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Review Article

Suture stem cells in pediatric craniosynostosis: pathophysiological mechanisms, surgical management, and emerging regenerative therapies

Fangxin Guo, Guodong Song

Craniosynostosis (CS) is a complex congenital disorder characterized by the premature fusion of one or more cranial sutures resulting from interactions between genetic alterations, environmental influences, and the dysregulated differentiation of cranial suture stem cells (SuSCs). Increasing evidence indicates that SuSC homeostasis disruption, including alterations in glioma-associated oncogene homolog 1-positive, axis inhibition protein 2-positive, and other stem/progenitor cell populations, along with aberrant regulation of developmental signaling pathways, plays a central...

DOI: https://doi.org/10.3345/cep.2026.02299 [Accepted]

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