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Original Article

The Changes of Thyroid Function Tests and TSH Receptor Antibody Levels During Antithyroid Drug Therapy of Graves Disease in Children

Jeong-Ho Kim, Eun-Young Cho, Han-Wook Yoo

Clin Exp Pediatr. 1995;38(10):1404-1410. Published online October 15, 1995

The mainstay of treatment in children with Graves' disease is antithyroid drug therapy. Most commonly used drugs are methimazole(MMI) and propylthiuracil(PTU). These drugs inhibit thyroid hormone synthesis through mechanisms that interfere with the action of thyroid peroxidase. Since antithyroid drugs are unable to inhigit the secretion of thyroid hormone which is already produced, it takes 2 to 3 weeks for...

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