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Original Article
Cardiology
Apoptosis and remodeling in adriamycin-induced cardiomyopathy rat model
Young Mi Hong, Hyeryon Lee, Min-Sun Cho, Kwan Chang Kim
Clin Exp Pediatr. 2017;60(11):365-372.   Published online November 27, 2017
Purpose

The mechanism for the pathogenesis of adriamycin (ADR)-induced cardiomyopathy is not yet known. Different hypotheses include the production of free radicals, an interaction between ADR and nuclear components, and a disruption in cardiac-specific gene expression. Apoptosis has also been proposed as being involved in cardiac dysfunction. The purpose of this study was to determine if apoptosis might play a role...

Myocardial Protective Effect of Cardioxane for the Myocardial Damage due to Doxorubicin
Hee-Ju Park, Jai-Min Oh, Sung-Hoon Kim, Chang-Hoon Lee, Sang-Sik Kim
Clin Exp Pediatr. 2003;46(9):876-882.   Published online September 15, 2003
Purpose : To find out the myocardial protective effect of cardioxane for the myocardial damage by doxorubicin. Methods : Using Eighteen rabbits(2.0-3.2 kg), doxorubicin(30 mg/m2) was injected intravenously once a week in group I(12 rabbits) and cardioxane(600 mg/m2) was injected at 20-30 minutes before doxorubicin administration in group II(6 rabbits). After this, we operated on the rabbits when the total cumulative...
The Study of the Changes of Myocardial Histology and Left Ventricular Function according to the Total Doses of Doxorubicin in Rabbits
Jeong Hwa Choi, Hee Ju Park, Young Tak Lim, Bong Seon Kim, Eun Young Huh
Clin Exp Pediatr. 2001;44(12):1395-1403.   Published online December 15, 2001
Purpose : We'd like to evaluate the relationship between the degree of cardiac damage and that of cardiac function according to the total injected dose of doxorubicin. Methods : 12 rabbits(body weight : 2.0-3.2 kg) were used and 30 mg/m2/week of doxorubicin hydrochloride was injected intravenously. The cardiac function was checked under anesthesia, after which the thorax was opened and cardiac samples were evaluated...
Case Report
Two Cases of Doxorubicin-induced Dilated Cardiomyopathy
Jin Won Park, Kyeong Ah Lee, Yong Woon Paik, Hyun Kee Chung, Jae Sun Park
Clin Exp Pediatr. 1992;35(6):822-828.   Published online June 15, 1992
Doxorubicin is an anthracycline antibiotic with a broad spectrum of activity in human neoplasms. However, this agent may cause, frequently, irreversible congestive left ventricular failure. We have experienced 2 cases of doxorubicin induced cardiomyopathy in one patient with multiple eosinophilic granuloma and another patient with T cell leukemia. Total dosage of doxorubicin was 295 mg/M2 for the 6 months duration and...
Original Article
A Case of Doxorubicin-induced Dilated Cardiomyopathy.
Sang Young Jeong, Soo Chun Kim, Sung Ho Cha, Young Mook Choi, Chang Il Ahn
Clin Exp Pediatr. 1989;32(8):1132-1137.   Published online August 31, 1989
Doxorubicin is one of the most effective chemotherapeutic agents in the treatment of leukemia, lymphoma and various solid tumors. Because of dose-dependent degenerative cardiomyopathy, however, doxorubicin theraphy may be discontinued ineffectively early. Doxorubicin-induced conges- tive heart failure carries a very poor prognosis since it is lethal in 60% of patients. Various methods for evaluating the cardiotoxic effect have been employed such as EKG, systolic...
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