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Original Article

Effect of endothelin receptor blockade on monocrotaline-induced pulmonary hypertension in rats

Kyoung Ah Lim, Jung Yun Shim, Sang Ho Cho, Kwan Chang Kim, Jae Jin Han, Young Mi Hong

Clin Exp Pediatr. 2009;52(6):689-695. Published online June 15, 2009

Purpose : To examine the effect of bosentan, a dual endothelin receptor (ER) antagonist, on the development of monocrotaline (MCT)-induced pulmonary hypertension in rats by especially focusing on the pulmonary vascular morphology changes. Methods : Sprague-Dawley rats were treated as follows: controls received a subcutaneous saline injection, MCT-treated rats received a subcutaneous MCT injection, and bosentan-treated rats received a MCT...

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