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Volume 44(6); Jun 2001
Medical Lecture Course
Evaluation and Treatment of Precocious Puberty
Byung-Kyu Suh
J Korean Pediatr Soc. 2001;44(6):607-613.   Published online June 15, 2001
Original Articles
A Study of Acute Poisoning in Korean Children
Chan Sook Park, Song Hyeun Eun, Mi Hwa Yang, Jin A Son, Jung Yun Hwang, Jae Wook Ko, Don Hee Ahn
J Korean Pediatr Soc. 2001;44(6):614-619.   Published online June 15, 2001
Purpose : The National Medical Center has been conducting a study as a Poison Control Center since 1998. The data was analyzed to illustrate the general aspects of acute poisoning in Korean children. Methods : The primary sources of data were collected from the Medical Insurance Records of 1997 and death records of the same period obtained from the Korea National Statistical Office. A total...
Effect of Parenteral Nutrition Guideline Changes on Neonatal Sepsis in Premature Infants
Chang-Ryul Kim, Jae-Won Oh, Myung-Kul Yum, Soo-Jee Moon
J Korean Pediatr Soc. 2001;44(6):620-626.   Published online June 15, 2001
Purpose : We hypothesized that decreased parenteral nutrition would lower the incidence of neonatal sepsis in premature infants. Methods : The study involves 223 premature infants who were admitted to the neonatal intensive care unit of Hanyang University Kuri Hospital from July 1995 to January 1999. Infants were divided into two groups based on different parenteral nutrition guidelines : Old...
A Clinical Study for Risk Factors of Cystic Periventricular Leukomalacia
Ji Eun Kim, Su Jin Kim, Woo Taek Kim
J Korean Pediatr Soc. 2001;44(6):627-634.   Published online June 15, 2001
Purpose : It is very important to study the individual risk factors which cause periventricular leukomalacia(PVL) and those which affect the process of cystic formation from liquefied periventricular white matter, in order to prevent and permit early diagnosis of cystic PVL that contributes to mortality and neurologic sequelaes in preterm infants. Therefore, the present study was designed to assess the...
Evaluation of Health Status and Growth and Developmental Outcome of Intrauterine Growth-Retarded Infants
Il Tae Hwang, Eun Ae Park, Ho Seong Kim, Gyoung Hee Kim
J Korean Pediatr Soc. 2001;44(6):635-641.   Published online June 15, 2001
Purpose : Although many children born with intrauterine growth retardation demonstrate significant catch-up growth in early childhood, substantial weight and height deficits remain in others. In addition, children with IUGR may demonstrate developmental deficits. The aims of this study are to evaluate the health status, growth and deveolpmental outcome of intrauterine growth retarded infants. Methods : Sixty five intrauterine growth retarded...
Survey on Upper Respiratory Tract Infections in Children
Seok Won Park, Hwang Min Kim, Jong Soo Kim, Kyu Earn Kim
J Korean Pediatr Soc. 2001;44(6):642-653.   Published online June 15, 2001
Purpose : Recently, the numbers of non-pediatric doctors' giving medical treatment to children has shown a tendency to increase, especially in case of upper respiratory infection(URI) and it's complications such as tonsillitis, sinusitis and otitis media. Therefore we surveyed parents on children's URI and complications to find out parents' general understandings on pediatric treatment, what kind of pediatric treatment they...
Anti-angiogenesis and Anti-metastasis Characteristics of the Novel Tumor Suppressor Gene PTEN
Pyoung Han Hwang, Ho Keun Yi, Myoung Hee Han, Dae Yeol Lee, Dae Yeol Lee, Jung Soo Kim
J Korean Pediatr Soc. 2001;44(6):654-663.   Published online June 15, 2001
Purpose : The tumor suppressor gene PTEN/MMAC1 is mutated in a variety of advanced and metastatic cancers, strongly suggesting that PTEN/MMAC1 alterations may be involved in tumor progression and the formation of metastases. However, the roles of PTEN in tumor growth and metastasis and its functional mechanisms are not fully understood. We evaluated the tumor suppressor function of PTEN/MMAC1 gene...
