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Original Article

Association between sodium content of intravenous immunoglobulin and electrolyte changes and clinical course of Kawasaki disease

Yoshitaka Watanabe, Naomi Yagi, Toya Hattori, Chisato Oyake, Shota Endo, Maria Yoshimi, Takayoshi Kyoda, Hirokazu Ikeda

Background: Intravenous immunoglobulin (IVIG) formulations used to treat Kawasaki disease differ markedly in sodium content; however, the clinical significance of this factor remains unclear.
Purpose: Here we investigated whether sodium content influences electrolyte changes and short-term clinical outcomes of Kawasaki disease. Methods: This single-center retrospective cohort study included 744 children with first-episode Kawasaki disease treated with 2-kg IVIG in 2010–2020. The patients...

DOI: https://doi.org/10.3345/cep.2026.00619 [Accepted]

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