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Original Article
Follow-up Studies and Clinical Significance of Chromosomal Rearrangement in Childhood Acute Lymphocytic Leukemia
Yang Hyun Kim, Jung Tae Kim, Jung Chul Kang, Hae Sik Kwon, Sung Chul Won, Seung Hwan Oh, Chuhl Joo Lyu
Clin Exp Pediatr. 2004;47(8):861-867.   Published online August 15, 2004
Purpose : Through routine screening for chromosomal defects present in patients with acute lymphocytic leukemia(ALL) by means of reverse transcription-polymerase chain reaction(RT-PCR), we aimed for earlier detection of recurrences, hence evaluating the progress of the disease after treatment, and forecasting the need for further testing. Methods : We analyzed 30 patients who visited the Pediatrics Department of Severance Hospital, from...
A Study of Clinical Features of Acute Tumor Lysis Syndrome in Children
Ick-Jin Song, Young-Tak Lim
Clin Exp Pediatr. 2000;43(7):952-958.   Published online July 15, 2000
Purpose : Tumor lysis syndrome is characterized by hyperuricemia, hyperphosphatemia, hyperkalemia and hypocalcemia due to destruction of tumor cells. The purpose of this study is to estimate in children the incidence, onset time, differences in outcomes between hemodialysis and conservative therapy, and predictive factor of tumor lysis syndrome before treatment with chemotherapy. Methods : Subjects were 108 children who had received...
Renal size as a Prognostic Factor in Childhood Acute Lymphocytic Leukemia
Soo Kyung Yun, Chang Hyun Yang, Chuhl Joo Lyu, Seung Hwan Oh, Kir Young Kim, Myung Joon Kim
Clin Exp Pediatr. 1994;37(2):174-179.   Published online February 15, 1994
The Kidney size is of special interest during the diagnostic work up of acute lymphocytic leukemia. But is still uncertain whether a finding of kidney enlargement at presentation has long-term prognostic value. We therefore reviewed the kidney size in children with acute lymphocytic leukemia by abdominal ultrasonograms at the time of diagnosis (n=54) and examined if there was any statistical...
Intermittent Central Nervous System Irradiation and Intrathecal Chemotherapy for Recurrent Central Nervous System Leukemia in Children
Joon Ho Bang, Nak Gyun Chung, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee, Man Kyu Yang
Clin Exp Pediatr. 1993;36(8):1067-1072.   Published online August 15, 1993
Between 1986 and 1990, four children with recurrent CNS leukemia who had previous NS prophylaxis therapy were treated with intermittent central nervous system irradiation and intrathecal chemotherapy (IIC). There was no isolated CNS recurrence. One patient died from bone marrow relapse. Three patients are alive without evidence of disease for 33/12 year to 36/12 years after the diagnosis of recurrence...
Plasma Levels of Oral Methotrexate in Children Receiving Maintenance Chemotherapy for Acute Lymphocytic Leukemia
Soo Kwan Lee, Kih Yeon Song, Young Hee Hwang, Young Hwan Lee, Jeong Ok Hah, Chun Dong Kim
Clin Exp Pediatr. 1993;36(7):936-943.   Published online July 15, 1993
This study was conducted to investigate plasma levels of oral methotrexate in rabbits and children receiving maintenance chemotherapy for acute lymphocytic leukemia. Eight New Zealand white rabbits, weighing 2kg in body weight, were divided into 3 groups and 5mg of methotrexate from 3 different manufactorying company was administered to the each group rabbits via nasogastric tube. Time to peak concentration ranged from...
A Clinical Study of Testicular Relapse in Childhood Acute Lymphocytic Leukemia
Hye Ok Roh, Chuhl Joo Lyu, Seung Hwan Oh, Chang Hyun Yang, Kir Young Kim, Byung Soo Kim
Clin Exp Pediatr. 1993;36(5):680-686.   Published online May 15, 1993
From January 1984 to June 1991, we studied testicular relapsed patients among 105 cases of acute lymphocytic leukemia in children who were admitted to the Department of Pediatrics and Yonse Cancer Center, Yonsei University Severance Hospital. The results were as follows: 1) 15 out of 105(14.4%) cases of acute lymphocytic leukemia were diagnosed as testicular relapse. According to the prevalence by the...
