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Original Article

Neuroprotective Effects of Minocycline in Rat Brain Cortical Cell Culture Induced by Hypoxia

Kyung A Ha, Bum Seok Yang, Jin Kyung Kim, Hong Tae Kim, Sung Jin Ha, Jong Won Lee, Hai Lee Chung, Woo Taek Kim

Clin Exp Pediatr. 2003;46(11):1101-1106. Published online November 15, 2003

Purpose : In vivo, minocycline appears to be neuroprotective. Thus, the neuroprotective effects of minocycline were studied in a rat brain cortical cell culture induced by hypoxia. Methods : Cultured cells from the brains of Sprague-Dawley rats were divided into two sets of groups : normoxia groups treated with 5% CO2 and hypoxia groups treated with 1% CO2. After several...

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