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Purpose : We hypothesized dexrazoxane(DXR) and pentoxifylline(PTX) may prevent myocardial damage in adriamycin(ADR)-induced cardiomyopathic rat model. We also investigated their effects on the myocardial apoptosis and fibrosis in ADR induced cardiomyopathy.
Methods : The six-week old female Spregue-Dawley rats were divided into control group(CNT, n= 4), ADR group(n=6), ADR＋DXR group(DXR, n=5), ADR＋PTX group(PTX, n=6), ADR＋DXR＋PTX group(DXPT, n=5). ADR(5 mg/week, twice) was... |
