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Network-based biomarkers in pediatric drug-resistant epilepsy

Joseph Lim, Jaeso Cho, Hunmin Kim

Clin Exp Pediatr. 2026;69(8):636-638. Published online July 24, 2026

Conventional preoperative evaluation in pediatric drug-resistant epilepsy relies on clinical surrogates that quantify seizure exposure but not its impact on brain networks. A newly developed diffusion-weighted imaging connectome biomarker, anchored to intracranial electroencephalography-confirmed seizure onset zones and resolved across 6 neurocognitive domains, addresses this gap. This individualized approach classifies cognitive impairment with high accuracy and may offer a more precise, clinically interpretable tool to inform surgical timing.

DOI: https://doi.org/10.3345/cep.2026.01774

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