses : The Effect on Lowering Serum Aminotransferase Levels
Ji Eun Wunon, Sang Gil An, Ki Moon Cha, Yong Min Chung, Hee Sup Kim, Hann Tchah, Ho Jin Park
Clin Exp Pediatr. 1995;38(10):1378-1383.   Published online October 15, 1995
Purpose : The prospective cotrolled study was performed to identify the effect of the dipheny1-dimethy1-dicarboxylate(PMC) on lowering serum transaminases in children with chronic liver diseases. Methods : The twenty patients were paticipated in this study who were followed up in the Department of Pediatrics of the Seoul Red Cross Hospital because of the elevated levels of serum alaine aminotransferase(ALT) and aspartate...
Clinical study on metabolic liver diseases in infancy and childhood.
Jeong Lim Kim, Ki Sup Chung
Clin Exp Pediatr. 1991;34(11):1477-1493.   Published online November 30, 1991
The liver plays a central role in synthetic, degradative, and regulatory pathways involving the metabolism of carbohydrates, protein, lipid, mineral, and vitamins. There are many metabolic abnormalities or specific enzyme deficiencies that affect the liver. The clinical manifestations of metabolic diseases of the liver mimic infections, intoxications, and other systemic diseases. The comprehension of the pathogenesis on the inborn metabolic errors and early...
The incidence of complications in severely obese children.
Dong Hwan Lee, Chong Guk Lee, Chul Lee, Yong Seung Hwang, Sung Ho Cha, Yong Choi
Clin Exp Pediatr. 1991;34(4):445-453.   Published online April 30, 1991
The measurement of body weight, height and blood pressure, urine sugar, oral glucose tolerance test, S-GOT, S-GPT, cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol tests were made in 324 severely obese elementary, middle and high school students (218 boys and 106 girls) to know the incidence of complication in these children. . The results were as follow: 1) S-GOT or S-GPT were increased abnormally in 38.3% and fatty livers were...
A Case of Pancreatoblastoma with Metastasis of the Liver.
Dae Sung Oh, Yong Won Paik, Jae Sun Park, Kyung Hyun Choi, Man Ha Huh
Clin Exp Pediatr. 1990;33(5):684-689.   Published online May 31, 1990
We experenced a case of pancreatoblastoma in a 6 years old Korean male who was admmited to the pediatric department because of an abdominal mass and pathologically diagnosed following surgical removal. Microscopically, the resected mass was composed of small sized tumor cells arranged in glandular or acini structure with multifoci of squamoid corpuscle. Extensive hemorrhagic necrosis was another feature. Ultrastructucturally, two types of cells, dark...
Liver Function Test in Congestive Heart Failure in Children.
Chan Yung Kim, Man Chul Ha
Clin Exp Pediatr. 1988;31(1):48-57.   Published online January 31, 1988
Clinical study was carried out on 149 congestive heart failure(CHF) cases of 873 heart disease patients admitted to the Department of Pediatics, Pusan National University Hospital from January 1980 to June 1987 and performed various diagnostic evaluations, especially liver function tests. The results obtained were as follows. 1) The congenital (CHD) and acquired (AHD) cause of heart disease were each 75.9% and 19.0% and the rest,...
A Case of Congenital Hepatic Fibrosis with Hypersplenism.
Hye Suk Hong, Yang Won Lee, Keon su Rhee, Young Hun Chung
Clin Exp Pediatr. 1987;30(12):1456-1460.   Published online December 31, 1987
Congenital hepatic fibrosis is a relatively rare disease of liver in children and young adults, manifesting a heredofamilial tendency, that is characterized by hepatosplenomegaly, protal hypertension and frequent renal involvement. A generalized portal and interlobular fibrosis of liver are characteristic finding on microscopy, with relative preservation of hepatocyte and liver function. Recently, we have experienced a case of congenital hepatic fibrosis in a...
An Analysis of Incidence Requiring Resuscitation in Full-Term Cesarean Delivered Infants.
Ewi Seong Seo, Cheol Soo Dan, Woo Yeong Chung, Soon Yong Lee, Goo Hwa Je
Clin Exp Pediatr. 1987;30(7):722-726.   Published online July 31, 1987
An analysis of incidence requiring resuscitation in relation to the indication of cesarean section in full-term deliveries were carried out retrospectively during 24 months from January 1984 to December 1985. The results obtained were as follows. 1) The overall incidence of cesarean delivery was 17.2% (397 cases out of 2,308 total deliveries) and the rate of full-term was 77.6% of total cesarean deliveries. 2) Among full-term cesarean delivered...
A Study of Liver Span in Normal Newborn Infant.
Byung Ryul Choi, Chun Dong Kim, Hyun Mo Koo, Yong Hoon Park, Han Ku Moon, Jin Gon Jun, Jeong Ok Hah
Clin Exp Pediatr. 1985;28(6):534-537.   Published online June 30, 1985
Liver size was measured in 100 healthy newborn infants of gestational ages 38 to 42 weeks who were born at the Yeungnam University Hospital. The liver span was determined by measuring the distance between the percussed upper and palpated lower liver borders along the mid clavicular line (P-P method). The mean liver span was 4.6±0.3 cm. Liver span measured by...
Case Report
A Case of Pyogenic Liver Abscess with Fever of Unknown origin.
Soo Baeck Lee, Kwang Soo Hwang, Kyung Sook Cho, Doo Sung Moon
Clin Exp Pediatr. 1983;26(11):1145-1148.   Published online November 30, 1983
Pyogenic liver abscess is a rare disease in normal children. Our case was 7 year old boy who had suffered from spiking high fever and upper abdominal discomfortness for 14 days. Liver function tests were normal and blood cultures were negative. An accurate preoperative diagnosis was pyogenic liver abscess, which was diagnosed, by ultrasound and scintigram. Final diagnosis was solitary pyogenic liver abscess at...
