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Original Article

Analysis of Platelet Membrane Glycoprotein Ⅱb-Ⅲa complex in Whole Blood of Glanzmann's Thrombasthenia by Flow Cytometry

Byoung Geun Lee, Man Choon Kang, Jong Man Park, Pyung Han Hwang, Jung Soo Kim

Clin Exp Pediatr. 1994;37(11):1540-1547. Published online November 15, 1994

Glanzmann's thrompasthenia is a rare autosomal recessive hemorrhagic disorder characterized by prolonged bleeding time, and deficient or absent clot retraction in the presence of normal platelet count. The major underlying abnormality in this disease is grossly defective first-phase aggregation of platelet, which are unresponsive to ADP or other platelet agonists such as epinephrine, collagen, thrombin in any concentration. This disability...

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