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Original Article
The Preventive Effect of Dexrazoxane and Pentoxifylline on Adriamycin Induced Cardiomyopathy
Ling Zhu, Eun-Jung Bae, Il-Soo Ha, Jung-Wook Seo, Chung-Il Noh, Jung-Yun Choi, Yong-Soo Yun
Clin Exp Pediatr. 2005;48(12):1378-1384.   Published online December 15, 2005
Purpose : We hypothesized dexrazoxane(DXR) and pentoxifylline(PTX) may prevent myocardial damage in adriamycin(ADR)-induced cardiomyopathic rat model. We also investigated their effects on the myocardial apoptosis and fibrosis in ADR induced cardiomyopathy. Methods : The six-week old female Spregue-Dawley rats were divided into control group(CNT, n= 4), ADR group(n=6), ADR＋DXR group(DXR, n=5), ADR＋PTX group(PTX, n=6), ADR＋DXR＋PTX group(DXPT, n=5). ADR(5 mg/week, twice) was...
Evaluation of Prognostic Factors in Corrected Transposition of the Great Arteries at Mid-term Follow-up
Young-Hwan Song, Hyok-Joo Kwon, Gi-Beom Kim, Soo-Jung Kang, Eun-Jung Bae, Chung-Il Noh, Yong-Soo Yun, Jeong-Ryul Lee, Yong-Jin Kim, Joon-Ryang Rho
Clin Exp Pediatr. 2003;46(2):154-161.   Published online February 15, 2003
Purpose : The prognosis of patients with corrected transposition of the great arteries(C-TGA) is variably affected by associated intracardiac defects, systemic right ventricular function, tricuspid valve competence, and conduction disturbances. This study aims to evaluate the importance of those factors at mid-term follow-up. Methods : Medical records of 94 patients(males 58, females 36; mean age at last follow-up, 12? years; mean...
Clinical Trends in Acute Rheumatic Fever in Korean Children : Mailed Questionnaire Survey from 1988 to 1997 (Compared with 1978-1987)
Hyeon-Ho Kang, Sung-Ho Cha, Kyong-Su Lee, Sang-Bum Lee, Tae-Chan Kwon, Young-Chang Tockgo, Chang-Sung Son, Jin-A Son, Hee-Ju Park, Yong-Soo Yun, Jung-Yun Choi, Chang-Hwi Kim, Chul-Ho Kim, Tai-Ju Hwang, Jae-Sook Ma, Chan-Uhng Joo, Nam-Su Kim
Clin Exp Pediatr. 1999;42(10):1381-1391.   Published online October 15, 1999
Purpose : The purpose of this study was to assess the frequency of acute rheumatic fever(ARF) among children in Korea and to describe trends in its clinical characteristics compared to data from a previous study(1978-1987). Methods : A mailed questionnaire survey sent to the pediatric departments of 13 general hospitals in Korea requested the total number of patients with ARF and...
Developmental Morphology of the Atrial Venous Component in the iv/iv Mouse
Young-Hwue Kim, Yong-Soo Yun, Jeong-Wook Seo
Clin Exp Pediatr. 1998;41(7):931-940.   Published online July 15, 1998
Purpose : Developmental processes of atria in embryos or fetuses of the iv/iv mouse were studied to find the differences between right and left atrial chambers and to identify the characteristics of atrial isomerism in the abnormal laterality syndrome. Methods : Seventy-three embryos from SI/Col iv/iv mice(Jackson's laboratory, USA) or fetuses at the 10th-13th day were used. They were examined using...
Studies on the diuretic activity of the serum of the patient with diabetes insipidus
Kook-Choo Rie, Yong-Soo Yun, Ho-Sung Lee, Jeong-Ki Seo, Dong-Hwan Lee
Clin Exp Pediatr. 1976;19(2):99-112.   Published online February 28, 1976
Diabetes insipidus is the syndrome which results from abnomality in production or release of ADH. Recently there have been used two nonhormonal forms of therapy in the treatment of DI: 1)Various diuretics, primarily thiazides and 2)The oral hypoglycemic agents, the sulfonlureas. Arduino and other numerous invesgators demnstrated that sulfonylurea chlorpropamide (Diabinase) and tolbutamide(Drinase) had a ADH-Iike effect in a patient...