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Original Article

Effect of Oxygen Radicals on Cultured Cerebral Neurons of Neonatal Mouse

Yeon-kyun Oh, Seung-taek Park

Clin Exp Pediatr. 1997;40(6):786-793. Published online June 15, 1997

Purpose : In order to elucidate the neurotoxic mechanism of oxygen radicals which are pathological factor of ischemia, we evaluated the oxidant-induced neurotoxicity and the neuroprotective effect of antioxidant on cultured cerebral neurons derived from neonatal mouse. Methods : Neurotoxic effect was investigated after cultured mouse neuronal cells were exposed to oxygen radicals which were generated enzymatically by reaction of xanthine oxidase(XO) and hypoxanthine(HX). And also...

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