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Cardiology

Changes of Bax, Bcl-2, CCR-2, MCP-1, and TGF-β1 genes in the left ventricle of spontaneously hypertensive rat after losartan treatment

Hyeryon Lee, Kwan Chang Kim, Young Mi Hong

Clin Exp Pediatr. 2019;62(3):95-101. Published online October 24, 2018

Crossref 2

Purpose: Increased apoptosis was recently found in the hypertrophied left ventricle of spontaneously hypertensive rats (SHRs). Although the available evidence suggests that apoptosis can be induced in cardiac cells by various insults including pressure overload, cardiac apoptosis appears to result from an exaggerated local production of angiotensin in adult SHRs. Altered expressions of Bcl associated X (Bax), Bcl-2, chemokine receptor...

DOI: https://doi.org/10.3345/kjp.2018.06856

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