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Original Article
Effect of Glucocorticoid-Induced Hyperglycemia on Preventing Hypoxic-Ischemic Brain Damage by Dexamethasone in Neonatal Rat
Kook In Park, Tae Seung Kim, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1994;37(8):1035-1047.   Published online August 15, 1994
Purpose : We evaluated the protective effect of dexamethasone (DX) administration on brain damage produced in a perinatal model of cerebral hypoxia-ischemia in the rat. Since hyperglycemia has been shown to reduce hypoxic-ischemic brain injury (HI) in immature rat, we investigated the role of glucocorticoid-induced hyperglycemia in the neuroprotective mechanism of DX. Methods : Hypoxic-ischemic brain injury in 7-day-old rats was...
Intraventricular Hemorrhage in Full-Term Neonate
Myoung Bae Jeon, Kook In Park, Choon Sik Yoon, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1994;37(6):776-785.   Published online June 15, 1994
Intraventricular hemorrhage is a common hemorrhagic cerebral disorder in premature, but occurs much less frequently in the full-term newborn. In order to obtain documentation of clinical and ultrasonographic characteristics of intraventricular hemorrhage in full-term, we performed cerebral ultrasonography on 602 newborn infants who had been admitted to neonatal intensive care unit at the Deppartment of Pediatrics, Yonsei University College of...
Case Report
A Case of Brain Damage in Surviving Monozygotic Twin After Intrauterine Death of Co-Twin
Jae Young Choi, Kook In Park, Ran Namgung, Chul Lee, Dong Gwan Han, Tae Sub Chung
Clin Exp Pediatr. 1994;37(5):701-706.   Published online May 15, 1994
Various anatomical defects have been described in the surviving twin who had a stillborn, macerated monozygotic co-twin Disseminated Intravascular Coargulation. The etiology is thought to be placental transfer of emboli or thromboplastic material through placental vascular anastomoses. We experienced a case of monozygotic twin with deceased co-twin at 30 weeks of gestation and confirmed to have antenatal periventricular germinal matrix and...
Original Article
Tc-99m HMPAO Brain SPECT in a Patient with Neonatal Seizure and Right Cerebral Hemiatrophy
Hye Young Kang, Kook In Park, Ran Namgung, Chul Lee, Chang Jun Coe, Dong Gwan Han, Tae Sub Chung, Woo Hee Jung
Clin Exp Pediatr. 1994;37(3):397-404.   Published online March 15, 1994
Functional brain imaging is very important in the diagnosis and evaluation of the various neurologic disorders. In addition to electroencephalography (EEG) and positron emission tomography (PET), single photon emission computed tomography (SPECT) have increasingly gained importance in determination of disturbances in regional brain functions. Both ictal and interictal Tc-99m hexamethyl-propyleneamine oxime single photon emission computed tomography (Tc-99m HMPAO SPECT) was done...
The Therapeutic Effects of Dexamethasone in Bronchopulmonary Dysplasia
Min Joong Kwon, Kook In Park, Min Soo Park, Ran Namgung, Chul Lee, Dong Kwan Han
Clin Exp Pediatr. 1993;36(12):1672-1680.   Published online December 15, 1993
We observed clinical features of 18 bronchopulmonary dysplasia (BPD) patients who were admitted to the neonatal intensive care unit in the Severance Hospital of Yonsei University College of Medicine from January 1. 1987 to June 30. 1991. Eight patients in whom ventilator settings were unchanged from for more than 5 days because of lack of improvement in pulmonary function. ...
Case Report
A Case of Transfusion-Associated Gragt-Verus-Host Disease in a Preterm Infant
Hye Jung Joo, Seung Mo Park, Ran Namgung, Kook In Park, Jin Sung Lee, Chul Lee, Dong Kwan Han, Kir-Young Kim, Kwang-Hoon Lee, Kwang-Gil Lee
Clin Exp Pediatr. 1993;36(11):1613-1620.   Published online November 15, 1993
Graft-versus-host disease is commonly observed after allogeneic bone marrow transplantation but rarely recognized transfusion or solid-organ transplantation. Transfusion-associated graft-versus-host disease can occur in immunosuppressed recipients and immunocompetent transplant recipients. The clinical manifestations of gastrointestinal or hepatic dysfunction, rash and pancytopenia should heighten the physician's index of suspicion for GVHD. Among premature infants, only four cases have been reported to develop...
