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Original Article

Effects of Cisapride on Action Potential Duration and on ATP-Sensitive K Channel in Guinea Pig Ventricular Muscles

Chan Uhng Joo, Young Jae Kim, Sung Ki Mun, Soo Wan Chae

Clin Exp Pediatr. 1999;42(7):953-958. Published online July 15, 1999

Purpose : Cisapride(PrepulsidⓇ) has been recently associated with long QT syndrome. It has been reported to cause Torsades de Pointes and induce early afterdepolarization in rabbit Purkinje fibers. We investigated the electrophysiological effects of cisapride on cardiac action potential duration and ATP-sensitive K channel in papillary muscles. Methods : Cardiac action potentials in guinea pig papillary muscle were recorded with microelectrodes...

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