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Original Article

Apoptotic Pathway Induced by Dominant Negative ATM Gene in CT-26 Colon Cancer Cells

Jung Chang Lee, Ho Keun Yi, Sun Young Kim, Dae Yeol Lee, Pyoung Han Hwang, Jin Woo Park

Clin Exp Pediatr. 2003;46(7):679-686. Published online July 15, 2003

Purpose : Ataxia telangiectasia mutated(ATM) is involved in DNA damage responses at different cell cycle checkpoints, and signalling pathways associated with regulation of apoptosis in response to ionizing radiation(IR). However, the signaling pathway that underlies IR-induced apoptosis in ATM cells has remained unknown. The purpose of this study was, therefore, to investigate the apoptotic pathway that underlies IR-induced apoptosis in...

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