A Case of Pyogenic Liver Abscess.
Jeong Bok Lee, Dong Hwan Cho, Sook Kyeung Jung, Won Jae Park, Jin Kook Kang
Clin Exp Pediatr. 1983;26(11):1111-1114.   Published online November 30, 1983
We have experienced a case of pyogenic liver abscess with omphalitis in 21 days old :female. We diagnosed liver abscess with liver scanning and ultrasonography,. confirmed by exploratory laparotomy and tissue biopsy. She was treated with parenteral antibiotics. We have presented a rare case and reviewed the literature.
A Case of Congenital Hypoplastic Anemia.
Young Jong Woo, Jae Sook Ma, Tai Ju Hwang
Clin Exp Pediatr. 1983;26(2):188-192.   Published online February 28, 1983
Authors have observed a case of congenital hypoplastic anemia in 18 months old male patient who was diagnosed through the bone marrow aspiration. The liver was enlarged and the biopsy specimen disclosed iron deposition in the hepatocyte, which was thought to be resulted from multiple blood transfusion and administration of iron preparation. A brief review of related literature was made.
Original Article
A Study of the Liver Biopsies in Infancy and Childhood.
Mea Young Chung, Ki Sup Chung, Chan Il Park, Yoo Bock Lee
Clin Exp Pediatr. 1982;25(7):656-668.   Published online July 31, 1982
To investigate the liver diseases affecting infancy and Childhood and to make a clinicopathologic correlation, a total of 105 liver biopsies were examined and following results were obtained. 1. Of the 105 liver biopsies, 94 cases were available for the study, and the male to female ratio of liver biopsies in infancy and childhood was 1.8 : 1. 2. Of...
Case Report
A Case of Polycystic Kidney Associated with Pulmonary Hypoplasin in a Newborn Neonate.
Seong Ky Chung, Yoon Bae Lim, Ky Yang Ryoo, Seong Hoe Park
Clin Exp Pediatr. 1982;25(4):393-398.   Published online April 30, 1982
Polycstic kidney was rare problem of pediatric disease category. We have experienced one case of polycstic kidney(Potter type I) with pulmonary hypoplasia who born after 35 weeks of gestation to a 34 year-old mother. The clinical course of this infant was characterized by respiratory difficulty with apnea, cyanosis and marked abdominal distension. Chest X-Ray film showed no airation in the...
Original Article
A Case-Control Study on the Factors Influencing Neonatal Hyperbilirubinemia.
Kwang Ho Meng, Won Chul Lee, Kyung Tai Whang
Clin Exp Pediatr. 1982;25(2):136-140.   Published online February 28, 1982
Neonatal Hyperbilirubinemia is increasing in frequency and there have been suggestions that this may be due to some change in factors involved in delivery. In this study, among numerous hypothesized factors, maternal age, gestational age, birth weight, birth order, and methods of delivery were tested if there were statistical associations between these factors and occurance of neonatal hyperbilirubinemia. For the...
Case Report
A Case of Chronic Active Hepatitis.
H J Park, H K Park, H J Chun, M J Shin, S C Kang
Clin Exp Pediatr. 1981;24(10):991-996.   Published online October 15, 1981
Chronic active hepatitis (CAH) is defined as ongoing inflammation within the liver sustained beyond the expected time of resolution. The etiology of CAH is not completely understood, but hepatitis B infection, drugs such as oxyphenisatin, isoniazid, and alpha-methyldopa, and altered immunity are considered. The most common findings are jaundice, hepatosplenomegaly, elevated serum transaminase activities, hypergammaglobulinemia, and positive "autoimmune" serologic tests,...
Tuberculous Abscess and Empyema of the Liver.
Ran Nam Gung, Kwan Sub Chung, Ki Sup Chung, Duk Jin Yun
Clin Exp Pediatr. 1981;24(7):690-695.   Published online July 15, 1981
We have experienced a case of tuberculous abscess of the liver with empyema in a 12 years old boy. He was admitted with the chief complaints of pain and mass in the right upper abdomen of about 1 month duration and intermittent mild fever for 15 days. On examination, liver was palpable 5 cm below the right costal margin, and...
Original Article
Percutaneous Needle Liver Biopsy in Infancy and Childhood.
Ki Sup Chung, Young Mo Sohn, Duk Jin Yun, Chan Il Park
Clin Exp Pediatr. 1981;24(7):609-619.   Published online July 15, 1981
Thirty percutaneous liver biopsy and one liver necropsy were reviewed in Severance Hospital, Yonsei University from June 1979 to September 1980. This procedure is the safe and accurate means of diagnosing and studying liver diseases in the pediatric patients especially persistent conjugated hyperbilirubinemia, chronic liver disease, and some rare diseases (eg. Histiocytosis-X, Storage disease disease, Gilbert syndrome), The significance of...
Case Report
A Case of Congenital Hepatic Fibrosis.
Son Moon Shin, Sang Il Lee, Joong Gon Kim, Hyo Seop Ahn, Hyung Ro Moon, Kwang Wook Ko, Je Geun Chi
Clin Exp Pediatr. 1981;24(6):577-583.   Published online June 15, 1981
Congenital hepatic fibrosis is a relatively rare liver disease in children and young adults,that is characterized by stony hard hepatomegaly and portal hypertension with relative preservation of liver function and underlying architecture. Since this Condition was first delineated by Kerr et al in 1961, approximately over 150 cases have been reported in the literature. However, congenital hepatic fibrosis was not...