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Original Article

Bystander Effect of HSV-TK/GCV Gene Therapy in Murine Neuroblastoma

Eun Jung Shim, Se Ryoung Kim, Eun Hae Park, Hyun Sang Cho, Jae Kook Cha, Hae Ran Lee

Clin Exp Pediatr. 2001;44(11):1249-1253. Published online November 15, 2001

Purpose : To demonstrate the bystander effect in murine neuroblastoma model which transduced with HSV-TK gene in vitro and in vivo. Methods : The LNC/TK vector was transfered in vitro into the neuro-2a cells, murine neuroblastoma cell line. Variable mixed populations of neuro-2a cells consisting of HSV-TK＋ or HSV-TK－ were plated into culture plates and treated with GCV for...

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