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Original Article
Changes of Neutrophil Count in Peripheral Blood of the Neonate with Periventricular Leukomalacia
Hwan Seok Lee, Kyung Pil Park, Heng Mi Kim
Clin Exp Pediatr. 2003;46(10):966-971.   Published online October 15, 2003
Purpose : It is now well established that infection and inflammation play an important role in the pathogenesis of ischemic brain damage. The loss of neutrophils from systemic circulation is an associated finding in injury mediated by granulocyte. Periventricular leukomalacia(PVL) caused by ischemia is the principal form of brain injury in premature infants. This study was conducted to evaluate whether...
Total Parenteral Nutrition-associated Cholestasis in Premature Infants
Kyung Pil Park, Se Young Kim, Heng Mi Kim
Clin Exp Pediatr. 2003;46(1):17-23.   Published online January 15, 2003
Purpose : Cholestasis is a major complication in prolonged use of TPN, especially in the neonatal period, but there are few long-term reviews examining the clinical course in premature infants. Thus, in this study, we reviewed premature infants with TPN-associated cholestasis(TPNAC) to determine the incidence, clinical courses and possible risk factors. Methods : Retrospective review of 66 premature infants less than...
Usefulness of Serum Prealbumin Concentration as a Marker for Nutritional Adequacy in Premature Infants
Soo Jin Lee, Eun Ae Park, Jeong Wan Seo
Clin Exp Pediatr. 2001;44(8):867-874.   Published online August 15, 2001
Purpose : Serum prealbumin concentration has been proposed as a useful nutritional marker that responds rapidly and sensitively to calory and protein intake. But the reports of prealbumin in premature infants are not sufficient and variable. The purpose of this study was to evaluate the usefulness of serum prealbumin concentration as a marker for nutritional adequacy in premature infants. Methods...
Case Report
A Case of Congenital Chylothorax in a Premature Infant
Su Kyeong Oh, Young Hye Jeong, Youn Jee Choi, Soon Ok Byun, Ji Sub Oh
Clin Exp Pediatr. 2001;44(4):460-463.   Published online April 15, 2001
We experienced a case of isolated fetal pleural effusion diagnosed by antenatal ultrasonogram in the 33th week of gestational age. Chest PA at birth showed massive pleural effusion in both lungs. The serous pleural fluid changed to a milky nature after feeding so we diagnosed it as congenital chylothorax. The infant was managed by chest tube drainage, NPO & TPN...
Original Article
A Comparative Study of the Effects of Intravenous Indomethacin and Oral Mefenamic Acid in the Treatment of Premature Infants with Patent Ductus Arteriosus
Hae Jung Park, Yoon Suk Jung, Nam Soo Kim, Chang Ryul Kim, Hyuk Kim, Soo Jee Moon
Clin Exp Pediatr. 2001;44(1):32-39.   Published online January 15, 2001
Purpose : For the management of patent ductus arteriosus(PDA) in premature infants, fluid restriction, correction of anemia, mechanical ventilation, diuretics, and surgery have been used, and the closure rate of PDA has improved significantly since the introduction of indomethacin and mefenamic acid as pharmacologic treatments of PDA. We studied to evaluate and compare the therapeutic effects of indomethacin and mefenamic...
Doppler Echocardiographic Assessment of the Changes in Pulmonary Arterial Pressure in Preterm Infants with Respiratory Distress Syndrome
Sejung Sohn, Eun Ae Park
Clin Exp Pediatr. 1999;42(6):790-799.   Published online June 15, 1999
Purpose : The ratio of time to peak velocity(AT) and right ventricular ejection time(ET) as measured from the pulmonary artery Doppler waveform showed a close inverse correlation with pulmonary arterial pressure. The purpose of this study was to see the pattern of change in pulmonary arterial pressure assessed by AT/ET in preterm infants with respiratory distress syndrome (RDS). Methods : The...
Thyroid Hormone Concentrations in Preterm Infants
Sung Keun Moon, Jeong Nyun Kim, Mi Jung Park, Myung Jae Choi, Chrul Young Chung
Clin Exp Pediatr. 1998;41(10):1324-1328.   Published online October 15, 1998
Purpose : To establish reference ranges for thyroid hormone concentrations in premature infants, we measured T4 and thyroid stimulating hormone(TSH) concentrations and analyzed the relation to gestational age and birth weight. Methods : Serum T4 and TSH concentrations were measured by radioimmunoassay for 391 premature infants born in Sanggye Paik Hospital for two years and eight months. Results : Gestational age of...
The Study of Transplacental Transfer of Immunoglobulin G in Premature Infants
Sung Soo Moon, Yoon Ki Kang, Soo Chul Cho, Jung Soo Kim
Clin Exp Pediatr. 1998;41(6):747-753.   Published online June 15, 1998
Purpose : Premature infants have low serum immunoglobulin G(IgG) levels because IgG is transplacentally acquired, primarily after 32-34 weeks of gestational age. We studied the transplacental transfer of serum IgG in preterm infants. Methods : The IgG levels in the sera were measured by radial immunodiffusion method(Behring nephelometer, Germany). Results : There was a significant difference between IgG concentration and gestational age; the IgG concentration increased...