The effects of 1800 vGy cranial irradiation on intellectual function of children with acute lymphocytic leukemia.
Soo Ho Ahn, Jeong Ok Hah, Jung Hoon Lee
Clin Exp Pediatr. 1991;34(12):1683-1688.   Published online December 31, 1991
This study was conducted to investigate the effects of CNS prophylaxis with 1800 cGy cranial irradiation and intrathecal methotrexate (MTX) chemotherapy on intellectual function of the chil- dren with acute lymphocytic leukemia (ALL). Thirteen longterm survivors with ALL who were treated with 1800 cGy cranial irradiation and intrathecal MTX for CNS prophylaxis at pediatric department of Yeungnam University Hospital from May, 1983 to November, 1988...
A Case of Diabetic Ketoacidosis Associated with Acute Lymphocytic Leukemia during Remission Induction Chemotherapy.
Gyu Jin Oh, Hwa Jeong Lee, Heui Jeong Kwon, In Sil Lee
Clin Exp Pediatr. 1990;33(11):1598-1603.   Published online November 30, 1990
L-asparaginase is known as an effective anticancer drug in the induction chemotherapy of acute lymphocytic leukemia. The side effects or toxicities of L-asparaginase are hypersensitivity reaction, hepatotoxicity, pancreatitis, transient diabetes mellitus, CNS toxicity, disorders of coagulation system and mild cytotoxicity. We report a female patient with acute lymphocytic leukemia develop- ing diabetic ketoacidosis during induction chemotherapy with L-asparaginase, parednisolone, vincris- tine and intrathecal methotrexate, who...
Cyclophosphamide-Induced Hemorrhagic Cystitis in Acute Lymphocytic Leukemia and Non-Hodgkin Lymphoma.
Young Seo Park, Il Soo Ha, Soon Ki Kim, Hae Il Jung, Yong Choi, Hyo Seop Ahn
Clin Exp Pediatr. 1989;32(5):665-669.   Published online May 31, 1989
We studied the cyclophosphamide-induced hemorrhagic cystitis in 72 cases of acute lymphocytic leukemia or Non-Hodgkin lymphoma, which had been treated at Seoul National University Children' s Hospital from June, 1985 to May, 1988 1) Among 72 cases treated with cyclophosphamide, 6 cases(12.8%) developed hemorrhagic cystitis in 47 cases of acute lymphocytic leukemia and 2 cases(8.0%) in 25 cases of Non-Hodgkin lymphoma. 2) The development of...
Case Report
A Case of Acute Lymphocytic Leukemia Successfully Treated with Allogeneic Bone Marrow Transplantaion.
In Kyung Sung, Byung Churl Lee, Kyong Su Lee, Du Bong Lee, Chong Won Park, Chun Choo Kim, Dong Jip Kim
Clin Exp Pediatr. 1985;28(8):805-811.   Published online August 31, 1985
A 8-year old boy with acute lymphocytic leukemia who had shown resistance to repeated combination chemotherapies, was successfully grafted with bone marrow from his HLA- matched sister. He was in the third partial remission at the time of bone marrow transplantation. He was conditioned with cyclophosphamide 60 mg/kg/day on two consecutive days, followed by 800 rads total body irradiation. Marrow...
One Case of Neonatal Acute Lymphocytic Leukemia.
Une Hee Choi, Sang Ki Whang, In Soon Lee, In Bok Lee, Eun Cho Yang, Heum Rea Park
Clin Exp Pediatr. 1984;27(11):1103-1107.   Published online November 30, 1984
A 26 days old male with petechiae, ecchymoses and hepatosplenomegaly was admitted to the Department of Pediatrics, at In Cheon Gil Hospital on Jnue, 1983. Peripheral blood smear and bone marrow studies revealed acute lymphocytic leukemia. Autopsy findings revealed that abundant lymphoblastic leukemic cell infiltrated in bone marrow, liver, spleen, kidney and other organs in male newborn infant who died 29 days after birth. And...