Mean Corpuscular Hemoglobin Concentration as a Discriminating Tool between Hereditary Spherocytosis and Intravascular Hemolysis
Hae Young Park, Hwang Min Kim, Kyoung Ah Lee, Dong Il Won, Sei Myeng Park, Seok Won Park, Baek Keun Lim, Kil Young Kim
J Korean Pediatr Soc. 2001;44(6):664-668.   Published online June 15, 2001
Purpose : The purposes of this study were to elucidate the diagnostic significance of mean corpuscular hemoglobin concentration(MCHC) for various kinds of hemolytic anemia, the mechanism of elevated MCHC in hereditary spherocytosis(HS). Methods : The subjects consisted of 39 cases of HS(group 1), 31 cases of intravascular hemolysis (IH) such as DIC, snake bite or hemolytic uremic syndrome(group 3), and sex...
Risk Factors for Fatty Liver in Obese Children
Ki Won Park, Jong Eun Lee, Kyung Ha Ryu, Kyung Hyo Kim, Young Mi Hong, Gyung Hee Kim, Keun Lee, Jeong Hyun Yoo
J Korean Pediatr Soc. 2001;44(6):669-676.   Published online June 15, 2001
Purpose : The incidence of obese patients has increased recently in Korea. Obesity is associated with hypertension, hyperlipidemia, insulin resistance, and fatty liver. Since recent investigators have revealed that not only fat accumulation but also fibrosis and nonspecific hepatitis can be found in the livers of obese children, fatty liver is currently considered as an important complication. The purpose of...
The Optimum Dose of Oral Diazepam to Reduce Seizure Attack in Febrile Seizure Patients During Febrile Illness
Im Jeong Choi, Je Eun Choi, Jung A Lee, Pil Ju Jeong, Sung Mi Kim, Jin Hwa Jeong, Jeong Ho Lee
J Korean Pediatr Soc. 2001;44(6):677-682.   Published online June 15, 2001
Purpose : Febrile seizure is the most common type of seizure affecting 3-4% of children. The recurrence rate of febrile seizure is approximately 33%. About 16% of children with a febrile seizure during the febrile illness have a recurrent seizure attack within 24 hours. This study aimed to investigate the optimum dose of diazepam to reduce the recurrence of febrile...
Case Reports
A Case of 18 Ring Chromosome
Joong Hyun Bin, Moon Young Song, In Goo Lee, Won Bae Lee, Byung Churl Lee
J Korean Pediatr Soc. 2001;44(6):683-686.   Published online June 15, 2001
A ring 18 chromosome(18r) karyotype is a rare disorder characterized by short stature, obesity, microcephaly, mental retardation, micropenis, cryptorchidism, hypertelorism, epicanthal folds, micrognathia, and small hands with short tapering fingers. A 22-month-old girl was referred to our department of pediatrics because of ptosis and delayed development. Karyotype revealed ring 18 and dicentric ring 18 chromosome(46,XX,r(18)[45]/45,XX,-18[7]/46,XX,dic r(18)[3]). Fluorescent in situ hybridization...
A Case of Chronic Active Epstein-Barr Virus Infection with Coronary Aneurysm
Hee Jeong, Bong Seong Kim, Ok Ja Choi, Han Wook Yoo, So Duk Lim, Soo-Jong Hong
J Korean Pediatr Soc. 2001;44(6):687-693.   Published online June 15, 2001
Chronic active Epstein-Barr virus infection(CAEBV) is a nonfamilial syndrome that shows a specific immunodeficiency for the Epstein-Barr virus(EBV). CAEBV is characterized by fever, lymphadenopathy, splenomegaly, hepatitis, interstitial pneumonitis, interstitial nephritis, and uveitis. Cardiovascular complications are rare in EBV infection. Patients with CAEBV show characteristically high titers of anti-viral capsid antigen(VCA) IgG antibody and anti-early antigen(EA) antibody, as well as relatively...
Zellweger Syndrome : First Confirmed Neonatal Case in Korea
Sung Sin Kim, Yun Hwa An, Yun Sil Chang, Dong Kyu Jin, Won Soon Park, Moon Hang Lee, Jong Won Kim, Hye Kyoung Yoon, Bo Kyoung Kim
J Korean Pediatr Soc. 2001;44(6):694-698.   Published online June 15, 2001
We describe below a case of Zellweger syndrome case with facial dysmorphism, profound hypotonia, and hepatomegaly. He died at the age of 2 months. Zellweger syndrome is a disease marked by the absence of hepatic and renal peroxisomes. Because peroxisomes have many vital anabolic and catabolic functions within the cell, their absence results in profound cellular dysfunction. A biochemical study...
