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Case Report
A case of Kikuchi-Fujimoto disease with autoimmune thyroiditis
Eun Ji Go, You Jin Jung, Seung Beom Han, Byung Kyu Suh, Jin Han Kang
Clin Exp Pediatr. 2012;55(11):445-448.   Published online November 23, 2012

Kikuchi-Fujimoto disease (KFD) is a benign self-limiting disease characterized by fever and lymphadenitis. The etiology and pathogenesis of KFD is unclear. However, two hypotheses have been suggested: a viral infection hypothesis and an autoimmune hypothesis. Several KFD patients with various types of autoimmune diseases have been reported, and these reports support the hypothesis for autoimmune pathogenesis of KFD. Here, we...

Kikuchi-Fujimoto disease with aseptic meningitis
Se Jin Park, Won Jin Moon, Wan Seop Kim, Kyo Sun Kim
Clin Exp Pediatr. 2009;52(5):622-626.   Published online May 15, 2009
Kikuchi-Fujimoto disease was initially described as a self-limiting histiocytic necrotizing lymphadenitis in Japan in 1972, and is predominantly observed in women under the age of 30 year and in Asian populations. The pathogenesis is still poorly understood but is thought to include infections, and autoimmune and neoplastic diseases. The most common clinical manifestations are fever and painless cervical lymphadenitis. Diagnosis...
Original Article
Detection of HHV6 and EBV in histiocytic necrotizing lymphadenitis
Kyung Hee Park, Sung Shik Park, Ji Yeon Kim, Su Eun Park
Clin Exp Pediatr. 2008;51(9):987-991.   Published online September 15, 2008
Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis (HNL), is a self-limited disease characterized by cervical lymphadenopathy and fever. The etiology of KFD remains unknown; however, the self-limiting nature of HNL suggests the cause of this disease could be viral infection. For this reason, several viruses have been evaluated as possible etiologies of HNL, including Epstein-Barr virus (EBV), human...
Histiocytic necrotizing lymphadenitis in children : association of human herpes virus 8 and Epstein Barr virus
Hyun A Kim, Ju-Young Chung, Sang Woo Kim, Sung Jig Lim, Haeng Seop Shin
Clin Exp Pediatr. 2006;49(8):875-881.   Published online August 15, 2006
Purpose : The aims of this study were to analyze the clinical characteristics of children with Kikuchi's disease(KD) at a medical center and to investigate the etiologic role of human herpesvirus 8(HHV 8) or Epstein-Barr virus(EBV) in children with KD. Methods : Twenty six children who were diagnosed as KD between Jan. 1998 and Dec. 2005 were included....
Case Report
A case of Kikuchi's disease with skin involvement
Ji Min Jang, Chul Hee Woo, Jung Woo Choi, Dae Jin Song, Young Yoo, Kwang Chul Lee, Chang Sung Son
Clin Exp Pediatr. 2006;49(1):103-106.   Published online January 15, 2006
Histiocytic necrotizing lymphadenitis, which is also commonly referred to as Kikuchi's disease (KD), is a self-limiting disease of unknown etiology. It affects individuals of all ages, although it is usually seen in young women. However, only a few descriptions of this disease are available in the pediatric literature. KD is clinically characterized by cervical lymphadenopathy, high fever, myalgia, neutropenia and,...
A Case of Kikuchi-Fujimoto Disease, Subsequently Evolving to Systemic Lupus Eyrthematosus
Soon Hwa Yoon, Myoung Hoon Song, Seon Hee Shin, Sung Koo Kim, Kon Hee Lee, Hae Sun Yoon, Young Ok Jung, Hye Kyung Ahn
Clin Exp Pediatr. 2004;47(8):904-907.   Published online August 15, 2004
Kikuchi-Fujimoto disease(KFD), also known as histiocytic necrotizing lymphadenitis, is a self-limited systemic illness and it has the pathognomonic histological appearance of lymph nodes. KFD is rarely associated with systemic lupus erythematosus (SLE). The diagnosis of KFD can precede, postdate or coincide with the diagnosis of SLE. Our case describes a young woman, originally diagnosed as having Kikuchi's disease by lymph...
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