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Original Article

Oncology

Metformin displays in vitro and in vivo antitumor effect against osteosarcoma

Yunmi Ko, Aery Choi, Minyoung Lee, Jun Ah Lee

Clin Exp Pediatr. 2016;59(9):374-380. Published online September 21, 2016

Crossref 11

Purpose

Patients with unresectable, relapsed, or refractory osteosarcoma need a novel therapeutic agent. Metformin is a biguanide derivative used in the treatment of type II diabetes, and is recently gaining attention in cancer research.

Methods

We evaluated the effect of metformin against human osteosarcoma. Four osteosarcoma cell lines (KHOS/NP, HOS, MG-63, U-2 OS) were treated with metformin and cell proliferation was evaluated using...

DOI: https://doi.org/10.3345/kjp.2016.59.9.374

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