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Original Article

Effect of GCV on Neuroblastoma Cell Line Expressed by HSV-TK Gene with Retroviral Vector

Hyun Sang Cho, Chuhl Joo Lyu, Yeun Soo Kim, Tae Soo Kim, Byung Soo Kim

Clin Exp Pediatr. 1997;40(12):1719-1724. Published online December 15, 1997

Background : Gene transfer with vectors derived from murine retroviruses is restricted to cells which are proliferating and synthesizing DNA at the time of infection. Accordingly, selective introduction of genes encoding for susceptibility to otherwise nontoxic drugs(suicide genes) into proliferating tumor may be used to treat cancer. We investigated the efficacy of in vitro transduction of neuroblastoma cell with the herpes simplex-thymidine kinase(HSV-tk) gene followed...

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