Original Article
Clinical Observation of Acute Lymphocytic Leukemia with Mediastinal Mass.
In Sil Lee, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1984;27(4):343-349.   Published online April 30, 1984
Twenty four cases of acute lymphocytic leukemia with mediastinal mass were studied at the Department of Pediatrics, Seoul National University Hospital from September 1965 to August 1983. Analysis were done with regard, to age, sex, chief complaints, organ size (liver, spleen and lymph nodes), initial hemoglobin, white blood cell and platelet count, initial bone marrow findings and lymphoblast surface markers....
Case Report
A Case of Acute Lymphocytic Leukemia with Both Renal Enlargement.
Bok Hee Oh, Young Hoon Soung, Woo Gill Lee, On Koo Cho
Clin Exp Pediatr. 1983;26(11):1149-1153.   Published online November 30, 1983
A Case of acute lymphocytic leukemia with both renal enlargement found l^year old female has been presented. After treatment , acute lymphocytic leukemia with chemotherapeutic agent, the size of both kidneys were decreased and returned to normal shape by ultrasonogram series. A brief review of the literature was made on this subject.
Original Article
The Physical and Hematological Obserbation of Neonatal Jaundice.
sh Park, wj Shin, yh Yu, hs Lee
Clin Exp Pediatr. 1982;25(3):277-282.   Published online March 31, 1982
A clinical study was made on 47 cases of acute lymphocytic leukemias which ad been treated at pediatric department of Keimyung University Hospital during the period of four and a half years from January 1976 through June 1980. 47 cases of acute lymphocytic leukemia occupied 73.4% of all acute childhood leukemia. Acute lymphocytic leukemia tends to have relatively increasing incidence...
Clinical Observations on Childhood Acute Lymphocytic Leukemia.
S H Shin, Y K Kwon, C M Kang
Clin Exp Pediatr. 1982;25(3):269-276.   Published online March 31, 1982
A clinical study was made on 47 cases of acute lymphocytic leukemias which ad been treated at pediatric department of Keimyung University Hospital during the period of four and a half years from January 1976 through June 1980. 47 cases of acute lymphocytic leukemia occupied 73.4% of all acute childhood leukemia. Acute lymphocytic leukemia tends to have relatively increasing incidence...
Testicular Leukemia.
Young Jin Hong, Jung Yeun Choi, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1982;25(1):29-35.   Published online January 31, 1982
Leukemic infiltration of the testes has been relatively rare disease. But increased survival due to advance in the treatment of childhood leukemia has been associated with an increase in incidence of leukemic infiltration of the tests. Six of 66 male children with acute lymphocytic leukemia and 2 of 2 male children with leukemic transformation on non-Hodgkin's lymphoma, who have been...
Clinical Observation on Factors Influencing Survival in Pediatric Acute Lymphocytic Leukemia.
Chang Yee Hong, Jung Yeun Choi, Hyo Seop Ahn
Clin Exp Pediatr. 1982;25(1):8-18.   Published online January 31, 1982
Sixty two properly treated acute lymphocytic leukemia cases who were diagnosed at SNUH, from 1958 to July, 1981 were studied. Among them, 20 cases had survived more than 3 years and 42 cases survived less than 3 years. The 11 cases of 20 are now alive and off theray and the remainder 9 cases were expired after survival for more...
Case Report
A Case of Acute Lymphocytic Leukemia with Both Renal Enlargement.
Choong Kil Chung, Jae Seung Lee, Byung Soo Kim
Clin Exp Pediatr. 1981;24(5):502-504.   Published online May 15, 1981
A case of acute lymphocytic leukemia with both renal enlargement found in a 2 3/12-year-old female has been presented. A brief review of the literatures was made on this subject.