A Case of Cerebrocostomandibular Syndrome with Congenital Heart Disease
Sang Heui Song, Kook In Park, Hye Jung Joo, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1993;36(4):574-578.   Published online April 15, 1993
Cerebrocostomandibular Syndrome is characterized by micrognathia, cleft palate, multiple thorax deformity and frequently, mental deficiency. Respiratory compromise is a common cause of death. We experienced a case of cerebrocostomandibular syndrome with congeniyal heart disease in a 2 day old female baby with the chief complaint of cyanosis and respiratory difficulty since birth, She was delivered by cesarian section due to delayed...
Medical Lecture Course
Rickets in the Newborn and Preterm Infants -Bone and Mineral Homeostais in the Perinatal and Neonatal Period-
Ran Namgung
Clin Exp Pediatr. 1992;35(12):1629-1638.   Published online December 15, 1992
Erratum
Measurement of Bone Mineral Density in Korean Newborns by Dual Photon Absorptiometry
Kook In Park, Chul Lee, Ran Namgung, Duk Hi Kim, Dong Gwan Han
Accepted January 1, 1970  
Bone mineral density (BMD), bone mineral content (BMC) and bone width (BW) of lumbar spine was measured in 37 term and 38 preterm appropriate-for-gestational-age (AGA) infants and 22 term small-for-gestational-age (SGA) infants who were delivered at Yonsei University Severance Hospital from January to September 1991 using dual photon absorptiometry (DPA). All of the infants were studied once within three days...
Original Article
Longitudinal Change of Cerebral Blood Flow Velocity in Neonates with the Doppler Technique
Kook In Park, Dong Gwan Han, Ran Namgung, Chul Lee, Jin Suk Suh, Myung Joon Kim
Clin Exp Pediatr. 1992;35(1):60-68.   Published online January 15, 1992
Eighty-one asymptomatic preterm, term-SGA, and full term infants who were delivered at Yonsei University Severance Hospital from January to July 1990 were studied with color duplex imaging doppler sonography to assess the postnatal changes of the cerebral blood flow velocity longitudinally. Pulsatility index (PI) and area under the velocity curve (AUVC) were calculated to quantitate changes in anterior cerbral artery blood...
A case of type VI Ehlers-Danlos syndrome.
Ki Soo Pai, Young Mi Chung, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1991;34(12):1717-1723.   Published online December 31, 1991
Ehlers-Danlos syndrome is an inherited hetergenous disorder of connective tissue with characteris- tic clinical manifestations. In this article, a case of Ehlers-Danlos syndrome is presented. A nine months old female was admitted due to developmental delay. On physical examination, she had soft velvety skin and corneal opacity. Both hip joints were positive for Barlow test. There was hyper- mobility of both knee and elbow...
A case of neonatal herpes simplex virus encephalitis.
Kook In Park, Young Mo Sohn, Dong Soo Kim, Ran Namgung, Chul Lee, Dong Gwan Han, Won Young Lee, Ki Keun Oh, Myung Joon Kim
Clin Exp Pediatr. 1991;34(9):1276-1285.   Published online September 30, 1991
Neonatal herpes simplex virus infection still remains a life-threatening infection for the newborn. With an increasing incidence of genital herpes and an increase in the incidence of neonatal herpes simplex virus infections, it is important that pediatricians and neonatologists continue to maintain a high index of suspicion in infants whose symptoms may be compatible with herpes simplex virus infections so that early identification leads...
Predictive factors and initial selection of antibiotics in neonatal sepsis.
Dong Chul Park, Chul Lee, Kook In Park, Ran Namgung, Dong Gwan Han
Clin Exp Pediatr. 1991;34(6):755-762.   Published online June 30, 1991
For simplifying and standardizing the interpretation of usual findings for neonatal sepsis, prenatal and perinatal factors, clinical symptoms and signs, method of management and hematologic findings were evaluated as a screening test. From the data obtained, a scoring system was formulated that assigns a score of 3 for diarrhea, 1. 5 for tachypnea, 1.5 for cyanosis, 1 for umbilical vessel catheterization, 1 for intravenous...
Effect of fluid restriction on postnatal weight and outcome in very low birth weight infants.
Chul Lee, Hyeon Soo Lee, Ran Namgung, Dong Gwan Han
Clin Exp Pediatr. 1991;34(3):348-354.   Published online March 31, 1991
We studied 45 very low birth weight infants for change in birth weight, urine output, serum Na level, ventilatory support and outcome between two groups after fluid restriction therapy. Group 1 (n=17) were infants whose weight loss were more than 5% of birth weight. Group 2 (n=17) were infants whose weight loss were more than 5% of birth weight. 1) Group 1 had more fluid...
The role of exchange transfusion as a therapy for neonatal DIC.
