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In Kawasaki disease, coronary arterial involvement is an important prognostic factor. Many studies have reported about risk factors of coronary artery disease in Kawasaki disease. This study was designed to evaluate factors influencing coronary arterial involvement and to evaluate the effect of intravenous gammaglobulin (IVG) when admitted on the widely used criteria in Korea. Fiftyfour patients meeting the CDC criteria... |
In order to determine the normal values of coronary arterial dimensions in children, eighty eight children without any cardiovascular diseases were studied with cross-sectional echocardiography. Age ranged from 1 day to 15 years. Four sites (proximal right coronary artery, left main, left anterior descending, and left circumflex coronary artery) were selected to measure the dimensions. The right coronary artery was measured... |
The purpose of this study is to establish normal values for Doppler aortic and pulmonary artery flow velocity measurements, adjusted for age and the other parameters, which might be used for evaluating patients with suspected abnormalities of left and right sided hemodynamics. Blood flow velocity measurements were made in the ascending aorta and proximal main pulmonary artery of 117 pediatric normal... |
The authors studied the growth-promoting effect of yeast-derived methionyl-hGH in short statured children with uremic chronic renal failure. The subjects were prepubertal chronic renal insufficient patients whose height standard deviation scores were below -2.0. Two boys and two girls participated in this study. Chronic renal insufficiency was the only cause for the short stature. HGH was given to the subjects in dose... |
Respiratory distress syndrome(RDS) of preterm infants remains a significant cause of morbidity and mortality despite improvements in neonatal intensive care and artificial ventiratory techniques. After identification of the deficiency of pulmonary surfactant is major pathophysiologic basis in RDS, artificial surfactant replacement therapy in RDS was first successfully tested on RDS infants by Fujiwara and co-workers in 1980. Therefore, exogenous surfactant replacement... |
Carcinomas in childhood differ from those in adults in their frequency, histologic type, and distribution of primary sites. In children, carcinomas are rare and few series have been published containing sufficient mumbers of cases to permit a reliable account of the incidence and survival of children with carcinoma. During a 10-year period, 1982-1991, we observed 40 patients less than 16... |
The authors studied 24 cases of malignant neuronal tumors, 14 neuroblastomas and 10 ganglioneuroblastomas, immunohistochemically, using antibodies to neuroendocrine markers including neuron specific enolase (NSE), somatostatin, chromogranin, β-endorphin, and adrenocorticotrophic hormone (ACTH). The tissue specimens were obtained by biopsy or autopsy at Pusan National University Hopital and Pusan Paik Hospital from 1980 to 1989. The positive reactivity of markers in... |
Although lower respiratory tract infection is a major cause of childhood morbidity in Korea and respiratory viruses are presumed to be important pathogens, there have been few studies available. We diagnosed RSV infection by virus isolation and immunofluorescence in children with lower respiratory tract infection, seen at Seoul National University Children's Hospital from Nov. 1990 to Jul. 1991. The results were... |
Basic experimental approach for rapid and acurate detection of respiratory syncitial virus (RSV) infection at gene level has been performed using polymerase chain reaction (PCR). RSV RNA was extracted by RNAzolB methol from RSV which was cultured in Hep-2 cell line. Of RSV genome having about 8,000 base pairs, base pairs between 3237th and 3522nd were selected to make four... |
Antral or prepyloric mucosal diaphragms (webs) are composed of mucosa which enclose a membrane of submucosa and located at the antrum of the stomach at variable distances from the pylorus. They may be congential in origin or secondary to chronic peptic ulcer disease. Obstructive symptoms occur when diaphragmatic aperture is less than 1 centimeter. The diagnosis relies on the history,... |
Infection by Listeria monocytogenes, an uncommon pathogen in immunocompromised host, has been reported in neonates, pregnant women and adults with defective cell mediated immunity but not in children in Korea. It can cause sepsis, meningitis, abortion, premature labor, intrauterine fetal infection. etc. We have experienced L. monocytogenes sepsis and/or meningitis in three children under immunosuppresive therapy for lymphoma-leukemia, cytophagic histiocytic... |
Chronic intestinal pseudo-obstruction is a clinical condition in which impaired intestinal propulsion causes recurrent symptoms of bowel obstruction in the absence of mechanical occlusion. In this paper a female neonate was presented with vomiting and abdominal distension in the first few days of life but passed normal meconium. Barium enema showed a microcolon and an abnormaly sited cecum. Malrotation of bowel... |
Diagnosis of thymic hyperplasia may be quite difficult because thymus has not always sail appearance and it sometimes appears to be a huge mass in the mediastinum. This fact causes sometimes diagnostic thoracotomy or often make primary physicians fail in treatment and transfer their patients to other hospitals. But in most cases diagnosis can be made by a lateral chest... |
Severe combined immunodeficiency disease is caused by a group of genetic disease characterized by abnormal function of T and B lymphocytes. The treatment of choice for severe combined immunodeficiency disease is a HLA mached bone marrow transplant, but transplantation of cultured thymus epithelium was used to treat severe combined immunodeficiency disease in case of that mached, related bone... |
We experienced a case of salmonella group C meningits in a 3 month old male. His initial chief complaints at the admission were high fever, lethargy, irregular respiration and arrythmias. Diagnosis was confirmed by lumbar puncture, blood culture and CSF culture. Ceftriaxone was used and recovered with some sequelae such as irritability, generalized spasticity and mild regression of psychomotor development. |
We experienced a case of prune belly syndrome in a 2 days old female with deficient abdominal wall musculature and urinary tract anomalies which composed of bilateral multicystic kidney, left vesicoureteral reflux and megaureter with kinking in appearance and marked distended bladder. On ultrasonographic examination, there were no abnormalities in uterus, vagina and overies. A review of literatures was also presented briefly. |
Seronegative enthesopathy and arthropathy (SEA) syndrome is characterized by male predominance, late age onset, positive family histories of arthritis, oligoarthropathy, axial skeleton involvement, the presence of the B27 histocompatiboility antigen. It has been reported by Rosenberg and Petty in 1982. Early recognition of this syndrome destined to develop seronegative spondyiarthropathy is necessary to prevent axial spine dysfunction and defomity and... |
Fukuyama type congenital muscular dystrophy is characterized by mental retardation, progressive muscle weakness and hypotonia, joint contracture and seizures in half of the reported cases. The usual CT abnormalities are dilated cerebral ventricles and Sylvian fissures and lucency of cortical white matter. The most consistent pathologic findings in the brain are polymicrogyria and pachygyria, caused by a disturbance of migration... |