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Case Report

A Case of Congenital Chloride Diarrhea in Premature Infant

Sung Kwan Yoon, Eun Young Kim, Kyung Rye Moon, Sang Kee Park

Clin Exp Pediatr. 2003;46(3):308-311. Published online March 15, 2003

Congenital chloride diarrhea is a serious autosomal recessive disease, and defect of intestinal electrolyte absorption that involves, specifically, Cl－/HCO3－ exchange in the distal part of the ileum and colon. The clinical feature is dominated by profuse, watery diarrhea containing high concentrations of chloride(>90 mmol/L) and sodium. The chloride loss results in severe dehydration with a hypochloremic alkalosis. The molecular pathology...

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