Jung Tak Kim, Kook In Park, Ran Namgung, Dong Gwan Han, Kir Young Kim
Clin Exp Pediatr. 1991;34(1):31-40.   Published online January 31, 1991
A clinical study on the effects of exchange transfusion on disseminated intravascular coagulation was conducted on 32 patients with DIC who were admitted to the pediatric department of YUMC from January 1984 to June 1989. We diagnosed DIC when symptoms were compatible to the diagnosis and there were more than 3 abnormal laboratory findings out of the following 5, which were platelet count, PT,...
Prolapse of Ileal Mucosa Through the Patent Omphalomesenteric Duct.
Hwan Gyu Park, Ki Soo Pai, Jeong Wan Yoo, Kook In Park, Ran Namgung, Chul Lee, Dong Gwan Han, Eui Ho Hwang, In Joon Choi
Clin Exp Pediatr. 1990;33(12):1713-1717.   Published online December 31, 1990
The omphalomesenteric duct in the embryo is a communication between the yolk sac and primitive gut. The duct closes by six to eight weeks of intrauterine life and disappears soon after. Patent omphalomesenteric duct is a congenital anomaly which occurs when there is incomplete closure of the duct during this period. The authors experienced a cases whereby a 29-day old male baby had patent...
Clinical Study of Umbilical Vessel Catheterization in Newborn Infants.
Dae Shik Kim, Kook In Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1990;33(11):1503-1509.   Published online November 30, 1990
Umbilical vessel catheterization has become a common procedure in critically ill newborn infants. We studied the usefulness and complications of indwelling umbilical vessel catheters in 164 patients who were admitted to the neonatal intensive care unit of the Department of Pediatrics, Yonsei University Hospital from January 1985 to December 1988. The results were as follows: 1) Their birth weights ranged from 650 to 3,800 gm, and...
Dubowitz Neurologic Examination in Normal Neonates.
Young Soo Lee, Soh Yeon Kim, Dong Chul Park, Kook In Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1990;33(7):977-988.   Published online July 31, 1990
With the improvement in survival rate in high risk infants in the neonatal intensive care unit, there is rising concern about the neurologic sequelae in these infants. In order to evaluate the neur- ologic examination in normal neonates, 400 normal newborns were evaluated for a duration of 6 months from Mach 1989 to August 1989. Neonates greater than 37 weeks gestational age, birth weight...
Exogenous Surfactant Replacement Therapy of Hyaline Membrane Disease: A controlled clinical trial.
Ran Namgung, Chul Lee, Kook In Park, Dong Gwan Han
Clin Exp Pediatr. 1990;33(1):22-34.   Published online January 31, 1990
We conducted a clinical controlled trial of exogenous surfactant replacement therapy in premature infants with hyaline membrane disease at the neonatal intensive care unit of Yonsei University Medical Center form Nov. 1987 to May 1988. Sixteen premature infants with severe HMD were randomly assigned to control group or surfactant-treated group. Eight infants (mean gestational age 29.9±2.8 week, mean birth weight 1, 425±308.9 gm) were given...
A case of congenital posterior choanal atresia.
Dae Shik Kim, Ran Namgung, Chul Lee, Dong Gwan Han, Seung Kyu Chung
Clin Exp Pediatr. 1989;32(11):1546-1552.   Published online November 30, 1989
The congenital posterior choanal atresia is an uncommon, but not rare, disorder that may threaten the newborn’s existence or give rise to chronic symptoms. As many as 50% of patients with choanal atresia have other associated anomalies. We experienced a case of congenital posterior choanal atresia without associated anomaly in 6 day old female baby. The patient was hospitalized due to the main symptoms...
A Study on Noninvasive Measurement of Blood Pressure in Normal Newborn.
Eun Hee Lee, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1989;32(9):1216-1223.   Published online September 30, 1989
Measurement of blood pressure in neonate is an important diagnostic procedure. But measurement of blood pressure were not performed routinely because of difficulty in measuring blood pressure and variable normal range according to measuring apparatus. Recently some accurate and convinient apparatuses of measuring blood pressure have been introduced in neonatal care, so normal blood pressure values of neonate are needed. In this study, we establish...
Ultrasonographic Diagnosis of Congenital Hypertrophic Pyloric Stenosis.
Shin Heh Kang, Chul Lee, Ran Namgung, Dong Gwan Han, Ki Keun Oh, Seung Hun Choi
Clin Exp Pediatr. 1989;32(6):756-764.   Published online June 30, 1989
The diagnosis of congenital hypertrophic pyloric stenosis has traditionally been made on the basis of history and physical examination in the majority of patients. Imaging procedures such as UGI series have been reserved for vomiting infats in whom the diagnosis was obscure. More recently ultrasonography with the lack of hazards associated with radiation provides an additional method of investigation which is accurate and diagnose...