Two Cases of Primary Segmental Infarction of the Greater Omentum
Do Yeon Kim, Weon Park, Dong Jin Lee, Jung Hyeok Kwon
J Korean Pediatr Soc. 2001;44(6):694-699.   Published online June 15, 2001
Primary segmental infarction of the greater omentum is a rare condition which usually simulates acute appendicitis or cholesystitis because of right-sided abdominal pain, tenderness, fever and leukocytosis. Its cause is unknown. Most authors believe that the condition results from an embryologic variant associated with anomalous and fragile blood supply of the right lower portion of the greater omentum, which is...
A Case of Congenital Methemoglobinemia Due to NADH-Methemoglobin Reductase Deficiency
Do Hyeon Kim, Jin A Lee, Sung Jae Lee, Heui Seung Jo, Yun Kyoung Lee, June Dong Park, Beyong Il Kim, Jung-Hwan Choi, Dong Soon Lee, Han Ik Cho, Kyung Ran Park
J Korean Pediatr Soc. 2001;44(6):699-704.   Published online June 15, 2001
Congenital methemoglobinemia is caused by NADH-methemoglobin reductase deficiency in more than half of the total reported cases. NADH-methemoglobin reductase deficiency is an uncommon hereditary disorder producing methemoglobinemia and cyanosis in the homozygous subject. A majority of the patients born with these abnormalities have only a cosmetic defect-asymptomatic cyanosis. Congenital methemoglobinemia due to NADH-methemoglobin reductase deficiency is an autosomal recessive disorder...
A Case of Late Presentation of Traumatic Diaphragmatic Hernia in a Child
Jin Young Jeong, Hyun Mi Kim, Je Kyoun Shin
J Korean Pediatr Soc. 2001;44(6):705-708.   Published online June 15, 2001
Traumatic diaphragmatic injuries in infants and children are uncommon. Late presentation of such an injury is well recognised in adults but is exceptionally rare in children. Because of the increased compliance of the thoracic cage in children, rupture of the diaphragm can occur without signs of external injury. Morbidity and mortality can be minimized by a high index of suspicion,...
Three Cases of Urine Abnormalities Associated with Ketogenic Diet
Hye Won Hahn, Ki Jung Kim, Il Soo Ha, Hae Il Jung, Yong Seung Hwang, Yong Choi
J Korean Pediatr Soc. 2001;44(6):709-713.   Published online June 15, 2001
Ketogenic diet is a high-fat, low carbohydrate, low protein diet used in treatment of pediatric epilepsy since the 1920s. Currently it is used primarily to treat refractory childhood epilepsy. Few serious complications caused by ketogenic diet have been reported. Short-term complications include dehydration, hypoglycemia, vomiting, diarrhea, and refusal to eat. Long-term complications include kidney stones, recurrent infections, metabolic derangement, hypercholesterolemia,...
49, XXXXY Syndrome with Multicystic Kidney in a Neonate
Eun Young Park, Soo Jee Moon
J Korean Pediatr Soc. 2001;44(6):714-717.   Published online June 15, 2001
The 49, XXXXY Klinefelter variant is distinctive; classic findings include mental retardation, hypogonadism and radioulnar synostosis. Its incidence is estimated to be 1/80,000 to 1/100,000 male births. We report a case of 49, XXXXY syndrome confirmed by chromosomal study in neonatal period, whose clinical features included a coarse face, short neck, micropenis, and other multiple minor anomalies including simian creases....
Two Cases of Leigh Disease in Siblings
Su Jin Kim, Ji Eun Kim, Hei Won Hwang, Ji Sun Mok, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim
J Korean Pediatr Soc. 2001;44(6):718-722.   Published online June 15, 2001
Leigh disease is a familial and degenerative disorder characterized by focal, bilateral, and usually symmetric lesions of the both gray and white matter in the brain and the spinal cord. The clinical course is variable, but in most cases, the prognosis is poor with subacute progression leading to death within months or years of life. The pathogenesis was known as...
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