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Review Article

NLRP3 inflammasome: A key player in neonatal brain injury

Cagla Kiser, Ilkcan Ercan, Defne Engur, Sermin Genc

Among neonates, hypoxic-ischemic encephalopathy is the most significant cause of mortality and hypoxia-ischemia is among the leading causes of brain damage. The microglia are primary mediators of neuroinflammation. NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation is the first line of defense in the central nervous system. Numerous studies have shown that the NLRP3 inflammasome is activated and...

DOI: https://doi.org/10.3345/cep.2024.01935 [Accepted]

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