Postnatal Weight Curve in Low Birth Weight(Appropriate for Gestational Age) Infants.
Kyoung Mi Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1989;32(5):606-619.   Published online May 31, 1989
Postnatal body weight changes were observed in 171 surviving infants with birth weights from 875 gm to 2,125 gm who were born at Severance Hospital, Yonsei University College of Medicine form 1981 to 1987. Only infants whose sizes were appropriate for gestational age were included in the study. Infants were divided into 5 groups by biπh weight, with the median weight were 2,000 gm,...
The Direct Coombs Test and Heat Elution Test in ABO Incompatible Hemolytic Disease of the Newborn.
Kook In PArk, Chul Lee, Ran Namgung, Dong Gwan Han, Kir Young Kim
Clin Exp Pediatr. 1988;31(12):1633-1640.   Published online December 31, 1988
The clinical study on 28 cases of ABO HDN who were diagnosed at Pediatric Department of Severance hospital and Yong Dong Severance hospital, Yonsei University for last 5 months was. And in these cases, heat elution test in combined with direct Coombs test using standard techniques were performed to evaluate the clinical significance of serological diagnosis. The following results were obtained. 1) Of 28 ABO HDN...
Neurosonographic Follow-up Study in Low Weight Infants.
Yil Sub Lee, Chul Lee, Ran Namgung, Dong Gwan Han, Ki Keun Oh
Clin Exp Pediatr. 1988;31(12):1573-1579.   Published online December 31, 1988
Serial neurosonographic examinations were performed in 34 low birth weight infants who were admitted to the neonatal intensive care unit of Yong-Dong Severance Hospital. Among them, 14 (41 %)were found to have periventicular-intraventricular hemorrhage. The initial hemorrhage occured in the first three days of life among 71% infants. After initial hemorrhage, hemorrhage was decreased in size and thereafter absorbed. Fourteen (44%) infants demonsrated cysts...
Bilirubin-Binding Capacity of Albumin in Korean Neonates.
Jung Bae Lee, Chul Lee, Ran Namgung, Dong Gwan Han, Kyung Son Song
Clin Exp Pediatr. 1988;31(10):1259-1266.   Published online October 31, 1988
The binding of bilirubin by albumin is thought to play an important role in the pathogenesis of kemictems. Free bilirubin hypothesis has led to develop methods to evaluate the binding capacity and affinity of bilirubin to albumin in the plasma. Horseradish peroxidase oxidation of free bilirubin can estimate the level of free bilirubin, bilirubin binding capacity and bilirubin binding affinity. Twenty four term infants...
7 Cases of Group B Streptococcal Meningitis and Sepsis.
Young Wan Kim, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1988;31(7):873-880.   Published online July 31, 1988
We report 7 cases of Group B streptococcal meningitis and sepsis. Six of the patients were admitted to the Department of Pediatrics, Severance Hospital and Youngdong Severance Hospital in 1986 and one was admitted in 1979. The age of onset ranged from 10 to 34 days of age and all were cases of late onset. The Clinical findings were fever, seizure, poor feeding,...
A Study on the Blood Pressure Measurements in Newborn.
Ran Namgung, Ki Soo Pai, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1988;31(5):541-546.   Published online May 31, 1988
Non invasive blood pressures measured by the Dinamap monitor, an oscillometric device, were compared with the invasive radial artery pressure in neonates. There were 21 patients with a mean age of 16.5 days (ranges 7 days to 1 month) and a mean body weight of 3.3 kg. The invasive radial artery pressures were recorded on a strip chart and comparisons were made between the...
A Case of Persistent Fetal Circulation.
Jong Kyun Lee, Chul Lee, Ran Namgung, Sung Kyu Lee, Dong Gwan Han
Clin Exp Pediatr. 1988;31(2):234-240.   Published online February 28, 1988
The authors have experienced a case of persistent fetal circulation associated with hypocalcemia. The baby was delivered with full-term by repeated cesarean section. He showed marked dyspnea 4 hours after birth and thereafter cyanosis appeared. So artificial ventilator had been applied combined with tolazoline administration. The patient was treated successfully and discharged on 28th hospital day without complications. We present one case of persistent fetal...
The Result of Intensive Care on the very Low Birth Weight Infants(1001~1500gm).
Seo Jeong Kim, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1988;31(1):29-39.   Published online January 31, 1988
The clinical study on the results of intensive care was performed on the 137 very low birth weight infants with birth weight of 1001-1500 gram who were admitted to the neonatal intensive care unit of Severance hospital from 1981 to 1986. The results were as follows. 1) The range of gestational age of very low birth weight infants was from 22 to 40 weeks, most predominantly...