Clinical and Experimental Pediatrics

Search

Page Path

HOME
Search

Review Article

Balancing therapeutic benefits and hidden risks of proton pump inhibitors in pediatric practice: a narrative review and update

Maria Rogalidou, Alexandra Papadopoulou

Proton pump inhibitors (PPIs) effectively treat acid-related disorders, including gastroesophageal reflux disease, eosinophilic esophagitis, peptic ulcers, and Zollinger-Ellison syndrome. Long-term use, particularly in children, may lead to microbiome alterations, nutrient deficiencies, infections, renal injury, osteoporosis, fractures, and other gastrointestinal changes. PPI therapy should be guided by clear clinical indications, prescribed at the lowest effective dose for the shortest necessary duration, and regularly reassessed to minimize risks in young children.

DOI: https://doi.org/10.3345/cep.2025.02761 [Epub ahead of print]

MOST CITED AHEAD-OF PRINT

Cited By 37	Prevalence of anxiety, depression, and stress among parents of neonates admitted to neonatal intensive care unit: a systematic review and meta-analysis
Cited By 28	Community-acquired pneumonia in children: updated perspectives on its etiology, diagnosis, and treatment
Cited By 26	Microplastic and human health with focus on pediatric well-being: a comprehensive review and call for future studies
Cited By 20	Development of orphan drugs for rare diseases
Cited By 18	Neonatal family-centered care: evidence and practice models

+more

Early prediction of bronchopulmonary dysplasia using new classification in high-risk preterm infants

Multiomics approaches in Kawasaki disease: insights into pathogenesis and emerging directions for diagnosis and treatment

Balancing therapeutic benefits and hidden risks of proton pump inhibitors in pediatric practice: a narrative review and update

Can a basophil activation test of cord blood predict a cow's milk allergy?

Granulocyte transfusion improves survival in pediatric febrile neutropenia: a 15-year cohort study

+more

ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES

FOR CONTRIBUTORS

ABOUT

Editorial Office: Korean Pediatric Society
#1606 Seocho World Officetel, 19 Seoun-ro, Seocho-ku, Seoul 06732, Korea
Tel: +82-2-3473-7306 Fax: +82-2-3473-7307 E-mail: office@e-cep.org

Clinical and Experimental Pediatrics is an open access journal. All articles are distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/)