Clinical and Experimental Pediatrics

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Original Article

Short term outcomes of topiramate monotherapy as a first-line treatment in newly diagnosed West syndrome

Gyu Min Lee, Kyung Suk Lee, Eun Hye Lee, Sajun Chung

Clin Exp Pediatr. 2011;54(9):380-384. Published online September 30, 2011

Crossref 5

Purpose

To investigate the efficacy of topiramate monotherapy in West syndrome prospectively.

Methods

The study population included 28 patients (15 male and 13 female children aged 2 to 18 months) diagnosed with West syndrome. After a 2-week baseline period for documentation of the frequency of spasms, topiramate was initiated at 2 mg/kg/day. The dose was increased by 2 mg/kg every week to a...

DOI: https://doi.org/10.3345/kjp.2011.54.9.380

A Case of Lissencephaly with West Syndrome.

Byoung Yul Lim, Ji Ho Song, Sa Jun Chung, Chang Il Ahn

Clin Exp Pediatr. 1990;33(10):1413-1417. Published online October 31, 1990

Neuronal migrational disorders of the brain represent abnormalities in the formation of the neocortex caused by faulty migration of the subependimal neuroblasts. Lissencephaly is a rare congenital anomaly representing an arrest of brain development before the third or fourth month of gestaional age. The most common clinical findings were seizure, delayed development, failure to thrive and hydrocephalus. The authors experienced a case of lissencephaly with...

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Clinical and Experimental Pediatrics is an open access journal. All articles are distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/)