Clinical and Experimental Pediatrics

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Original Article

Clinical significance of loss of p16 protein by immunohistochemical staining in acute lymphoblastic leukemia

Hye Young Jin, Kyoung In Kang, Sun Young Kim, You Sook Youn, Joon Won Kang, Deog Yeon Jo, Kye Chul Kwon, Kyung Duk Park

Clin Exp Pediatr. 2008;51(1):73-77. Published online January 15, 2008

Purpose : p16 gene, mapped to the 9p21 chromosomal region, has emerged as a candidate tumor suppressor gene in human neoplasm. It is an inhibitor of cyclin-dependent kinase and inhibits Rb phosphorylation. In a variety of tumors including childhood acute lymphoblastic leukemia (ALL), deletion and/or mutation of the p16 gene has been found. Despite their high frequency, the prognostic importance...

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