Effects of Patent Ductus Arteriosus on Right Ventricle in Premature Infants : by M-mode and Doppler Echocardiography
Eun Jeung Kim, Eun Sil Lee, Young Hwan Lee, Son Moon Shin, Jeong Ok Hah
Clin Exp Pediatr. 1998;41(6):734-740.   Published online June 15, 1998
Purpose : Patent ductus arteriosus, derived left to right shunt flows, elevate the pulmonary artery pressure in infants and children and may alter right ventricular afterload thereby right ventricular function. Therefore, we examined the effects of patent ductus arteriosus on the right ventricular systolic time interval in premature infants by non-invasive Doppler echocardiography. Methods : Tweleve premature infants with patent ductus arteriosus were studied...
A Survey on the Attitudes toward Premature Infants
Oh Hyuk Kwon, Son Moon Shin
Clin Exp Pediatr. 1998;41(3):307-314.   Published online March 15, 1998
Purpose : We studied the attitudes of general population and medical personnels toward premature infants to establish basic data about prematurity. Methods : Ten students from Yeungnam University College of Medicine conducted field surveys on the general population at residential and commercial districts, and on medical personnels at private local clinics and hospitals in Taegu with a prepared questionaire from July...
Case Report
A Case of Genital Prolapse in Premature Baby
Woong Kyu Choi, Seung Cheol Lee, Yong Won Park, Chong Guk Lee, Sang Woo Kim
Clin Exp Pediatr. 1998;41(2):281-284.   Published online February 15, 1998
Neonatal genital prolapse is very rare and is usually associated with meningomyelocele or other anomalies of the central nervous system. Synonyms of genital prolapse are sacropubic hernia, pelvic relaxation, and pelvic organ prolapse. There are two types of genital prolapse including vaginal prolapse and uterovaginal prolapse. We experienced a case of uterovaginal prolapse in a 30 day-old premature infant, which...
A Case of Herpes Zoster in Premature Infant
Kug Hwan Kim, Young Il Ro, Eun Seok Yang, Kyung Rae Moon, Sang Kee Park, Byung Su Jung
Clin Exp Pediatr. 1997;40(8):1169-1172.   Published online August 15, 1997
Herpes zoster, an inflammatory human disease caused by varicella zoster virus, is characterized by papulovesicular lesions along the distribution of a sensory nerve. We experienced a herpes zoster in 23 day old premature infant. The papules were distributed on his skin corresponding to the dermatomes innervated by the left Th3-Th4. The diagnosis of herpes zoster was made with dermatomal distribution of typical skin lesions, pathologic...
Two Cases of Systemic Candidiasis in Premature Infants
Dae Kyun Kim, Woo Chul Suh, Eun Gyeoung Jung, Eun Seok Yang, Sang-Kee Park
Clin Exp Pediatr. 1995;38(11):1558-1564.   Published online November 15, 1995
Reports of systemic candidiasis in neonates have been noted recently with its major advances in neonatal care permitting the frequent survival of low birth weight infant. Factors influencing the development of systemic candidiasis include prematurity, very low birth weight, the presence of intravascular catheter, the use of hyperalimentation, prolonged broad spectrum antimicrobial therapy and prolonged endotracheal intubation. We experienced two cases...
Original Article
Effect of Prophylactic Treatment of High Doses Recombinant Human Erythropoietin on Anemia in Premature Infants
Soon Seong Park, Seong Ho Hong, Hye Lime Jung, Dong Hyeok Keum
Clin Exp Pediatr. 1995;38(10):1384-1393.   Published online October 15, 1995
Purpose : This study was conducted to determine whether prophylatic treatment with recombinant human erythropoietin(rHuEPO) could prevent anemia and reduce the need for blood transfusion in premature infants. Methods : This study was conducted from May, 1992 to July 1994. We randomly assigned 24 premature infants with gestational age less than 34 weeks and birth weight less than 2.0kg. After having...
Case Report
Transfusion-Acquired Cytomegalovirus Infections in Two Premature Infants
Dong Wook Kim, Kyung Un No, Mi Jung Kim, Soon Mee Park, Hee Sup Kim, Young Pyo Chang, Hoan Jong Lee, Jung-Hwan Choi, Chong Ku Yun, Je Geun Chi
Clin Exp Pediatr. 1992;35(8):1141-1147.   Published online August 15, 1992
Transfusion-acquired perinatal cytomegalovirus (CMV) infection can cause significant morbidity and mortality, particularly in premature infants with a birth wight of less than 1,500 gm. This recognizable syndrome consisted of deterioration of respiratory function, hepatosplenogaly, unusual gray pallor with disturbing septic appearance, lymphocytosis, thrombocytopenia and hemolytic anemia. We experienced transfusion-acquired CMV infections in 2 premature infants with a birth weight of...
Original Article
Indomethacin therapy in premature infants with patent ductus arteriosus.
