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Neurology

Cognitive outcomes in late childhood and adolescence of neonatal hypoxic-ischemic encephalopathy

Bo Lyun Lee, Hannah C. Glass

Clin Exp Pediatr. 2021;64(12):608-618. Published online May 24, 2021

Web of Science 39 Crossref 40

∙ Cognitive impairments occur in children with hypoxic-ischemic encephalopathy (HIE) even without neuromotor deficits.
∙ Therapeutic hypothermia has improved neurodevelopmental outcomes of children with HIE; however, 40% of children remain at risk of death/disability or cognitive impairments necessitating the development of adjunctive neuroprotective therapies.
∙ Long-term follow-up until adolescence is required to identify cognitive dysfunction.
∙ A pattern of watershed injury on brain imaging is associated with poor cognitive outcomes.

DOI: https://doi.org/10.3345/cep.2021.00164

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