Dug Ha Kim, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1991;34(10):1381-1390.   Published online October 31, 1991
Patent ductus arteriosus (PDA) is a common disease that occurred in 20 〜 40 percent of premature infants. The incidence of PDA is inversely related to the gestational age and birth weight. Hemodynamically significant PDA increases the morbidity and mortality of premature infants. So, the management of PDA is one of the major problems in neonatal intensive care unit. Based on experimental animal studies,...
A case of neonatal systemic candidiasis.
Eun Ae Park, Gyoung Hee Kim
Clin Exp Pediatr. 1991;34(9):1286-1293.   Published online September 30, 1991
Systemic infection with Candida albicans in very premature infants is frequently fatal or associated with significant morbidity in survivors. Several common practices in newborn intensive care units, such as insertion of indwelling catheters, provision of parenteral nutrition, and prolonged administra- tion of broad-spectrum antibiotics or aminophylline, are associated with an increased risk of systemic disease. We have experienced a case of systemic candidiasis in 1/365...
Changein Regional Cerebral Blood Flow Velocity in Premature Infant.
Young Kyoo Shin, Chang Sung Son, Joo Won Lee, Young Chang Tockgo
Clin Exp Pediatr. 1990;33(10):1333-1340.   Published online October 31, 1990
In order to estimate the influence of systemic hemodynamic change in cerebral blood flow before and after closure of ductus arteriosus in premature mewborn infants, blood flow velocities of internal carotid artery (ICA), anterior cerebral artery (ACA) and middle cerebral artery (MCA) were measured in 17 premature newborn infants by pulsed Doppler ultrasonography. The data was compared with those of normal full-term infants by...
Exogenous Surfactant Replacement Therapy of Hyaline Membrane Disease: A controlled clinical trial.
Ran Namgung, Chul Lee, Kook In Park, Dong Gwan Han
Clin Exp Pediatr. 1990;33(1):22-34.   Published online January 31, 1990
We conducted a clinical controlled trial of exogenous surfactant replacement therapy in premature infants with hyaline membrane disease at the neonatal intensive care unit of Yonsei University Medical Center form Nov. 1987 to May 1988. Sixteen premature infants with severe HMD were randomly assigned to control group or surfactant-treated group. Eight infants (mean gestational age 29.9±2.8 week, mean birth weight 1, 425±308.9 gm) were given...
Blood Glucose Values in Healthy Premature Infants.
Heung Kyu Kim, Chul Seung Son, Eun Hee Cho
Clin Exp Pediatr. 1984;27(4):319-325.   Published online April 30, 1984
Serial blood glucose values were measured over the first twenty-four hours of life on 202 healthy permature infants. Whose weights were less than 2,300 grams. The 76 infants who were evaluated over a period of four weeks divided into two groups; 22 premature infants weighing less than 1,700 grams at birth, and 54 premature infants weighing over 1,700 grams. Eight...
Hyperglycemia in Stressed Premature Infants.
Heung Kyu Kim, Kyung Ho Kim
Clin Exp Pediatr. 1983;26(2):124-129.   Published online February 28, 1983
The blood glucose response to a constant glucose infusion were measured in 62 premature infants weighing 1,000 to 2,200 gm. The study includes 32 stressed premature infants who had respiratory distress, Necrotizing enterocolitis, premature rupture of membranes, sepsis and 30 control premature infants. During the first three hours of life, the glucose values were similar in both stressed and the control groups. During the four...
Result of a Mixture with Vegimil A(50%) and a known Local Infant Formular (50%) to Premature Infants.
Keun Soo Lee, Soo Jee Moon, Gwi Jong Choi, Sang Yoon Lee, Kyu Youp Kim, Kee Young Youn, Jin Woo Hahn
Clin Exp Pediatr. 1983;26(1):1-7.   Published online January 31, 1983
A prospective observation for growth (by weight) of 100 premature infants (some low birthweight infants were included) were conducted at the premature baby ward of Hanyang University Hospital during the one year period from May, 1981 to April, 1982. 100 subjects of the observation were devided in to 2 groups (A and B). Group A was consisted of 50 premature...
Platelet Counts in Healthy Premature Infants.
Heung Kyu Kim, You Nam Kim
Clin Exp Pediatr. 1981;24(9):805-811.   Published online September 15, 1981
Serial platelet counts performed at four day intervals on forty two healthy premature infants whose birth weights were less than 2200 grams. The forty two infants were divided into two groups: twelve premature infants weighing less than 1700 grams, and thirty prematures infants weighing over 1700 grams at birth. We evaluated the length of time for the platetet counts of...
Eosinophilia in Premature Infant's.
Ho Jin Lee, Jung Woo Suk, Don Hee Ahn, Keun Chan Sohn
Clin Exp Pediatr. 1981;24(3):216-220.   Published online March 15, 1981
e A study of eosinophilia in premature infants was performed to determine if eosinophilia could be an index of weight gain in premature infants. Thirteen premature infants born at 30-37 week's gestation and cared at N.M.C. from Jan, *80 to Aug. ’80 were included in this study. The results were as follows: 1. Eosinophilia (>700/mm3) was documented in 69.2% (9/13). 2.There...